<div id="tabs" class="ui-tabs-nav"> <ul> <li>Autophagy Receptor</li> <li>LC3 Isoforms</li> <li>Nuclear Regulation</li> </ul> <div class="tabs-container"> <div class="tabs-tab"> <table cellpadding="4" cellspacing="4"> <tr> <td> <h2>Selective Autophagy Receptors</h2> <p> <b>Ubiquitin-Dependent Autophagy</b>: In ubiquitin-dependent autophagy, selective autophagy receptor proteins interact with their specific cargo via their ubiquitin binding domain (UBD). This selective autophagy pathway is believed to cooperate with the ubiquitin-proteasome system in the targeting and elimination of protein aggregates. Considerable overlap exists in the selectivity of the receptors. </p> <p align="center"><img src="http://ift.tt/2megPZZ" alt="Selective Autophagy Receptors"></p> <p> <b>Ubiquitin-Independent Autophagy</b>: Receptors involved in this pathway recognize a variety of molecules as cargo including proteins, sugars and lipids. This type of selective autophagy was initially identified in yeast, but more recently specific pathways have been recognized in eukaryotes. </p> </td> </tr> <tr> <td> <table width="100%"> <tr bgcolor="#005F9E"> <td width="30%"> <span style="color: #FFFFFF; font-weight: bold;">Cytosolic Cargo</span> </td> <td width="30%"> <span style="color: #FFFFFF; font-weight: bold;">Ubiquitin-Dependent</span> </td> <td width="40%"> <span style="color: #FFFFFF; font-weight: bold;">Ubiquitin-Independent</span> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <a href="/research-areas/cellular-markers/mitochondrial-markers.html">Mitochondria</a> </td> <td> <a href="/common-name/optineurin">OPTN</a>, <a href="/common-name/ndp52">NDP52</a>, <a href="/common-name/tax1bp1">TAX1BP1</a>, <a href="/common-name/p62-sqstm1">p62</a> </td> <td> <a href="/common-name/bnip3l">NIX/BNIP3</a>, <a href="/common-name/fundc1">FUNDC1</a>, ATG32 </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> Protein Aggregates </td> <td> p62, <a href="/nbr1">NBR1</a>, OPTN, <a href="/common-name/tollip">TOLLIP</a> </td> <td> OPTN </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <a href="/research-areas/cellular-markers/peroxisome-markers.html">Peroxisomes</a> </td> <td> NBR1, p62 </td> <td> ATG30, ATG36 </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> Bacteria </td> <td> p62, OPTN, NDP52, TAX1BP1 </td> <td> Galectin-8/NDP52 </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> RNA granules </td> <td> NDP52, p62 </td> <td> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> Proteasome </td> <td> <a href="/common-name/s5a-angiocidin">RPN10</a> </td> <td> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <a href="/research-areas/cellular-markers/er-markers.html">Endoplasmic Reticulum</a> </td> <td> </td> <td> <a href="/common-name/fam134b">FAM134B</a> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> Viruses </td> <td> </td> <td> <a href="/common-name/trim5">TRIM5α</a>, <a href="/common-name/smurf1">SMURF1</a>, p62 </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <a href="/research-areas/cellular-markers/nuclear-envelope-markers.html">Nuclear Envelope</a> </td> <td> </td> <td> ATG39 </td> </tr> </table> <br/> <br/> <p align="center"><a href="/research-areas/autophagy/macroautophagy" class="link_button">Explore Detection Methods</a></p> <br/><br/> </td> </tr> </table> </div> <div class="tabs-tab"> <h2>LC3 and GABARAP Family Members</h2> <p>In mammals seven LC3 family members have been identified that belong to two main sub-families, LC3 and GABARAP. Different LC3 proteins may play specific roles in selective autophagy mechanisms.