Dermal CD207 negative migratory dendritic cells are fully competent to prime protective, skin homing CTL responses

Dendritic Cells (DC) are important inducers and regulators of T cell responses. They are able to activate- and modulate the differentiation of CD4+ and CD8+ T cells. In the skin there are at least five phenotypically distinct DC subpopulations that can be distinguished by differential expression of the cell surface markers CD207, CD103 and CD11b. Previous studies have suggested, that dermal CD11b−CD207+ conventional type 1 DC (cDC1) are indispensable for the priming of a skin homing cytotoxic T lymphocyte (CTL) response.