Introduction: Autoinflammatory Syndromes Special Issue—hidden mysteries in the corners of autoinflammation

This is the 18th year of ongoing research in 'autoinflammation'. Since the genetic and pathogenic characterization of the first autoinflammatory diseases—familial Mediterranean fever (FMF) and TNF-receptor associated periodic syndrome (TRAPS)—further genetic and clinical discoveries have advanced hand in hand with basic discoveries of innate-immune sensors and pathways that link danger-sensing to the production and release of key pro-inflammatory cytokines (1).