Subclinical Sensitization with Diphenylcyclopropenone is Sufficient for the Treatment of Alopecia Areata: Retrospective Analysis of 159 Cases

Conventional diphenylcyclopropenone contact immunotherapy has been used in the treatment of extensive alopecia areata, but can be associated with severe adverse effects (AEs).Even without an eczematous reaction after sensitization, sufficient therapeutic responses were achieved without severe AEs.Sensitization to induce an eczematous reaction may not be required for successful contact immunotherapy.