The hyperproliferative human epidermal keratinocytes HaCaT are often used in experimental studies of psoriasis. Recently, we reported that Th1 cytokines TNF, IFN-γ and IL17 exhibited an antiproliferative effect on HaCaT cells. The aim of this paper was to explore how knocking matrix metalloproteinase 1 (MMP1) down in epidermal keratinocytes affected their proliferation, migration and differentiation and be beneficial for psoriasis. MMP1-deficient and control cells were generated by lentiviral transduction.
Τετάρτη 19 Σεπτεμβρίου 2018
LB1537 Matrix metalloproteinase 1 deficiency in epidermal keratinocytes makes them susceptible to IFN-γ and impairs their migration
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Small molecule inhibitor of the Wnt pathway (SM04755) as a potential topical treatment for psoriasisBackground: Psoriasis (PSO) is an autoimmune disease causing patches of thick, inflamed, scaly skin due to excessive proliferation of skin c...
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Photochemistry and Photobiology, Volume 0, Issue ja , -Not available-.
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