Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma

It is well known that melanin is synthesized from tyrosine, one of the essential amino acids, through the catalytic action of tyrosinase and plays a pivotal role in the pigmentation of living organisms. In the skin, melanin has been shown to protect skin cells from severe sun damage, especially from ultraviolet exposure [1]. Many cosmetic companies have developed a large number of lightening/whitening cosmetics for people who psychologically suffer from their skin color, age spots and/or uneven skin pigmentation.