The UVA-induced long non-coding RNA GS1-600G8.5 regulates the expression of IL-8

Exposure of the skin to ultraviolet radiation (UVR) has many detrimental effects, including sunburning/inflammation, photocarcinogenesis, and photoaging. Longwave ultraviolet radiation (UVA) has long been considered less damaging than shortwave ultraviolet radiation (UVB), but has since been recognized to be a complete carcinogen itself [1], to be a particular cause of photoaging, and to elicit a number of inflammatory photodermatoses. Cells are equipped to counteract the damaging effects of UVR and respond to UVR by altering the expression of thousands of genes [2].