Short‐ and long‐term outcomes of three‐dimensional printed surgical guides and virtual surgical planning versus conventional methods for fibula free flap reconstruction of the mandible: Decreased nonunion and complication rates

xlomafota13 shared this article with you from Inoreader Short‐ and long‐term outcomes of three‐dimensional printed surgical guides and virtual surgical planning versus conventional methods for fibula free flap reconstruction of the mandible: Decreased nonunion and complication rates Via Head & Neck Abstract Background To determine whether virtual surgical planning and three‐dimensional printed cutting guides (3D/VSP) improved radiographic bone union compared to conventional methods (CM) in fibula free flap (FFF) reconstruction of the mandibles. Methods Retrospective study from the years 2000–2018 at a tertiary hospital. Osseous union was evaluated by a radiologist blinded to each patient's treatment. Results Two hundred sixty patients who underwent FFF tissue transfer, 28 with VSP and 3D cutting guides. Bony union was not achieved in 46 (20%) patients who underwent CM compared to 1 (4%) of patients with VSP and guides (p = 0.036). FFF complication was significantly higher in CM with 87 patients (38%) compared to three patients (11%) in 3D/VSP (p = 0.005). Median time to bony union for patients who underwent CM was 1.4 years compared to 0.8 years in 3D/VSP. Conclusions 3D/VSP reduced the rate of radiographic nonunion and flap‐related complications in FFF reconstruction for mandibular defects. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The value of 68Gallium‐DOTATATE PET/CT in sinonasal neuroendocrine tumor management: A case series

xlomafota13 shared this article with you from Inoreader The value of 68Gallium‐DOTATATE PET/CT in sinonasal neuroendocrine tumor management: A case series Via Head & Neck Abstract Background 68Gallium‐DOTATATE (68Ga‐DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for 68Ga‐DOTATATE imaging in these patients. Methods We discussed the impact of 68Ga‐DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results 68Ga‐DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, 68Ga‐DOTATATE detected abnormal radiotracer uptake not present on 18F‐FDG PET/CT and identified a patient for treatment with 177Lu‐DOTATATE. Conclusions This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of 68Ga‐DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Development of a machine learning model for the prediction of nodal metastasis in early T classification oral squamous cell carcinoma: A SEER‐based population study

xlomafota13 shared this article with you from Inoreader Development of a machine learning model for the prediction of nodal metastasis in early T classification oral squamous cell carcinoma: A SEER‐based population study Via Head & Neck Abstract Background This study aimed to develop and compare machine learning (ML) based predictive models for lymph node metastasis (LNM) in early T classification oral squamous cell carcinoma (OSCC). Methods We used data from the Surveillance Epidemiology and End Results Database to develop and validate the predictive models for LNM in patients with T1, T2 OSCC. Using simple clinical and histopathological data, we developed six ML algorithms to predict LNM. The predictive performance of models was compared. Results The areas under the receiver operating characteristic curves (AUCs) of the six models ranged from 0.768 to 0.956. The best prediction performance was achieved with a XGBoost (AUC = 0.956). Permutation importance analysis showed that tumor size is the most important feature in predicting metastasis. Conclusions We developed a simplified and reproducible ML‐based predictive model for metastasis in early T classification OSCC that could be helpful for the decision of a treatment strategy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Assessment of different induction chemotherapy regimens in locally advanced nasopharyngeal carcinoma: A meta‐analysis

xlomafota13 shared this article with you from Inoreader Assessment of different induction chemotherapy regimens in locally advanced nasopharyngeal carcinoma: A meta‐analysis Via Head & Neck Abstract Background A Bayesian network meta‐analysis was performed to compare the efficacy and toxicities among different induction chemotherapy regimens in locally advanced nasopharyngeal carcinoma (LA‐NPC). Methods Electronic databases were searched for literature up to September 16, 2019. Two researchers independently selected the articles, evaluated the quality of the literature, and extracted and analyzed the data. Results There were no significant differences in survival outcomes, mucositis, or gastrointestinal adverse events among the four regimens. The probability of GP being the best induction scheme to improve OS was 43.7%. The completion rate of concurrent chemotherapy with the GP regimen was significantly reduced than the other three regimens. Conclusions The survival outcomes of the four regimens in LA‐NPC were comparable. Considering only OS, GP showed the highest probability of improving the survival of LA‐NPC, while it also affected the completion of concurrent chemotherapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere’s Disease with Non-Serviceable Hearing

