Outcomes of Acoustic and Linguistic Performances Following Cochlear Implantation in Large Vestibular Aqueduct Syndrome (LVAS)

xlomafota13 shared this article with you from Inoreader Outcomes of Acoustic and Linguistic Performances Following Cochlear Implantation in Large Vestibular Aqueduct Syndrome (LVAS) Via Otolaryngology Indian Abstract Aim: This study aims to collate the outcomes in acoustic and linguistic performances after cochlear implantation in LVAS. Methods: In a hospital-based prospective interventional study, seven prelingual children with bilateral profound sensorineural hearing loss (SNHL) with LVAS were recruited. They underwent unilateral cochlear implantation between December 2013 and December 2015 in the Department of Otorhinolaryngology and Head Neck Surgery at a tertiary care center. Outcomes of auditory and speech performances were assessed in the form of revised categories of auditory perception (CAP), infant toddler meaningful auditory integration scale (IT-MAIS) and speech intelligibility rating (SIR) scores preoperatively, at one and two years follow up. Results: The mean age of implantation was 4 years. The median revised CAP, IT-MAIS, and SIR scores after one and two years of follow-up were 6, 27, 3, and 11, 36, 5 respectively. The mean follow-up duration was 21 .3 months. Conclusion: Pre op median revised CAP, IT-MAIS, and SIR scores of 0, 1, 1 showed improvement to 11, 36, 5 at two years follow up which was statistically significant. Hence, we conclude that good functional outcomes post-operatively advocate the significance of cochlear implantation in LVAS. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Comparative Study of Treatment Outcomes of Music Therapy, Tinnitus Maskers and Pharmacotherpy in Chronic Subjective Tinnitus

xlomafota13 shared this article with you from Inoreader A Comparative Study of Treatment Outcomes of Music Therapy, Tinnitus Maskers and Pharmacotherpy in Chronic Subjective Tinnitus Via Otolaryngology Indian Abstract Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. This study aimed to compare the outcome of music therapy, tinnitus maskers and pharmacotherapy on patients with chronic tinnitus, to observe and analyse the etiological factors of tinnitus and to find out whether music can be used as an active listening mode by which tinnitus perception can be decreased. This was a comparative longitudinal study involving 90 patients with chronic tinnitus who were randomly assigned to 3 groups of 30 each: Group A (Music therapy), Group B (Pharmacotherapy) and Group C (Tinnitus masker). After a detailed clinical history and examination, Tinnitus Handicap Inventory and Visual Analogue Scores were recorded both prior to and following therapy, and patient were followed up monthly up to 2 months. There is a significant difference in the mean THI score (p� �= 0.002) and mean VAS(p = 0.0006) at 2 months follow up in patients treated with Music therapy and patients had a satisfactory outcome after music therapy and did not require any further treatment. Patients in pharmacotherapy and hearing aid group had a good clinical improvement but mean THI and mean VAS score was not statically significant. It was also noticed that loud noise exposure and hypertension were main etiological factors in 37.77% and 26% of patients respectively. Music therapy appears to be an effective and cost-efficient mode of therapy for chronic tinnitus and could be suitable for widespread implementation for patients with tinnitus of varying severity. Pharmacotherapy and hearing aid application in the treatment of tinnitus has good outcome in our study but requires long term treatment and follow up. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer

xlomafota13 shared this article with you from Inoreader Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021. ABSTRACT The transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In stark contrast, sumoylation-deficient ETV1 was repressed in its ability to stimulate the MMP1 promoter and to cooperate with a histone demethylase, JmjC domain-containing 2A (JMJD2A), in LNCaP prostate cancer cells. Mutation of sumoylation sites enhanced the ability of ETV1 to interact with the histone deacetylase (H DAC) 1, but had basically no impact on complex formation with HDAC3 or JMJD2A. Further, compared to non-sumoylated ETV1, its sumoylated forms were less able to bind to the transcription factor, SMAD family member 4. Lastly, in contrast to wild-type ETV1, sumoylation-deficient ETV1 repressed LNCaP cell growth. Altogether, these data suggest that sumoylation modulates ETV1 function in a cell type-specific manner, possibly by altering the spectrum of transcriptional cofactors being recruited. Notably, SUMO pathway components SUMO1, ubiquitin-like modifier activating enzyme 2 and ubiquitin conjugating enzyme 9 were upregulated in prostate tumors, implying that enhanced sumoylation indeed promotes ETV1's oncogenic activity during prostate cancer formation. PMID:34367411 | PMC:PMC8339722 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle

