Post-transplantation laryngeal actinomycosis

Publication date: Available online 20 December 2018

Source: Auris Nasus Larynx

Author(s): Hirofumi Sei, Jumpei Nouta, Shota Miyaji, Naohito Hato

Abstract

A case of laryngeal actinomycosis occurred after bone marrow transplantation was reported. The patient was a 14-year-old girl who had a history of bone marrow transplantation for the treatment of acute lymphocytic leukemia 4 month before the onset of the disease. She was referred to our hospital complaining persistent sore throat since 2 weeks ago. Fiberscopic observation proved the presence of white tumor-like mass on her right arytenoid of the larynx. As CT image demonstrated that the mass was localized at the arytenoid region with central low-density area surrounded by granulation tissue, we underwent biopsy under local anesthesia. Excision of the mass proved it to be a soft granulation including sulfur granules. Oral administration of amoxicillin 750 mg per day was initiated as a postoperative medication. On day 17, histological study confirmed that the tumor-like mass was Actinomyces granuloma, and therefore amoxicillin administration continued. The medication was effective to subside the disease and the arytenoid lesion healed on day 31. Amoxicillin was further administered until day 70 to prevent recurrence. At 6 month after the biopsy, she was free from the disease.

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