Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes

Normal human skin color is the result of the balance between melanin synthesis and melanin degradation [1]. When microenvironment changes, skin depigmentation or hyperpigmentation eventually occurs. It is commonly accepted that hyperpigmentation is mainly caused by two mechanisms: the overactivity and increased numbers of normal melanocytes or the increased production and decreased destruction of melanosomes. Melanocytes, which contain melanosomes, a distinctive lysosome-related organelle, are in charge of melanin biosynthesis.