Primary cutaneous secretory carcinoma: a previously overlooked low grade sweat-gland carcinoma

Abstract

Twelve cases of primary cutaneous secretory carcinoma (PCSC) have been published; nine of them showed the ETV6-NTRK3 translocation and an additional case had a heterozygous deletion of ETV6 in 25% of cells (Table 1).^1-7 These cutaneous tumors are related to secretory breast carcinoma (SBC) and mammary analogue secretory carcinoma (MASC) from the salivary glands, with all sharing a balanced chromosomal translocation of t(12;15)(p13;q25) that leads to ETV6-NTRK3 gene fusion.