Treatment of tracheo(broncho)malacia in children

xlomafota13 shared this article with you from Inoreader Treatment of tracheo(broncho)malacia in children Via oto-rhino-laryngologie Rev Med Liege. 2021 Mar;76(3):145-151. ABSTRACT Tracheomalacia (TM) is characterized by tracheal collapse due to an intrinsic anomaly resulting in a lack of rigidity of the cartilaginous rings and/or the posterior membrane during expiration, coughing or crying. It may also be secondary to external compression or acquired during endobronchial diseases. TM is commonly associated with other syndromes or airway abnormalities. Tracheomalacia can be localized or diffused and if the main bronchi are involved, the term of tracheobronchomalacia (TBM) is used. The most common symptoms include expiratory stridor, barking cough and recurrent respiratory tract infections. If tracheal weakness is severe, Acute Life Threating Events (ALTE) or Brief Resolved Unexplained Event (BRUE) can occur. While mild forms usually do not require any treatment, severe TBM may require medical and/or surgical management. Amongst several possible treatments, including trache ostomy, noninvasive ventilation and airway stenting, the pexy surgical approach (posterior, anterior tracheopexy or aortopexy) is currently the favoured option. PMID:33682381 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Compensation of damage in cancerology

xlomafota13 shared this article with you from Inoreader Compensation of damage in cancerology Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 4:S0007-4551(21)00047-3. doi: 10.1016/j.bulcan.2020.11.021. Online ahead of print. ABSTRACT In a few situations, the consequences secondary to a carcinological pathology require an assessment of damages for compensatory purposes. This is particularly the case when liable parties have been found to be at cause of the disease: occupational pathologies in the case of inexcusable employer's fault, exposure to a radioactive risk, for example in the context of full compensation for damages suffered by the victims of nuclear experiments performed by France, or lastly, in the after-effects of late diagnosis. This article does not discuss the imputability of cancer pathologies to an event, but it proposes an adaptation of methods for assessing damages, in an attempt to provide full compensation for damages. PMID:33678407 | DOI:10.1016/j.bulcan.2020.11.021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Medium-term follow-up of patients treated with chimeric antigen receptor T cells (CAR T cells): Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)

xlomafota13 shared this article with you from Inoreader Medium-term follow-up of patients treated with chimeric antigen receptor T cells (CAR T cells): Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 4:S0007-4551(21)00041-2. doi: 10.1016/j.bulcan.2020.11.015. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T cells are a new class of anti-cancer therapy that involves manipulating autologous or allogeneic T cells to express a CAR directed against a membrane antigen. In Europe, tisagenlecleucel (Kymriah™) has marketing authorization for the treatment of relapsed / refractory acute lymphoblastic leukemia (ALL) in children and young adults, in addition to the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL); the marketing authorization for axicabtagene ciloleucel (Yescarta™) is for the treatment of relapsed / refractory high-grade B-cell lymphoma and for the treatment of primary mediastinal B-cell lymphoma. Both cell products are genetically modified autologous T cells directed against CD19. These recommendations, drawn up by a working group of the Francophone Society of Bo ne Marrow transplantation and cellular Therapy (SFGM-TC) relate to the management of patients and the supply chain: medium-term complications, in particular cytopenias and B-cell aplasia, nursing and psychological supportive care. In another work, we will address long-term monitoring, post-marketing authorization pharmacovigilance and issues relating to JACIE and regulatory authorities. These recommendations are not prescriptive; their aim is to provide guidelines for the use of this new therapeutic approach. The purpose of this workshop is to outline the organizational aspects of this new therapeutic approach. PMID:33678408 | DOI:10.1016/j.bulcan.2020.11.015 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Withholding or withdrawing life-sustaining treatments in acute oncology situations: History and regulatory aspects in France

