Dermatofibrosarcoma Protuberans: A Retrospective Study of Clinicopathological Features and Related Akt/mTOR, STAT3, ERK, Cyclin D1, and PD-L1 Expression

In dermatofibrosarcoma protuberans, fibrosarcomatous subtype and inadequate surgical margin portend aggressive behavior. Complex factors of frequent local recurrence, larger tumor size, deeper invasion, fibrosarcomatous or myxoid subtype, and cyclin D1 high expression appear to predict worse outcome. Patients with dermatofibrosarcoma protuberans exhibiting any risk factor should be followed up comprehensively.