To the Editor—In their recent article, Lopez et al report the identification of specific polysaccharide antibody deficiencies (SPADs) in adults presenting with invasive infection caused by encapsulated bacteria [1]. The identification of SPAD is important as it may permit intervention with strategies to mitigate the risk of subsequent infection, for example, protein-conjugate vaccination, antibiotic prophylaxis, and immunoglobulin replacement. Not all patients, however, with SPAD will require intervention. Up to 11% of healthy individuals meet the immunological criteria for SPAD [2]. More importantly, the identification of an immunological abnormality, which may be incidental to a patient's infection susceptibility, has the potential to distract from consideration of other causes of infection susceptibility. To illustrate this, we present a case of adult-onset, recurrent bacterial meningitis, in which identification of an immunoglobulin G2 (IgG2) subclass deficiency, with associated SPAD, was incidental to his infection susceptibility.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com
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