xlomafota13 shared this article with you from Inoreader Withholding or withdrawing life-sustaining treatments in acute oncology situations: History and regulatory aspects in France Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 4:S0007-4551(21)00046-1. doi: 10.1016/j.bulcan.2020.11.020. Online ahead of print. ABSTRACT The management of oncology patients, especially hospitalized patients, can lead to almost daily discussions regarding therapeutic limitations. Here, we review the history and propose a summary of the texts framing the notion of "withholding and withdrawing life-sustaining treatment" in oncology practice in France. This decision is regulated by the Claeys-Léonetti Law of February 2, 2016 recommending a collegial discussion and its documentation in the medical record. The decision to withhold or withdraw life-sustaining treatments is the subject of discussion between the patient, his physicians and his family and may take place at any time during his management. The work of intensive-care physicians provides many useful recommendations for acute oncology situations, however articles specific for oncology practice are scarce; this is a topic that oncologists must take up. PMID:33678409 | DOI:10.1016/j.bulcan.2020.11.020 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A novel seven-gene panel predicts the sensitivity and prognosis of head and neck squamous cell carcinoma treated with platinum-based radio(chemo)therapy

xlomafota13 shared this article with you from Inoreader A novel seven-gene panel predicts the sensitivity and prognosis of head and neck squamous cell carcinoma treated with platinum-based radio(chemo)therapy Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 8. doi: 10.1007/s00405-021-06717-5. Online ahead of print. ABSTRACT PURPOSE: The aim of the study is to identify a reliable gene panel to predict the prognosis of HNSCC patients by integrated genomic analysis. METHODS: Co-expression gene networks were constructed by WGCNA using GSE113282 gene expression profile. The biological functional investigation was performed by GO and KEGG function enrichment analysis. The hub gene module was screened by PPI. The prognostic gene panel was established by Lasso regression analysis, and further progression-free survival (PFS) analysis was validated by Kaplan-Meier survival analysis using GSE102995 data. RESULTS: We identified 195 genes associated with the overall survival (OS) status (correlation coefficients: - 0.42, and p value: 2e-05) by WGCNA. These genes were enriched in immune-related cytokines and pathways analyzed by GO and KEGG. Among the 195 genes, the module (42 genes) with the highest score was screened by PPI. A novel seven-gene predictive panel (CD19, CD40LG, CD5, CXCR6, FPR2, NCAM1, and SELL) was established by Lasso regression analysis, and the area under ROC curve (AUC) for 3-year OS status was 0.8298 and 0.7571, respectively, in the training set and the test set. The PFS time of the low-risk patients was significantly longer than the high-risk patients (p < 0.0001; log-rank test) by further validation using GSE102995 data. CONCLUSION: The seven-gene panel may serve as a reliable predictive tool for HNSCC patients treated with platinum-based radio (chemo) therapy, and may be potential therapeutic targets for HNSCC patients. PMID:3368204 6 | DOI:10.1007/s00405-021-06717-5 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Two novel hepatic arterial variations in a living liver donor detected by multidetector computed tomography angiography

xlomafota13 shared this article with you from Inoreader Two novel hepatic arterial variations in a living liver donor detected by multidetector computed tomography angiography Via radiol anat Surg Radiol Anat. 2021 Mar 8. doi: 10.1007/s00276-021-02730-9. Online ahead of print. ABSTRACT PURPOSE: Considering that the knowledge of variations in the hepatic vascular structure is essential for hepatic surgery and liver transplantation, we aimed to present a rare case of the anatomic variation of arterial blood supply to the liver to help prevent complications and choose suitable donors. METHODS: We present a novel variant in this case report (living liver donor) , an accessory right hepatic artery (supplying segment 6) originating from the dorsal pancreatic artery and a middle hepatic artery (supplying segment 4) arising from the pancreaticoduodenal artery (first branch of the gastroduodenal artery). Preoperative diagnosis was made using computed tomography angiography (CTA) with multiplanar reformate (MPR) images, curved planar reformate (CPR), maximum intensity projection (MIP) images and three-dimensional volume renderings (3D VR). RESULTS: To the best of our knowledge, this is the first case in the English literature describing this type of variation. A search for new donors began since the living liver donor was not suitable due to the very thin segment 4 artery, posing potential risks for the donor and the thin segment 6 artery being a complicating factor for anastomosis. CONCLUSIONS: The preoperative knowledge of liver blood supply has great importance in planning surgery and transplantation. CTA, reformate and reconstruc tion techniques allow for the evaluation of difficult and complex anatomic variations. PMID:33682016 | DOI:10.1007/s00276-021-02730-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermis

