Incidence of spontaneous intracranial hypotension in a community. Beverly Hills, California, 2006-2020

xlomafota13 shared this article with you from Inoreader Incidence of spontaneous intracranial hypotension in a community. Beverly Hills, California, 2006-2020 Via leak of cerebrospinal fluid Cephalalgia. 2021 Sep 23:3331024211048510. doi: 10.1177/03331024211048510. Online ahead of print. ABSTRACT BACKGROUND: Spontaneous intracranial hypotension is diagnosed with an increasing frequency, but epidemiologic data are scarce. The aim of this study was to determine the incidence rate of spontaneous intracranial hypotension in a defined population. METHODS: Using a prospectively maintained registry, all patients with spontaneous intracranial hypotension residing in Beverly Hills, California, evaluated at our Medical Center between 2006 and 2020 were identified in this population-based incidence study. Our Medical Center is a quaternary referral center for spontaneous intracranial hypotension and is located within 1.5 miles from downtown Beverly Hills. RESULTS: A total of 19 patients with spontaneous intracranial hypotension were identified. There were 12 women and seven men with a mean age of 54.5 years (range, 28 to 88 year s). The average annual incidence rate for all ages was 3.7 per 100,000 population (95% confidence interval [CI]: 2.0 to 5.3), 4.3 per 100,000 for women (95% CI, 1.9 to 6.7) and 2.9 per 100,000 population for men (95% CI, 0.8 to 5.1). CONCLUSION: This study, for the first time, provides incidence rates for spontaneous intracranial hypotension in a defined population. PMID:34553617 | DOI:10.1177/03331024211048510 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Does Radioactive Iodine Therapy for Hyperthyroidism Cause Cancer?

xlomafota13 shared this article with you from Inoreader Does Radioactive Iodine Therapy for Hyperthyroidism Cause Cancer? Via radioactive iodine J Clin Endocrinol Metab. 2021 Sep 23:dgab700. doi: 10.1210/clinem/dgab700. Online ahead of print. ABSTRACT Radioactive iodine has been considered a safe and effective therapeutic option for hyperthyroidism secondary to Graves' disease and autonomously functioning thyroid nodules since the mid-20th century. The question of whether I-131 at the doses used for hyperthyroidism might increase the risk of cancer has been investigated in a number of observational cohort studies over the y ears, with the preponderance of evidence being reassuring as to its safety. In particular, the 1998 Cooperative Thyrotoxicosis Therapy Follow-up Study (CTTFUS) has been widely cited as compelling evidence that I-131 is safe in hyperthyroidism therapy with respect to carcinogenesis. However, in 2019, a study by Kitahara and colleagues re-analyzed the CTTFUS cohort, extending the follow-up time and applying a novel dosimetric model for estimating tissue absorbed doses of radiation. This new analysis concluded that radioactive iodine was associated with an increased risk for mortality from overall cancer, breast cancer, and non-breast solid cancers. Reaction to this study was vociferous and particularly negative in the nuclear medicine literature. This mini-review was inspired by the 2019 CTTFUS controversy, and is intended to provide the necessary context for clinicians to provide nuanced advice to their patients on the subject. To that end, the pre-2019 literature is surveyed, the 20 19 CTTFUS study and a 2020 follow-up are discussed, and lessons from the literature and critical commentaries are considered. PMID:34555150 | DOI:10.1210/clinem/dgab700 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Anterior Glottic Web Secondary to Bioenzyme Toxicity

xlomafota13 shared this article with you from Inoreader Anterior Glottic Web Secondary to Bioenzyme Toxicity Via ear nose throat Ear Nose Throat J. 2021 Sep 23:1455613211044774. doi: 10.1177/01455613211044774. Online ahead of print. NO ABSTRACT PMID:34553632 | DOI:10.1177/01455613211044774 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A contemporary narrative review to guide molecular epidemiology of oral submucous fibrosis

xlomafota13 shared this article with you from Inoreader A contemporary narrative review to guide molecular epidemiology of oral submucous fibrosis Via International Journal of Molecular Epidemiology and Genetics Int J Mol Epidemiol Genet. 2021 Aug 15;12(4):61-70. eCollection 2021. ABSTRACT Oral submucous Fibrosis (OSMF) is a chronic disease that mainly affects the upper part of the aerodigestive tract. Areca nut and betel quid chewing has been established as the most significant causative factor for this condition. While OSMF is a predominantly Asian disease, the migrant populations from the region have taken the disease across the globe. Additionally, areca nut is now easily accessible in flavors and aggressively marketed. Many research activities have been undertaken for decades to understand the etiopathogenesis and risk factors of OSMF. Although OSMF is a slowly progressing disease, it has the potential to transform to an oral malignancy. This article is an attempt to review the literature and provide an update on its prevalence, etiopthogenesis and its diagnosis. We also highlight certain clinical, histopathological and molecular features that aid in the diagnosis and prognostication of OSMF, highlighting the importance of identifying the possibly high risk OSMF that is prone to malignant transformation. Using this information, future directions can be developed to include treatmentof OSMF through a dynamic gene-specific approach. PMID:34552689 | PMC:PMC8449189 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Expression and Regulation of Na+-K+-ATPase in Nasal Epithelial Cells of Chronic Rhinosinusitis with Nasal Polyps

