Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes, fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode

Cold atmospheric plasma (CAP) devices are currently being developed for a variety of medical applications and have already shown efficacy for the treatment of chronic and acute wounds in patients accelerating wound healing by activation of wound healing relevant growth factors and cytokines and by killing bacteria. CAP has also revealed antitumoral effects in vitro by inducing malignant cell apoptosis [1–3].