Linguistic adaptation and validation of the voice handicap index (VHI)-30 in patients with dysphonia into Russian

xlomafota13 shared this article with you from Inoreader Linguistic adaptation and validation of the voice handicap index (VHI)-30 in patients with dysphonia into Russian Via Polyps Vestn Otorinolaringol. 2021;86(3):20-27. doi: 10.17116/otorino20218603120. ABSTRACT Purpose of the study is to assess the internal consistency, reliability of retesting and clinical reliability of the Russian version of the Voice Handicap Index (VHI)-30 questionnaire. MATERIAL AND METHODS: It is prospective observational study. The original English version of the VHI-30 questionnaire was translated into Russian by two independent researchers (professional translators). The final Russian version (VHI-30rus) was formulated by a third researcher (otorhinolaryngologist) on the basis of these two translations, and then translated back into English. The 181 participants were included in this study. The main group patients (n=91) were additionally divided into subgroups in accordance with the form of dysphonia: 65 (71.4%) patients had functional and organic dysphonia, 8 (8.8%) had chronic inflammatory diseases of the larynx, 7 (7.7%) - benign neoplasms of the larynx (singing nodules, polyps, cysts), 11 (12.1%) - unilateral laryngeal paralysis. The control group consisted of 90 people without voice disorders. Internal consistency (Cronbach's α coefficient), retest reliability (intraclass correlation coefficient (ICC) VHI-30, comparison of VHI-30 indicators of patients and studied control group (Mann-Whitney U-test, Kruskal-Wallis test) and correlation with the overall severity of dysphonia (Spearman's ρ rank correlation coefficient) were determined. RESULTS: In the patient group, we observed excellent internal consistency for VHI-30rus (α=0.95) and good internal consistency for all VHI-30rus subscales: physical (α=0.88), functional (α=0.88), and emotional (α=0.88). The intraclass correlation coefficient (ICC) indicated high retest reliability for patients (0.99) and control group subjects (0.84). The 30-item mean total values for patients with dysphonia were statistically significantly higher tha n for control group participants (p<0.001). A correlation was found between the overall VHI-30rus value and the overall severity of dysphonia (ρ=0.748, p<0.001). In the patient's group, female and male participants showed a statistically insignificant difference in the total value of VHI-30rus (Mann-Whitney U-test, p<0.001). There was a correlation in terms of VHI-30rus indicators in different subgroups of the patient group and the control group (Spearman's correlation coefficient: functional dysphonia - 0.942; chronic laryngitis - 0.756; unilateral laryngeal paralysis - 0.888; benign neoplasms - 0.982; control group studied - 0.882). CONCLUSION: As a result of this study, the VHI-30 questionnaire was translated from English into Russian for use in the Russian-speaking environment. The study showed good internal consistency, retest reliability, and clinical validity for the Russian version of the VHI-30rus questionnaire. The VHI-30rus ques tionnaire can be recommended for use in clinical practice for patients with dysphonia. PMID:34269019 | DOI:10.17116/otorino20218603120 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of three-dimensional-printed template-guided and traditional implantation of 125I seeds for gynecological tumors: A dosimetric and efficacy study

