From relative to absolute treatment outcomes—Correlation of PASI 90 and PASI ≤2 in three clinical trials with secukinumab

Introduction: Relative improvement of psoriasis area and severity index (PASI) during treatment compared with baseline PASI is the current standard definition of response in trials and practice. A ≥75% improvement in PASI (PASI 75) is the current treatment goal in international guidelines. With the advent of more effective biologic treatments, an improvement by ≥90% (PASI 90) is under consideration as a new treatment goal. As an alternative for long-term management, baseline-independent absolute PASI treatment goals are being discussed.