Is flucloxacillin monotherapy sufficient for the treatment of skin and soft tissues infections in plastic surgery?

Skin and soft tissue infections (SSTIs) are commonly managed by plastic surgeons throughout the UK particularly in upper limb and in burns. With an ageing population, and an increasing number of immunocompromised and critically ill patients, the incidence of SSTIs is rising. An important cause of morbidity and mortality, correct recognition and management is vital. Staphylococcus aureus and beta-hemolytic streptococci (Group A, C & G predominantly) are the most common causative pathogens of SSTIs and accordingly prompt, and appropriate, antimicrobial therapy forms the mainstay of treatment along with strict elevation and early surgical debridement (if indicated).