xlomafota13 shared this article with you from Inoreader Comparison of three-dimensional-printed template-guided and traditional implantation of <sup>125</sup>I seeds for gynecological tumors: A dosimetric and efficacy study Via radioactive iodine J Cancer Res Ther. 2021 Jul;17(3):688-694. doi: 10.4103/jcrt.JCRT_1565_20. ABSTRACT OBJECTIVE: The objective of the study was to compare the dose parameter and clinical efficacy of three-dimensional-printed template (3D-PT)-guided and traditional 125I seed implantation in treatment of gynecological tumors. MATERIALS AND METHODS: A total of 28 patients with gynecological tumors treated with radioactive seed implantation in Hebei General Hospital from January 2016 to December 2018 were retrospectively analyzed. Twelve patients (template group) were guided by 3D-PT and the remaining 16 patients (traditional group) were guided by computed tomography (CT) with traditional technique. Preoperative treatment plan (preplan) was completed through a treatment planning system. In the template group, 3D-PT was printed according to preplan and seeds were implanted under the guidance of 3D-PT and CT. In the traditional group, seeds were implanted under the guidance of single CT directly according to the preplan. Postoperative verification plan (post-plan) was completed. Dose-volume histogram (DVH) was calculated and D80, D90, V90, V100, and V150 were obtained according to DVH. Then, deviation of the dosimetric parameters D80, D90, V90, V100, and V150 between the preplan and postplan were compared within the two groups. The difference and percentage of difference of the above dosimetric parameters between the preplan and postplan within the two groups were c alculated using the formula Xd = Xpost-plan- Xpre-plan, and Xd% = (Xpost-plan- Xpre-plan)/Xpre-plan × 100%. Doses were calculated to determine whether the differences there were statistically significant. Efficacy evaluation was completed according to RECISIT 1.1. Local control rate and effective rate of 2-months postplan were compared between the two groups. Survival analysis was completed by the Kaplan-Meier method. The patients were followed up for 12 months, and their survival rate was calculated and compared. RESULTS: There was no significant difference between the two groups for all the parameters, except for D80 of the preplan and postplan in the traditional group (P = 0.000). All the differences and percentage of difference were calculated and it was found that the Xd difference of D80 (P = 0.035), D90 (P = 0.023), V90 (P = 0.047), V100 (P = 0.032), and V150 (P = 0.031), as well as the Xd% difference of D80 (P = 0.032), D90 (P = 0.034), V90 (P = 0.042), V100 (P = 0.036), and V150 (P = 0.044) of the two groups was statistically significant, thus indicating that the dosimetric parameter fluctuation in the template group was more stable. The result of the curative effect after 2 months were as follows: the local control rate and effective rate of the template group were 100% (12/12) and 83.3% (10/12), while those of the traditional group were 100% (16/16) and 81.2% (13/16). There was no statistically significant difference in the curative effect between the two groups. After 6-27 months (median = 12 months) of follow-up, the median survival time of the template group and traditional group were 17 (10-23) and 16 (11-20) months, respectively, and the 1-year overall survival rate was 63% and 79% (P = 0.111), respectively, with no statistically significant difference observed. CONCLUSION: 3D-PT-guided 125I seed implantation is safe and ef fective in the treatment of gynecological tumors. PMID:34269300 | DOI:10.4103/jcrt.JCRT_1565_20 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Characterization of Primary Muscle Tension Dysphonia Using Acoustic and Aerodynamic Voice Metrics

xlomafota13 shared this article with you from Inoreader Characterization of Primary Muscle Tension Dysphonia Using Acoustic and Aerodynamic Voice Metrics Via Journal of Voice The objectives of this study were to (1) identify optimal clusters of 15 standard acoustic and aerodynamic voice metrics recommended by the American Speech-Language-Hearing Association (ASHA) to improve characterization of patients with primary muscle tension dysphonia (pMTD) and (2) identify combinations of these 15 metrics that could differentiate pMTD from other types of voice disorders. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cepstral Measurements: A Comparison of Results Between Singing and Non-Singing Individuals

xlomafota13 shared this article with you from Inoreader Cepstral Measurements: A Comparison of Results Between Singing and Non-Singing Individuals Via Journal of Voice To analyze and compare cepstral measurements in singing and non-singing men and women to understand if vocal adaptations of singers reflect greater cepstral measurement results. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Death-associated protein kinase 1 correlates with podocyte apoptosis and renal damage and can be mediated by miR-361