xlomafota13 shared this article with you from Inoreader The Expression and Regulation of Na<sup>+</sup>-K<sup>+</sup>-ATPase in Nasal Epithelial Cells of Chronic Rhinosinusitis with Nasal Polyps Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Objective: Na+-K+-ATPase (NKA) is essential in maintaining cell permeability, reserving potential energy, and preventing cellular edema. Nevertheless, how NKA expression is altered and regulated in chronic rhinosinusitis with nasal polyps (CRSwNPs) remain uncertain. Therefore, the present study aimed to explore the expression and regulation of NKA in CRSwNP. Methods: NKA immunolabeling was assessed by the immunohistochemistry method, NKA prote in levels were detected with the Western blotting method, and mRNA levels of NKA and aquaporin-5 (AQP5) were assayed by real-time PCR in nasal tissues from CRSwNP and control subjects. The co-localization of NKA with inflammatory cells was evaluated by immunofluorescence staining. In addition, human nasal epithelial cells (HNECs) were cultured and stimulated using various stimulators to evaluate the regulation of NKA. Results: We found significantly decreased NKA positive cells, NKA protein levels, and mRNA levels of NKA and AQP5 in nasal tissues from CRSwNP patients compared to control subjects, especially in eosinophilic CRSwNP. Furthermore, NKA mRNA levels in HNECs were downregulated by staphylococcal enterotoxin B (SEB), lipopolysaccharides (LPSs), inflammatory cytokine (IFN)-γ, IL-4, IL-13, and IL-1β. Conclusion: NKA and AQP5 expressions were decreased in CRSwNP. NKA in HNECs could be suppressed by SEB, LPS, IFN-γ, IL-4, IL-13, and IL-1β. Impairm ent of NKA may contribute to the genesis and development of CRSwNP via inducing AQP5 downregulation and edema. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Complications Associated With Nasopharyngeal COVID-19 Testing: An Analysis of the MAUDE Database and Literature Review

xlomafota13 shared this article with you from Inoreader Complications Associated With Nasopharyngeal COVID-19 Testing: An Analysis of the MAUDE Database and Literature Review Via leak of cerebrospinal fluid Am J Rhinol Allergy. 2021 Sep 21:19458924211046725. doi: 10.1177/19458924211046725. Online ahead of print. ABSTRACT BACKGROUND: Nasopharyngeal swab testing, which has greatly increased in utilization due to the COVID-19 pandemic, is generally safe and well-tolerated, although it may be rarely associated with adverse events. METHODS: Publicly reported adverse events associated with nasopharyngeal COVID-19 testing within the Manufacturer and User Facility Device Experience (MAUDE) database and the published literature were queried. RESULTS: A total of 129 adverse events were reported, including 66 from the MAUDE database and 63 from literature review. The most common complications were swab fracture resulting in retained foreign body (47%), followed by epistaxis (17%), and headache (11%). Seven (12%) of the reported retained foreign body cases required removal under general anesthesia, while 1 (5%) of the epistaxis cases required su rgical intervention. The most serious adverse event was meningitis following cerebrospinal fluid leak. CONCLUSIONS: Patients and healthcare providers should be aware of the potential risks associated with testing, with attention to ensuring proper technique, and be prepared to recognize and manage adverse events. PMID:34547903 | DOI:10.1177/19458924211046725 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Central nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case report

xlomafota13 shared this article with you from Inoreader Central nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case report Via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 21 September 2021 Source: European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): H.A. Breinbauer, M. Eyzaguirre, D. Herrero, P.H. Delano View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Assessment of Proton Resonance Frequency Shift Magnetic Resonance Thermography Imaging Quality for Head and Neck Tumors

xlomafota13 shared this article with you from Inoreader Assessment of Proton Resonance Frequency Shift Magnetic Resonance Thermography Imaging Quality for Head and Neck Tumors Via ear nose throat Ear Nose Throat J. 2021 Sep 22:1455613211043673. doi: 10.1177/01455613211043673. Online ahead of print. NO ABSTRACT PMID:34547952 | DOI:10.1177/01455613211043673 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Menopause and its Effect on Voice

