Reversal of the hair loss phenotype by modulating the estradiol-ANGPT2 axis in the mouse model of female pattern hair loss

Female pattern hair loss (FPHL) is characterized by diffuse hair thinning mainly at the vertex and upper parietal scalp [1]. Unlike male androgenetic alopecia, the frontal hairline is infrequently affected in FPHL. FPHL is not a life-threatening disease; however, there is a great demand for treatment, as this condition reduces body image and causes psychologically stress in affected individuals [2]. However, available treatment options for FPHL are very limited [3]. Male pattern hair loss can be mainly explained by androgen-dependent acceleration of the hair cycle with resultant hair follicle miniaturization, while FPHL is considered to be heterogeneous, and the pathophysiology of FPHL is more complicated than that of male pattern hair loss.