xlomafota13 shared this article with you from Inoreader Death-associated protein kinase 1 correlates with podocyte apoptosis and renal damage and can be mediated by miR-361 Via Cellular and Molecular Biology Histol Histopathol. 2021 Jul 16:18358. doi: 10.14670/HH-18-358. Online ahead of print. ABSTRACT BACKGROUND: Herein, we aimed to determine whether DAPK1 and its post-transcriptional regulator miR-361 were implicated in high glucose (HG)-induced podocyte injury and renal damage in db/db mice. MATERIALS AND METHODS: Podocytes were incubated with normal glucose (NG; 5 mM) or HG (30 mM). Podocyte apoptosis was evaluated using TUNEL staining. Lentiviral-delivered specific short hairpin RNA (shRNA) was designed to silence DAPK1 expression in podocytes. miR-361 agomir was administrated by tail intravenous injection in db/db diabetic mice to investigate the renoprotection of miR-361 in vivo. RESULTS: Exposure of podocytes to HG led to a significant increase in DAPK1 mRNA and protein levels and a decrease in miR-361 expression levels. Knockdown of DAPK1 attenuated HG-triggered growth inhibition, apoptosis, DNA damage and cell membran e damage in podocytes. Mechanically, DAPK1 was a direct target of miR-361. Transfection with miR-361 mimics into podocytes resulted in a significant decrease in the DAPK1 protein expression level. In addition, HG-induced the up-regulation of the DAPK1 protein expression level in podocytes was restrained by miR-361 mimics transfection. Intriguingly, overexpression of DAPK1 in HG-stimulated podocytes muted miR-361-mediated cytoprotection, including anti-apoptosis, resistance to DNA and membrane damage. In vivo, overexpression of miR-361 protected against hyperglycemia-induced podocyte loss, tubular atrophy and interstitial fibrosis in the kidney of db/db mice. Moreover, overexpression of miR-361 inhibited the protein expression of DAPK1 in the kidney of db/db mice. CONCLUSION: Our research presented a novel mechanism of HG-induced podocyte damage or renal lesion, supporting the miR-361/DAPK1 signaling pathway that could be used as a potential therapeutic target for the treatment of DN. PMID:34269397 | DOI:10.14670/HH-18-358 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of adenoidectomy or adenotonsillectomy on the cardiovascular system in children: a meta-analysis

xlomafota13 shared this article with you from Inoreader Effects of adenoidectomy or adenotonsillectomy on the cardiovascular system in children: a meta-analysis Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jul 16. doi: 10.1007/s00405-021-06986-0. Online ahead of print. ABSTRACT OBJECTIVE: Adenoid or adenotonsillar hypertrophy (AATH) causes upper airway obstruction, leading to cardiovascular complications. This meta-analysis was conducted to evaluate the efficacy of adenoidectomy or adenotonsillectomy (AATE) on the cardiovascular system. METHODS: Using the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE databases, we identified studies involving a comparison of preoperative and postoperative cardiovascular function in children with AATH. The Cochrane Collaboration's Review Manager 5.3 software was used for meta-analysis. RESULTS: A total of 13 studies with 706 participants were included. The meta-analysis demonstrated a significant reduction in mean pulmonary artery pressure (mPAP) of patients after AATE compared with preoperative values. The left ventricular myocardial functi on index (LVMPI) and the right ventricular myocardial function index (RVMPI) showed a significant decrease after the operation. Moreover, AATE prominently increased left ventricular ejection time (LVET) and right ventricular ejection time (RVET) and reduced the left ventricular interventricular septum diameter (LVIVSD) and the right ventricular end-diastolic diameter (RVedD). There was no significant difference in mPAP, LVMPI, RVMPI, LVET, RVET, LVIVSD, and RVedD between postoperative patients and healthy children (P > 0.05). CONCLUSION: AATE can improve cardiovascular function in pediatric patients with AATH. Specifically, it reduces mPAP and LVMPI/RVMPI in pediatric patients. Furthermore, AATE increases LVET and RVET and reduces LVIVSD and RVedD. PMID:34269887 | DOI:10.1007/s00405-021-06986-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Endolaryngeal resection of the larynx for adenocystic cancer