xlomafota13 shared this article with you from Inoreader Menopause and its Effect on Voice Via Otolaryngology Indian Abstract This study was designed to study the impact of menopause on voice quality. Cross-sectional Observational study with a total of 100 subjects. All subjects underwent biochemical analysis which included thyroid function tests, estrogen levels, progesterone levels and underwent voice analysis using the VAUGHMI voice analyser software. 50 postmenopausal females as cases and 50 premenopausal females as controls were taken for the study. The females were of the age group 35–55 yrs in order to remove age as confounding factor. The primary outcome measure was Total score, calculated based on harshness, hoarseness and breathiness. The postmenopausal females had a poorer voice quality than the premenopausal females (Total score 1.62 vs 2.48, p < 0.001). There was a significant difference between the fundamental frequency and pitch and perturbation in frequency of the postmenopausal females as compared to premenopausal females. The difference in the pertu rbation in the intensity of the voice was not significant. No linear correlation could be established between the voice quality and oestrogen or progesterone levels but the intergroup variation of the two parameters was significant. The premenopausal females have better voice quality than postmenopausal females. The relationship between hormonal level and voice quality couldn't be established. Further studies are required to assess the relation of hormone levels & voice quality with the possibility of exploring voice cosmesis. Level of Evidence Level 3. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hyperbilirobinemia and Its Effect on Auditory Perception and Speech Intelligibility in Cochlear Implanted Children (Cochlear Implantation Outcomes in Children Who Have Experienced Hyperbilirobinemia)

xlomafota13 shared this article with you from Inoreader Hyperbilirobinemia and Its Effect on Auditory Perception and Speech Intelligibility in Cochlear Implanted Children (Cochlear Implantation Outcomes in Children Who Have Experienced Hyperbilirobinemia) Via Otolaryngology Indian Abstract The goal of this study was to investigate the probable difference in auditory perception and speech intelligibility performance amongst cochlear implanted children who experienced hyperbilirubinemia or auditory neuropathy in comparison to the cochlear implanted children with unknown etiology for hearing loss. This case–control study was carried out on 106 cochlear implanted children with mean age of 32.36 ± 11.98 months who were purposively selected and allocated into four groups. Out of the total, 30 had no specific etiology for hearing loss, while the others had experienced auditory neuropathy or hyperbilirubinemia with/without blood exchange. The auditory perception and speech intelligibility performance of all the participants who had received auditory verbal therapy were assessed after 6 and 12 months of rehabilitation. Then, the data was analyzed, using the Statistical Package for Social Sciences-version 21(SPSS-21). Results indicated poor audit ory perception and speech intelligibility performance of the cochlear implanted children with hyperbilirubinemia and blood exchange (P ≤ 0.05), while the participants in the control group with no specific etiology for hearing loss, the children with hyperbilirubinemia with no blood exchange, and those who suffered from auditory neuropathy performed better, respectively. Also, a significant correlation between auditory neuropathy and hyperbilirubinemia was observed. Despite lower improvement of auditory perception and speech intelligibility of the hearing impaired children who were experiencing moderate to severe degrees of hyperbilirubinemia or auditory neuropathy, cochlear implantation is highly recommended not only for children with unknown etiology for severe hearing loss but also for this group of hearing impaired children. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pilomatrixoma and its Imitators

xlomafota13 shared this article with you from Inoreader Pilomatrixoma and its Imitators Via ear nose throat Ear Nose Throat J. 2021 Sep 22:1455613211044778. doi: 10.1177/01455613211044778. Online ahead of print. ABSTRACT Introduction: Pilomatrixomas are benign neoplasms derived from hair follicle matrix cells. They are among the most common soft tissue head and neck tumors of childhood. Pilomatrixomas are typically isolated, slow-growing, firm, nontender masses that are adherent to the epidermis but mobile in the subcutaneous plane. This clinical presentation is so characteri stic that many experienced surgeons will excise suspected pilomatrixomas without prior imaging. We reviewed the results of this approach to determine whether physical examination alone differentiates pilomatrixomas from other similar soft tissue lesions of the pediatric head and neck. Methods: Computerized review of all pilomatrixomas over a 20-year period in a single academic pediatric otolaryngology practice. Results: 18 patients presented to our pediatric otolaryngology practice between 2001 and 2021 with historical and physical findings consistent with pilomatrixoma. Of the 18 patients, 7 were male and 11 were female. Ages ranged from 1.5 to 14 years, with a mean of 7.5 years. Most of the lesions (12) were located in the head and face, while the rest (6) were found in the neck. All patients were treated with complete surgical excision. Pathology confirmed pilomatrixoma in 15 patients. The remaining 3 children were found to have an epidermal inclusion cyst, a ruptur ed trichilemmal cyst, and a giant molluscum contagiosum lesion, respectively. One additional patient presented with a small lesion of the auricular helix that was thought to be a dermoid cyst, but proved to be a pilomatrixoma on histologic examination. Discussion: As pilomatrixomas are common and have a very characteristic presentation, surgical excision without prior diagnostic imaging will lead to correct treatment in the majority of cases. High resolution ultrasonography can help to confirm the diagnosis preoperatively, but is not definitive in large case series. Most of the cystic lesions that imitate pilomatrixoma will ultimately require surgical excision. PMID:34549614 | DOI:10.1177/01455613211044778 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.