Commentary on: Effect of Use of Platelet-Rich Plasma (PRP) in Skin With Intrinsic Aging Process

Platelets contain and release growth factors from α-granules during platelet activation as part of a complex and important role of wound healing. The platelet's effects on wound healing with early clot formation and release of mitogenic and chemotactic growth factors have been well established.^1-4 A few of the growth factors that are important regulators of cellular interaction, cell-matrix interaction and angiogenesis include; platelet-derived growth factor (PDGF), endothelial growth factor (EGF), insulin growth factor (IGF), and transforming growth factor beta (TGF-B).⁵ An early attempt to utilize regenerative properties of platelet derived growth factors in oral bone grafts was described by Marx.⁶ Since that time, the attempts to utilize platelet growth factors in regenerative medicine have been applied across disciplines.^7-10