xlomafota13 shared this article with you from Inoreader Endolaryngeal resection of the larynx for adenocystic cancer Via Vestnik otorinolaringologii Vestn Otorinolaringol. 2021;86(3):134-136. doi: 10.17116/otorino202186031134. ABSTRACT Adenocystic carcinoma accounts for 3-5% of all malignant neoplasms of the head and neck organs. Due to the rarity of detecting this cancer in the larynx, treatment options are still controversial: surgery with postoperative radiation therapy or surgery alone. Patient A., 64 years old, turned to the City Clinical Oncological Hospital No. 1 in October 2019 with complaints of moderate pain when swallowing, sensation of a foreign body. Fibrolaryngoscopy revealed an exophytic form of growth bright red color formation with a small tuberous surface up to 12 mm in size in the area of the free left edge of the epiglottis. There was a thickening of the pharyngeal-epiglottis fold. Histological examination revealed adenocystic cancer. Diagnosed with Laryngeal cancer with cT1N0M0. On December 23, 2019, endolaryngeal resection of the larynx was performed us ing an operating microscope in the volume R0. This observation is of interest both in morphological terms (extremely rarely detected cancer of the larynx) and in terms of treatment (an organ-preserving operation was performed - endolaryngeal resection of the larynx). PMID:34269037 | DOI:10.17116/otorino202186031134 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Features of tinnitus in older patients with autonomic dysfunction

xlomafota13 shared this article with you from Inoreader Features of tinnitus in older patients with autonomic dysfunction Via Vestnik otorinolaringologii Vestn Otorinolaringol. 2021;86(3):9-13. doi: 10.17116/otorino2021860319. ABSTRACT OBJECTIVE: To establish the features of tinnitus in older age patients with autonomic dysfunction. MATERIAL AND METHODS: We examined 94 patients aged 60 to 93 years (average age is 75.4±3.2 years). Patients with an imbalance of the autonomic nervous system were identified according to the questionnaire of A.M. Wayne and Kerdo's autonomic index. The questionnaires assessing the strength of subjective ear noise, the psychoemotional state of patients, the impact of tinnitus on various spheres of life were used in this study. RESULTS: It was revealed that more than 50% of patients of older age groups with tinnitus had a dysfunction of the autonomic nervous system. Patients with parasympathicotonia more often noted bilateral persistent subjective ear noise than patients with sympathicotonia. CONCLUSIONS: Autonomic dysfunction could be the ca use of sleep disturbances, psychoemotional disorders and a decrease in the quality of life. PMID:34269017 | DOI:10.17116/otorino2021860319 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Features of bacterial microbiota in acute purulent otitis media in children

xlomafota13 shared this article with you from Inoreader Features of bacterial microbiota in acute purulent otitis media in children Via Vestnik otorinolaringologii Vestn Otorinolaringol. 2021;86(3):4-8. doi: 10.17116/otorino2021860314. ABSTRACT PURPOSE OF THE STUDY: The purpose is to study the spectrum of bacterial pathogens that cause acute purulent otitis media (APOM) in children of the Moscow region in modern conditions and assess their sensitivity to the main groups of antibiotics. MATERIAL AND METHODS: The study included 1.864 children who underwent examination and received treatment in the otorhinolaryngological department of Morozovskaya Pediatric Municipal Clinical Hospital in the period from 01 July 2018 to 31 June 2020 with a diagnosis of APOM. RESULTS: The study showed that the leading bacterial pathogens of APOM are Streptococcus pneumoniae (28.0%), Staphylococcus aureus (27.2%), Streptococcus pyogenes (22.2%), Haemophilus influenzae (7.8%), and Pseudomonas aeruginosa (6.5%). Attention is drawn to the increase in the level of resistance o f S. pneumoniae to oxacillin (11.64%). CONCLUSIONS: The data obtained indicate the feasibility and prospects of vaccination against pneumococcal infection as one of the ways to curb the spread of resistance of S. pneumoniae to antibacterial drugs. PMID:34269016 | DOI:10.17116/otorino2021860314 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Anatomical and functional results of ossiculoplasty with adjustable length titanium prostheses with and without hydroxyapatite

