Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-κB pathways

Psoriasis is a common, immune-mediated, chronic inflammatory skin disease of man. The prevalence ranges from 0% to 8.5%. The occurrence of psoriasis varies according to age and geographic region [1–3]. Psoriasis is characterized by hyperproliferative keratinocytes, parakeratosis, hyperkeratosis, and massive infiltration of inflammatory leukocytes into the dermis and epidermis. The disease severely affects quality of life. The typical histological traits encompass hyperkeratosis of the epidermis, acanthosis, elongation of dermal capillary vessels, and infiltration of inflammatory leukocytes into the dermis and epidermis, which are clinically reflected by erythema, scaling, and thickening.