ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with AS susceptibility in Chinese Han

SUMMARY

Previous studies show that ERAP1/ERAP2 and RUNX3 gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. Purpose of this study was to determine whether 11 candidate SNPs in ERAP1/ERAP2 and 6 in RUNX3 genes confer susceptibility to AS with or without AAU (AS⁺AAU⁺ or AS⁺AAU^-) in Chinese Han. Therefore, a case-control association study was performed in 882 AS⁺AAU^-, 884 AS⁺AAU⁺ and 1727 healthy controls. Genotyping was performed using iPLEXGold genotyping assay. A meta-analysis was performed to assess the association of polymorphisms of ERAP1 with AS susceptibility in Asian populations. No association was found between SNPs of ERAP1/ERAP2/RUNX3 and susceptibility of AS with or without AAU. A case-control study between patients with HLA-B27 positive and healthy controls also failed to demonstrate an association of the tested SNPs with AS with or without AAU. Moreover, a meta-analysis showed that there was no association of rs30187, rs27037, rs27980, rs27434 and rs27582 in ERAP1 with AS in Chinese Han. Taken together, 17 SNPs in ERAP1/ERAP2 and RUNX3 genes did not confer disease susceptibility to AS in Chinese Han. This article is protected by copyright. All rights reserved.