xlomafota13 shared this article with you from Inoreader Anatomical and functional results of ossiculoplasty with adjustable length titanium prostheses with and without hydroxyapatite Via Vestnik otorinolaringologii Vestn Otorinolaringol. 2021;86(3):14-19. doi: 10.17116/otorino20218603114. ABSTRACT OBJECTIVE: To compare the anatomical and functional results of the ossicular chain reconstruction with classic titanium adjustable prostheses and titanium adjustable prostheses with hydroxyapatite cap. MATERIAL AND METHODS: The 300 patients (360 cases) with chronic suppurative otitis media were examined and operated. The patients are divided into 2 groups. Group A included patients who received an ossicular prosthesis with a hydroxyapatite cap (90 cases with a partial prosthesis and 90 with a full one). Group B included patients who received prostheses without hydroxyapatitis (90 cases with a partial prosthesis and 90 with a complete one). The patients who received a prosthesis with a hydroxyapatite cap were divided into two subgroups, depending on the autotissue, which was placed between the prosthesis cap and the nontympanic membrane: this is an autocartilage plate or perichondrium/fascial graft. The follow-up period after surgery was 38.5±14.4 months (from 12 to 48 months). In the long-term postoperative period, the subjects were assessed the values of the bone-air gap (BAG), the consistency of the nontympanic membrane, and the presence of signs of extrusion of the prosthesis cap. Comparison of anatomical and functional results between patients with full and partial ossicular prostheses was performed separately. RESULTS: A good result in the form of a 20 dB or more dB BAG reduction was achieved in 82.2% of patients who received a partial prosthesis (85 patients in group A and 63 in group B), and in 57.8% of patients who received a complete prosthesis (45 patients in group A and 59 in group B). The BAG values in the long-term period after surgery did not statistically significantly differ between patients who received a prosthesis with a hydroxyapatite cap or a fully titanium one (p=0.939 for patients with fu ll prostheses and p=0.745 for patients with partial prostheses). The placement of cartilage or perichondrium/fascial graft between the hydroxyapatite prosthesis cap and the nontympanic membrane also did not affect the functional outcome (with full prostheses - p=0.651, with partial prostheses - p=0.142). CONCLUSION: It is possible to use ossicular prostheses with a hydroxyapatite cap without placing an autocartilaginous plate between the nontympanic membrane and the cap of the prosthesis. In the long term period, functional and anatomical results with hydroxyapatite cap prostheses do not differ statistically significantly from those with all-titanium prostheses. PMID:34269018 | DOI:10.17116/otorino20218603114 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Epidemiological study of hearing impairments in children: prevalence, structure, amplification, and social factors

xlomafota13 shared this article with you from Inoreader Epidemiological study of hearing impairments in children: prevalence, structure, amplification, and social factors Via Vestnik otorinolaringologii Vestn Otorinolaringol. 2021;86(3):28-35. doi: 10.17116/otorino20218603128. ABSTRACT For the first time, a detailed epidemiological study of hearing impairments (HI) in the children's population of St. Petersburg (n=3098) was conducted. The data on the incidence of HI in children, the distribution of children depending on the degree of hearing loss, HI type, the presence of additional disorders, risk factors for hearing loss were obtained. Only 19% of children with HI were diagnosed in accordance with modern requirements of early care - at the age of 3 months. In children who underwent universal newborn hearing screening the average age of diagnosis was significantly lower than in children who were not screened. Only 54% of HI children use hearing aids (HA) or cochlear implants. Among the children who do not use HA, the main number is children with mild and moderate hearing loss, unilateral hearing loss and otitis media with effu sion. A significant part of them should be considered as candidates for amplification according to current recommendations. The average interval between diagnosis and amplification was 15.7 months. Only 5% of children from the entire population of children with HI received early intervention in accordance with the modern time standard: 1 month (detection) - 3 months (diagnosis) - 6 months (amplification). The problems of organizing an effective care for HI children and the directions of its development are discussed: improving newborn hearing screening; introduction the system of informing the citizens and doctors of related specialties (pediatricians, neurologists) in the field of prevention, diagnosis and rehabilitation of HI in children; expansion of genetic testing of children; reducing time of waiting and improving the quality of HA provided to handicapped children. PMID:34269020 | DOI:10.17116/otorino20218603128 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.