Pathogenetic insights from quantification of the cerebriform connective tissue nevus in Proteus syndrome

Plantar cerebriform connective tissue nevus (CCTN) size increases in children with Proteus syndrome, but not in adults.The presence and growth of a plantar CCTN are affected by age of the patient and extent of the precursor lesion.Knowledge of CCTN growth patterns may be useful for predicting the rate of expansion and eventual extent of sole involvement.