Gasdermin C is Induced by Ultraviolet Light and Contributes to MMP-1 Expression via Activation of ERK and JNK Pathways

Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases that are able to degrade extracellular matrix proteins [1–3]. MMP family members can be categorized into four different subfamilies: collagenases, stromelysins, gelatinases, and membrane-type MMPs [3–5]. MMPs play important roles in various physiological and pathological processes including developmental morphogenesis, tissue repair, skin aging, and tumor invasion. Expressions of some MMPs are regulated by diverse extracellular stimuli including UV, proinflammatory cytokines, and growth factors [4,6–9].