Epidemiology of Nickel Sensitivity: Retrospective Cross-Sectional Analysis of North American Contact Dermatitis Group (NACDG) Data 1994-2014

Detailed analyses of trends in nickel sensitivity in North America are lacking. Clinicians should be aware of a significant increase in nickel sensitivity over time (14.3% to 20.1% from 1994 to 2014) and significant increase in current clinical relevance of reactions over time (44.1% to 51.6% from 1994 to 2014).