xlomafota13 shared this article with you from Inoreader Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing Via Otolaryngology Indian Abstract To compare the effectiveness of high dose fixed alternate day intratympanic gentamicin with methylprednisolone in the treatment of patients with unilateral, intractable Meniere's disease with poor hearing. Randomized single blind prospective parallel group trial in a tertiary referral centre. Twenty-two patients with definite unilateral Meniere's disease with average pure tone thresholds worse than 50 dB in the affected ear were enrolled. Eleven patients were treated with intratympanic buffered gentamicin and the other eleven were administered intratympanic methylprednisolone (both 4 injections, 40 mg/ml, on alternate days). Patients were assessed pre-intervention, 3 months post intervention and subsequently followed up for 2–4 years. Both groups of patients had significant control of vertigo, DHI scores and THI scores after treatment while the functional scores in the methylprednisolone group was not better than the pre- treatment sco res in the long-term follow-up. 9 of 11(82%) patients in gentamicin group and 3 of 11(27%) patients in the methylprednisolone group achieved Class A vertigo control. The gentamicin group had better post intervention DHI scores (p = 0.016, 3 months and p = 0.046, long term) and Functional score (p = 0.014, 3 months and p = 0.05, long term). The hearing in both groups and THI scores, post intervention was similar between both groups. In patients with unilateral intractable MD with non-serviceable hearing, high fixed doses of both intratympanic gentamicin and methylprednisolone are effective in alleviating disease symptoms in long term follow-up. However, intratympanic gentamicin resulted in better control of vertigo, total DHI score and functional level scores than intratympanic methylprednisolone with no significant difference in hearing levels. Trail Registration Number Clinical Trials Registry of India (CTRI- REF/2016/10/012363) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Role of Diffusion-Weighted Magnetic Resonance Imaging in the Evaluation of Clinically Suspected Cholesteatoma Cases

xlomafota13 shared this article with you from Inoreader Role of Diffusion-Weighted Magnetic Resonance Imaging in the Evaluation of Clinically Suspected Cholesteatoma Cases Via Otolaryngology Indian Abstract To analyze the apparent diffusion coefficient (ADC) values of middle ear and mastoid lesions in Diffusion weighted Magnetic Resonance Imaging (DW-MRI) to arrive at a probable demarcating value to differentiate cholesteatoma from non-cholesteatomatous lesions. Accurate anatomic localization of the lesion was also done using High Resolution Computed Tomography (HRCT) temporal bone. The study cohort consisted of 30 patients who had undergone HRCT, DW-MRI and surgical intervention in clinically suspected cholesteatomatous lesions during the period August 2018 to August 2020.Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy values of HRCT and MRI in relation to intraoperative findings and histopathological findings (gold standard) were calculated and compared using the 2-sided McNemar's Chi Square test. Receiver operating characteristic (ROC) curve was used to predict the cut off value of ADC to differentiate be tween cholesteatoma and non cholesteatomatous lesions. Total patients were 30 out of which 15 were histopathologically proven cholesteatoma. MR DWI showed 100% sensitivity, 80% specificity, and 90% accuracy in diagnosing cholesteatoma compared to HPE. The probable cut off value of ADC in differentiating cholesteatoma from non-cholesteatomatous lesions was found to be < 1.226 × 10–3 mm2/s, statistically using ROC curve. HRCT showed 96.6% accuracy in identifying the location of the lesion. MR-DWI is a useful tool both individually and in combination with HRCT in the diagnosis of cholesteatomas with high accuracy. An ADC cut-off value could also significantly help increase the accuracy of diagnosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Rare Cause of Ortner’s Syndrome and a Case-Based Review of Literature

