Anti-Pruritic and Anti-Inflammatory Effects of Oxymatrine in a Mouse Model of Allergic Contact Dermatitis

Allergic contact dermatitis (ACD) [1] is a highly prevalent inflammatory disease of the skin, which is mediated by hapten-specific T-cells and caused by repeated exposure of the skin to the same hapten [2]. ACD usually presents with inflammatory responses including erythema, swelling and immune imbalances. Patients with ACD often also exhibit refractory pruritus. Pruritus is an uncomfortable sensation which can trigger the urge to scratch [3]. Refractory pruritus, also called chronic pruritus, occurs repeatedly and negatively affects attention and sleep quality.