Parietal Representations of Stimulus Features Are Amplified during Memory Retrieval and Flexibly Aligned with Top-Down Goals

In studies of human episodic memory, the phenomenon of reactivation has traditionally been observed in regions of occipitotemporal cortex (OTC) involved in visual perception. However, reactivation also occurs in lateral parietal cortex (LPC), and recent evidence suggests that stimulus-specific reactivation may be stronger in LPC than in OTC. These observations raise important questions about the nature of memory representations in LPC and their relationship to representations in OTC. Here, we report two fMRI experiments that quantified stimulus feature information (color and object category) within LPC and OTC, separately during perception and memory retrieval, in male and female human subjects. Across both experiments, we observed a clear dissociation between OTC and LPC: while feature information in OTC was relatively stronger during perception than memory, feature information in LPC was relatively stronger during memory than perception. Thus, while OTC and LPC represented common stimulus features in our experiments, they preferentially represented this information during different stages. In LPC, this bias toward mnemonic information co-occurred with stimulus-level reinstatement during memory retrieval. In Experiment 2, we considered whether mnemonic feature information in LPC was flexibly and dynamically shaped by top-down retrieval goals. Indeed, we found that dorsal LPC preferentially represented retrieved feature information that addressed the current goal. In contrast, ventral LPC represented retrieved features independent of the current goal. Collectively, these findings provide insight into the nature and significance of mnemonic representations in LPC and constitute an important bridge between putative mnemonic and control functions of parietal cortex.

SIGNIFICANCE STATEMENT When humans remember an event from the past, patterns of sensory activity that were present during the initial event are thought to be reactivated. Here, we investigated the role of lateral parietal cortex (LPC), a high-level region of association cortex, in representing prior visual experiences. We find that LPC contained stronger information about stimulus features during memory retrieval than during perception. We also found that current task goals influenced the strength of stimulus feature information in LPC during memory. These findings suggest that, in addition to early sensory areas, high-level areas of cortex, such as LPC, represent visual information during memory retrieval, and that these areas may play a special role in flexibly aligning memories with current goals.