xlomafota13 shared this article with you from Inoreader A Rare Cause of Ortner's Syndrome and a Case-Based Review of Literature Via Otolaryngology Indian Abstract Ortner's syndrome refers to the compression of the recurrent laryngeal nerve by cardiovascular disorders of various etiologies. We describe a rare case of Ortner's syndrome caused by thoracic aorta aneurysm and a brief review of literature on this unusual cause of Ortner's syndrome. Hoarseness of voice due to the compression of recurrent laryngeal nerve by thoracic aorta aneurysm could be a harbinger of aneurysmal rupture. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A pediatric case of primary ciliary dyskinesia caused by novel copy number variation in PIH1D3

xlomafota13 shared this article with you from Inoreader A pediatric case of primary ciliary dyskinesia caused by novel copy number variation in <em>PIH1D3</em> Via Auris Nasus Larynx Publication date: Available online 31 March 2021 Source: Auris Nasus Larynx Author(s): Yifei Xu, Satoru Ogawa, Yuichi Adachi, Naoyuki Sone, Shimpei Gotoh, Makoto Ikejiri, Kaname Nakatani, Kazuhiko Takeuchi View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

High CT values relative to the brainstem differentiate inverted papillomas from nasal polyps

xlomafota13 shared this article with you from Inoreader High CT values relative to the brainstem differentiate inverted papillomas from nasal polyps Via Auris Nasus Larynx Publication date: Available online 31 March 2021 Source: Auris Nasus Larynx Author(s): Nao Sano, Shu Kikuta, Kenji Kondo, Tatsuya Yamasoba View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acute vestibulopathy with simultaneous bilateral involvement of the vestibulo-ocular reflex limited to the low-frequency range

xlomafota13 shared this article with you from Inoreader Acute vestibulopathy with simultaneous bilateral involvement of the vestibulo-ocular reflex limited to the low-frequency range Via Auris Nasus Larynx Publication date: Available online 31 March 2021 Source: Auris Nasus Larynx Author(s): Maiko Yamakawa, Kayoko Kabaya, Akina Fukushima, Shinobu Ito, Shinichi Iwasaki View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Decreased miRNA-320e correlates with allergy in children with otitis media with effusion

xlomafota13 shared this article with you from Inoreader Decreased miRNA-320e correlates with allergy in children with otitis media with effusion Via Auris Nasus Larynx Publication date: Available online 1 April 2021 Source: Auris Nasus Larynx Author(s): Paulina Adamczyk, Beata Narożna, Aleksandra Szczepankiewicz, Anna Bręborowicz, Beata Pucher, Michał Kotowski, Jakub Sroczyński, Agata Kałużna-Młynarczyk, Jarosław Szydłowski View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Delayed onset of tooth decay in a routine pediatric adenotonsillectomy

xlomafota13 shared this article with you from Inoreader Delayed onset of tooth decay in a routine pediatric adenotonsillectomy Via American Journal of Otolaryngology Publication date: Available online 31 March 2021 Source: American Journal of Otolaryngology Author(s): Prachi Patel, Matthew L. Rohlfing, Jessica R. Levi View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Papillary thyroid microcarcinomas that metastasize to lymph nodes

xlomafota13 shared this article with you from Inoreader Papillary thyroid microcarcinomas that metastasize to lymph nodes Via American Journal of Otolaryngology Publication date: Available online 31 March 2021 Source: American Journal of Otolaryngology Author(s): Ahmet Dirikoc, Abbas Ali Tam, Nurcan Ince, Didem Ozdemir, Oya Topaloglu, Afra Alkan, Aylin Kilic Yazgan, Reyhan Ersoy, Bekir Cakir View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.