xlomafota13 shared this article with you from Inoreader Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021. ABSTRACT Subchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serous exudate, fibrous tissue, and vascular-rich granulation tissue in the marrow space. In addition, a lower signal intensity line was observed within the BML in all cases on T1 MRI. Histologically, this line showed thickened bone trabeculae accompanied by fibrovascular tissue in two cases, while the other two cases sh owed formation of woven bone trabeculae around the original fractured bone trabeculae indicating the presence of another fracture in the bone marrow space. In summary, BML in SIF was considered to be a secondary phenomenon resulting from a subchondral fracture. PMID:34367413 | PMC:PMC8339717 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability

xlomafota13 shared this article with you from Inoreader ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jul 15;14(7):845-854. eCollection 2021. ABSTRACT A Disintegrin and metalloproteinase 17 (ADAM17) was proposed to cooperate with NF-κB p65, promoting tumorigenesis and progression of several human cancers. However, the role of ADAM17 remains unknown in human esophageal squamous cell carcinoma (ESCC). In this study, gene expression analyses and cell viability assays suggested that knockdown of ADAM17 suppressed ESCC cell viability. Gene expression analyses and ChIP-qPCR revealed that NF-κB p65 positively regulated ADAM17 expression by binding to the ADAM17 promoter. Rescue experiments showed that overexpression of ADAM17 in NF-κB p65-depleted ESCC cells restored cell viability. In addition, western blot analyses and ChIP-qPCR indicated that ADAM17 was responsible for the persistent activation of NF-κB p65 and contributed to ADAM17 expression in ESCC cells. In conclusion, we propose that ADAM17-activated NF -κB p65 signaling positively regulates ADAM17 expression, and facilitates ESCC cell viability. PMID:34367416 | PMC:PMC8339723 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Inflammation in COVID-19: from pathogenesis to treatment

xlomafota13 shared this article with you from Inoreader Inflammation in COVID-19: from pathogenesis to treatment Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021. ABSTRACT The coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were > 163 million confirmed cases of COVID-19 and the disease has claimed > 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review gives an overview of the role of inflammation in COVID-19. It also critically examines the various treatment approaches that target the immune system and inflammation in COVID-19, as well as highlights the key findings in the numerous studies conducted thus far. PMID:34367415 | PMC:PMC8339720 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature

xlomafota13 shared this article with you from Inoreader Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021. ABSTRACT Rosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease. PMID:34367414 | PMC:PMC8339718 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

CDC6 is a possible biomarker for hepatocellular carcinoma

xlomafota13 shared this article with you from Inoreader CDC6 is a possible biomarker for hepatocellular carcinoma Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jul 15;14(7):811-818. eCollection 2021. ABSTRACT OBJECTIVE: Research has proven that the expression of CDC6 is tightly related to tumorigenesis and progression of various tumors. However, the effects of CDC6 in hepatocellular carcinoma remain uncertain. The main purpose of this research is to explore this relationship. METHODS: We assessed the expression levels of CDC6 in a serious of cancers from GEPIA database. The expression of CDC6 in hepatocellular carcinoma tissue and normal liver tissue was compared, and further assessed by immunohistochemical staining. Graphpad software was performed for data analysis, and t-test and χ2 analysis were used to investigate the role of CDC6 in hepatocellular carcinoma. RESULTS: The expression level of CDC6 was significantly higher in malignant carcinoid, melanoma, urothelial tumor, and hepatocellular carcinoma in the GEPIA online database. It was related to clinical progression of hepatocellular carcinoma. We found that the expression of CDC6 was correlated with tumor size (P=0.018) and the number of tumor nodes (P=0.003), but not with age, gender and AFP value (P>0.05). CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma. PMID:34367412 | PMC:PMC8 339721 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Laryngeal Applications of Platelet Rich Plasma and Platelet Poor Plasma: A Systematic Review

