06:29
Future Oncology, Ahead of Print. http://ift.tt/2ygUoYY
06:29
Future Oncology, Ahead of Print. http://ift.tt/2wRak2B
06:29
Future Oncology, Ahead of Print. http://ift.tt/2ygUnnS
06:29
Future Oncology, Ahead of Print. http://ift.tt/2wRFHKn
06:29
Future Oncology, Ahead of Print. http://ift.tt/2ygUjo8
06:23
The π-accepting property of alkene-like phosphaethenes (-P=C<) has been attractive to develop...
06:23
Abstract Microwave radiometry is a passive technique used to measure in-depth...
06:23
Abstract Due to increasing global demand for crop production and energy use, more and more reactive nitrogen (Nr) has been generated and emitted to the environment. As a result, global atmospheric nitrogen (N) deposition has tripled since the industrial revolution and the ecological environment and...
06:13
Interactions of the presynaptic proteins, neuronal pentraxin 2 (NPTX2) and neurexin 2α (NRXN2α), with their respective postsynaptic functional partners, GluA4-containing glutamate (AMPA4) receptor and neuroligin 1 (NLGN1), enhance excitatory synaptic activity in some areas of the hippocampus and cerebral...
06:13
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a promising strategy for the management of fibrotic disorders,...
06:13
The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and is a crucial pathway for growth of the human bacterial pathogen Enterococcus faecalis. The final enzyme in this pathway, mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diphosphate...
06:09
Pharmacogenomics, Ahead of Print. http://ift.tt/2kJK7S6
06:03
Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase
Altered sphingolipid metabolism is associated with increased inflammation; however, the impact of inflammatory mediators, including neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. Using a well-characterized mouse model of NE oropharyngeal aspiration, we investigated a potential...
06:03
Maintenance of normal epithelial ion and water transport in the lungs includes providing a thin layer of surface liquid that coats the conducting airways. This airway surface liquid is critical for normal lung function in a number of ways, but perhaps most importantly, is required for normal mucociliary...
06:03
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of morbidity and death and imposes major socioeconomic burdens globally. It is a progressive and disabling condition that severely impairs breathing and lung function. There is a lack of effective treatments for COPD, which is a...
05:58
Abstract Myocardial revascularization surgery (CABG) is the most appropriate treatment for coronary artery disease. Currently, the great challenge is to reduce postoperative complications, such as wound infections, dehiscence, pain, and patients' quality of life. The saphenectomy is the target of complications...
05:58
Abstract This study aimed to compare choroidal thickness between subjects with ocular hypertension (OHT) and normal individuals and explore factors affecting choroidal thickness. This study included 60 untreated newly diagnosed OHT eyes and 60 normal eyes. Choroidal thickness obtained from Cirrus HD-OCT...
05:55
Abstract Introduction Dome division or vertical dome division (VDD) is a tip plasty technique that is effective when applied appropriately to suitable patients. For 15 years, we have used VDD and made modifications as needed. In classical VDD, the dome area is cut and left to heal, but experience shows...
05:48
J & B Sausage Company, Inc., doing business as J Bar B Foods, a Waelder, Texas establishment, is recalling approximately 12,816 pounds of fully cooked shredded beef products that may be contaminated with extraneous materials, specifically plastic. from Medicine via paythelady.61 on Inoreader http://ift.tt/2hEoygT
05:46
Xianle Shi, Zixi Yin, Bin Ling, Lingling Wang, Chang Liu, Xianhui Ruan, Weiyu Zhang, and Lingyi Chen from A1 via xlomafota.13 on Inoreader http://ift.tt/2zlUbE2 via IFTTT
05:43
Abstract Among the African American community, there exist many health disparities which warrant greater examination through the practice of social work. The aim of the present research was to explore the impact of religiosity on substance abuse and obesity among African American populations by employing...
05:38
Greencore, USA, LLC is voluntarily recalling egg salad sandwiches, ham salad sandwiches, and seafood stuffing as listed below. The products are being recalled because Listeria monocytogenes was found in environmental sampling conducted by FDA. from Medicine via paythelady.61 on Inoreader http://ift.tt/2z45O1d
05:36
AbstractThe absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with the human Usher mutation,Ush1c c.216G>A,...
05:30
Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma (MM) cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction. Experimental design: We evaluated the effect of daratumumab...
05:30
Purpose: Poorly-differentiated thyroid cancer and anaplastic thyroid cancer (ATC) are rare yet lethal malignancies with limited treatment options. Many malignant tumors including papillary thyroid cancer (PTC) and ATC are associated with increased expression of ICAM-1, providing a rationale for utilizing...
05:20
Coronary microvascular function and blood flow responses during acute exercise are impaired in the aged heart, but can be restored by exercise training. Coronary microvascular resistance is directly dependent on vascular smooth muscle function in coronary resistance arterioles; therefore, we hypothesized...
05:20
N/A from # & – All via ola Kala on Inoreader http://ift.tt/2gAaNQI
05:20
Clinical assessment of right ventricular (RV) contractility in diseases such as pulmonary arterial hypertension (PAH) has been hindered by the lack of a robust methodology. Here, a novel clinically-viable single-beat method was developed to assess end-systolic elastance (Ees), a measure of RV contractility....
05:20
The human arterial vascular tree can be described by multi-compartment models using electrical components. Being first introduced in the 1960s by Noordergraaf and Westerhof these hardware-based approaches required several simplifications. We were able to remove the restrictions using modern software...
05:20
The reason for increased sleep disordered breathing with predominance of central apneas in the elderly is unknown. We hypothesized that the propensity to central apneas is increased in older adults, manifested by a reduced carbon-dioxide (CO2) reserve in older compared to young adults during non-REM...
05:20
N/A from # & – All via ola Kala on Inoreader http://ift.tt/2i6tsan
05:14
The human arterial vascular tree can be described by multi-compartment models using electrical components. Being first introduced in the 1960s by Noordergraaf and Westerhof these hardware-based approaches required several simplifications. We were able to remove the restrictions using modern software...
05:07
Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing...
05:07
Background Severe hypophosphataemia in the intensive care unit (ICU) setting has been widely associated with adverse clinical outcomes across multiple organ systems, as well as increased mortality. However, the clinical significance of mild or moderate hypophosphataemia remains uncertain. This can lead...
05:01
Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity in response remains a major challenge in MM. Cluster of differentiation 38 (CD38) is a type II transmembrane glycoprotein over-expressed in myeloma cells...
05:01
The purpose of this article is to reconsider the manner in which the U.S. Food and Drug Administration (FDA) reviews diagnostic radiopharmaceuticals. Mass characteristics of several common non-radioactive drugs and a number of diagnostic radiopharmaceuticals are considered. A history of the regulation...
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