</p> <table width="100%" cellpadding="4" cellspacing="4"> <tr bgcolor="#005F9E"> <td width="50%"> <span style="color: #FFFFFF; font-weight: bold;">Sub-Family</span> </td> <td width="50%"> <span style="color: #FFFFFF; font-weight: bold;">Isoforms</span> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> LC3 </td> <td> <a href="/common-name/lc3a">MAP1LC3A</a>, <a href="/common-name/lc3b">MAP1LC3B</a>, MAP1LC3B2, <a href="/common-name/lc3c">MAP1LC3C</a> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> GABARAP </td> <td> <a href="/common-name/gabarap">GABARAP</a>, <a href="/common-name/gabarapl1">GABARAPL1</a>, <a href="/common-name/gate-16-gabarapl2">GABARAPL2</a>, GABARAPL3* </td> </tr> </table> <p>Isoforms share 29-94% sequence identity. *Only subfamily member not involved in formation of autophagosomes. </p> <br/> <p align="center"><a href="/support/autophagy/LC3/top-cited" class="link_button">Explore Top Cited LC3B Antibody</a></p> <br/> </div> <div class="tabs-tab"> <h2>Transcriptional Regulation</h2> <p> Various transcriptional regulatory axes have been identified to modulate autophagy. Translocation of transcription factors between the cytoplasm and the nuclei determines their function as modulators of autophagy. Each axis regulates autophagy via unique mechanisms. </p> <br/> <ol style="list-style: none;"> <li><a href="/common-name/tfeb">TFEB</a>/<a href="/common-name/zkscan3">ZKSCAN3</a> <b>axis</b>: Both transcription factors bind to overlapping promoter regions and regulate the expression of similar ATG genes. </li> <br/> <li><b>FOXO axis</b>: <a href="/common-name/foxo1-fkhr">FOXO1</a> is required for the transcriptional activation of autophagy genes by <a href="/common-name/foxo3">FOXO3</a>. </li> <br/> <li><a href="/common-name/e2f-1">E2F1</a> <b>and</b> <a href="/common-name/rela-nfkb-p65">NF-kB</a> <b>axis</b>: Inhibitory crosstalk between these two transcription factors is involved in the regulation of autophagy. </li> </ol> <br/> <p align="center"><img src="http://ift.tt/2qGAMxd" alt="Transcriptional Regulation"></p> <br/> <p> <b>Epigenetic Control:</b><br/> Research in autophagy has predominantly centered on the cytoplasmic mechanisms that regulate this process. However, recent findings have identified intricate regulatory pathways involving DNA and histone modifying enzymes that dynamically fine-tune the process of autophagy. </p> <br/> <table cellpadding="4" cellspacing="4"> <tr bgcolor="#005F9E"> <td width="30%"> <span style="color: #FFFFFF; font-weight: bold;">Enzymatic Mechanism</span> </td> <td width="40%"> <span style="color: #FFFFFF; font-weight: bold;">Autophagy Related Genes Modulated</span> </td> <td width="30%"> <span style="color: #FFFFFF; font-weight: bold;">Associated Autophagic State</span> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td valign="top"> <a href="/common-name/dnmt2">DNMT2</a> Hypermethylation </td> <td valign="top"> ATG5 and LC3 downregulated </td> <td valign="top"> Reduced autophagy </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td valign="top"> ESA1/<a href="/common-name/histone-deacetylase-2-hdac2">RPD3</a> axis Acetylation/Deacetylation of H4 </td> <td valign="top"> Ribosomal Protein upregulated/ downregulated LC3 expression regulation </td> <td valign="top"> Reduced/Increased autophagy </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td valign="top"> <a href="/common-name/g9a-ehmt2">G9A</a> Methylation of H3K9 </td> <td valign="top"> LC3, WIPI1 and DOR downregulated </td> <td valign="top"> Reduced autophagy </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td valign="top"> <a href="/myst1">hMOF</a>/<a href="/common-name/sirtuin-1-sirt1">SIRT1</a> axis Acetylation/Deacetylation of H4K16 </td> <td valign="top"> Autophagy related genes induced/ inhibited </td> <td valign="top"> Balance between cell death and survival </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td valign="top"> <a href="/common-name/usp44">USP44</a> deubiquitination of H2B </td> <td valign="top"> Downregulated genes: regulation of NF-κB and biosynthetic process Upregulated genes: innate immunity and polyubiquitination </td> <td valign="top"> Increased autophagy </td> </tr> </table> <br/><br/> <p align="center"> <a href="/research-areas/epigenetics" class="link_button">Explore Epigenetics Research Area</a> </p> </div> </div> </div>
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