Rate of regional nodal metastases of cutaneous squamous cell carcinoma in the immunosuppressed patient: An update

Background: The immunosuppressed patient has both an increased incidence of cutaneous squamous cell carcinoma (SCC) and a worse prognosis due to the propensity for metastatic spread. The single most important prognostic indicator for mortality in patients with SCC is the presence or development of regional lymph node metastasis. Previous studies have sought to determine the rate of regional lymph node metastases in solid organ transplant recipients (SOTRs). However, reported rates appear surprisingly low and are limited to only SOTRs.