Transdermal effectiveness of a lipid-based antimicrobial emulsion

A proprietary lipid-based emulsion (ML:8) with established antimicrobial efficacy was investigated. To model a clinical situation in which bacteria have penetrated the integumentary barrier, a reference strain of Staphylococcus aureus (NCTC 8255-4) was inoculated into the subdermal compartment of isolated sheets of pig skin mounted between two chamber-halves to permit separate access to surface and to subdermal compartments. The objective was to evaluate transdermal efficacy of a range of concentrations of ML:8 through porcine skin in vitro.