Three-dimensional poly lactic-co-glycolic acid scaffold containing autologous platelet-rich plasma supports keloid fibroblast growth and contributes to keloid formation in a nude mouse model

Keloid formation is an excessive response to dermal injury. The pathology develops when collagen fibers repair the wound surface with an overgrowth of fibrous connective tissues[1]. The response manifests as lumpish scars that are higher than the surrounding normal skin, and that continuously grow beyond the boundaries of the original wound[1–3]. These lesions are usually accompanied by red skin pigmentation, itchiness, and pain, and skin movement is affected. Keloids may occur following any type of skin injury that can lead to scarring (acne, burns, chickenpox, ear piercing, scratches, surgical cuts, and vaccination sites, et al.) [1–3].