xlomafota13 shared this article with you from Inoreader Laryngeal Applications of Platelet Rich Plasma and Platelet Poor Plasma: A Systematic Review Via Journal of Voice Platelet rich plasma (PRP) and platelet poor plasma (PPP) are regenerative therapies that offer the potential for improving care for disorders of the larynx. The laryngeal applications of these substances have been examined in both animals and humans. The goal of this systematic review is to examine the various applications of PRP and PPP in laryngology, assess the protocols for preparation and application of these substances and evaluate the outcomes and complications in both humans and animals. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Unusual Cause of Laryngeal Dyspnea

xlomafota13 shared this article with you from Inoreader An Unusual Cause of Laryngeal Dyspnea Via Journal of Voice Medialization laryngoplasty with autologous fat (MLA) is indicated in some patients with glottic insufficiency. The approach is usually safe but long-term complications are poorly described. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radial Forearm Free Flap Reconstruction of Glossectomy Defects Without Tracheostomy

xlomafota13 shared this article with you from Inoreader Radial Forearm Free Flap Reconstruction of Glossectomy Defects Without Tracheostomy Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Aug 8:34894211038254. doi: 10.1177/00034894211038254. Online ahead of print. ABSTRACT OBJECTIVES: To assess the feasibility of radial forearm free flap (RFFF) reconstruction of glossectomy defects without tracheostomy tube (TT). METHODS: Retrospective review of patients with at least oral tongue defects who underwent RFFF reconstruction. Pre- and intra-operative factors were documented. Post-operative respiratory complications included in ability to extubate, pneumonia, or need for re-intubation or TT within 30 days. RESULTS: Twenty-one patients underwent RFFF reconstruction without TT, and 36 patients with TT. The average hospital length of stay was 1.5 days shorter in those without TT (P < .01). Two patients who underwent TT placement experienced a respiratory complication (P = .27). There were no respiratory complications among those without TT. After multivariate analyses, large tongue base defect (>25% resection, P < .001) and bilateral neck dissection (P < .001) were independently associated with TT placement. CONCLUSIONS: In our experience, RFFF reconstruction of glossectomy defects is feasible without TT among selected patients with small tongue base defects (≤25% resection) and unilateral neck dissection. PMID:34369181 | DOI:10.1177/00034894211038254 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Parental Views on the Role of Social Media in Pediatric Otolaryngology

xlomafota13 shared this article with you from Inoreader Parental Views on the Role of Social Media in Pediatric Otolaryngology Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Aug 8:34894211037413. doi: 10.1177/00034894211037413. Online ahead of print. ABSTRACT OBJECTIVE: Social media is playing an increasingly important role in medicine as a tool for patients and their families to find information and connect with others. The goal of this study is to understand parental views on if and how social media should be incorporated into pediatric otolaryngology by physicians and hospitals. METHODS: A survey was distr ibuted to parents of pediatric otolaryngologic patients to assess views on professional social media use by physicians and hospitals. The proportion of parents who answered with specific responses in the survey was computed using the SPSS frequency analysis function. RESULTS: One hundred five parents completed the survey. Ninety-six percent of respondents use social media, of which 92% use social media at least once a day (n = 93). Eighty-five percent of respondents said they definitely or probably would visit their physician's professional social media page (n = 90). Seventy-four percent would be interested in obtaining more information about the physician (n = 76). Forty-one percent would be interested in patient stories (n = 76). Twenty-eight percent would visit out of curiosity (n = 76). Twenty-six percent would want to gather more information about the hospital (n = 76). Seventeen percent would want to connect with other patients and their family members (n = 76). Sixty-s even percent of respondents believe it is important for physicians to have a professional social media page, and 79% of respondents believe it is important for hospitals to have a public social media page (n = 93). CONCLUSION: The vast majority of parents of pediatric otolaryngologic patients use social media regularly and would want to gather information about their physician and hospital through social media. Therefore, physicians and hospitals should consider using social media as a valuable tool to connect with and relay information to patients and their family members. PMID:34369201 | DOI:10.1177/0003489421 1037413 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.