xlomafota13 shared this article with you from Inoreader Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermis Via Experimental Dermatology Abstract Background Expression of microRNAs (miRNAs) is often dysregulated in several cancers, including non‐melanoma skin cancer (NMSC). Individuals with vitiligo possess a deregulated miRnome along with a lower risk of developing NMSCs. Objectives To understand the molecular basis underlying the lower incidence of NMSC observed in patients with vitiligo by investigating their miRNA‐regulated gene networks. Methodology We used data sets from our previously published studies on vitiligo epidermis to construct functional miRNA‐mRNA networks. MiRtarbase was used to fetch the experimentally validated targets of DE‐miRNAs. Protein‐protein interaction (PPI) networks were constructed with only those gene targets that demonstrated a pattern of inverse regulation with their upstream miRNAs. Oncogenic transcription factors (OTFs) that were upregulated in publicly available squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) microarray data were compared with that of vitiligo to decode skin cancer‐specific molecular signatures. Results Two PPI networks were constructed for the miRNA–mRNA interactions (230 down‐regulated targets of 5 up‐regulated miRNAs and 47 up‐regulated mRNAs targeted by 12 down‐regulated miRNAs). Pathway enrichment analysis identified RNA biogenesis and transport as well as cell adhesion to be perturbed in vitiligo. We further identified three significantly upregulated miRNAs, miR‐31‐5p, miR‐31‐3p and miR‐194‐3p in lesional epidermis that could negatively regulate seven oncogenic transcription factors, FOXC1, AR, SP1, YY1, GLI2, TP53 and RARA, known to be overexpressed in SCC or BCC. Conclusion We identified a perturbed miRNA‐regulated transcriptome, which potentially confers protection to vitiligo skin from an increased incidence of NMSC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Serum vasohibin‐1 levels: a potential marker of dermal and pulmonary fibrosis in systemic sclerosis

xlomafota13 shared this article with you from Inoreader Serum vasohibin‐1 levels: a potential marker of dermal and pulmonary fibrosis in systemic sclerosis Via Experimental Dermatology Abstract Vasohibin‐1 (VASH‐1) is a potent anti‐angiogenic factor mainly produced by endothelial cells. In addition, VASH‐1 prevents TGF‐β‐dependent activation of renal fibroblasts. Since systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrosis of multiple organs, VASH‐1 may be involved in the development of this disease. In this study, we investigated the potential role of VASH‐1 in SSc by evaluating the clinical correlation of serum VASH‐1 levels and the expression of VASH‐1 in SSc‐involved skin. Serum VASH‐1 levels were higher in SSc patients, especially those with diffuse cutaneous involvement, than in healthy controls and positively correlated with skin score. Furthermore, SSc patients with interstitial lung disease had significantly elevated levels of serum VASH‐1 as compared to those without. Importantly, serum VASH‐1 levels correlated inversely with both the percentage of predicted vital capacity and the percentage of predicted diffusion lung capacity for carbon monoxide and positively with serum KL‐6 levels, but not serum surfactant protein‐D levels. In SSc‐involved skin, VASH1 mRNA was remarkably upregulated compared with healthy control skin, but the major source of VASH‐1 was not clear. Fli1 deficiency, a predisposing factor inducing SSc‐like endothelial properties, did not affect VASH‐1 expression in human dermal microvascular endothelial cells. Collectively, these results suggest that VASH‐1 upregulation in the skin and sera is linked to dermal and pulmonary fibrotic changes in SSc, while the contribution of VASH‐1 to SSc vasculopathy seems to be limited. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Keratinocyte‐derived IL‐1β induces PPARG down‐regulation and PPARD up‐regulation in

xlomafota13 shared this article with you from Inoreader Keratinocyte‐derived IL‐1β induces PPARG down‐regulation and PPARD up‐regulation in Via Experimental Dermatology Abstract Peroxisome proliferator‐activated receptors (PPARs) are a family of nuclear hormone receptors. In skin, PPARs modulate inflammation, lipid synthesis, keratinocyte differentiation and proliferation and thus are important for skin barrier homeostasis. Accordingly, PPAR expression is altered in various skin conditions that entail epidermal barrier impairment i.e. atopic dermatitis (AD) and psoriasis. Using human epidermal equivalents (HEEs) we established models of acute epidermal barrier impairment devoid of immune cells. We assessed PPAR and cytokine expression after barrier perturbation and examined effects of keratinocyte‐derived cytokines on PPAR expression. We show that acetone or SDS treatment causes graded impairment of epidermal barrier function. Furthermore, we demonstrate that besides IL‐1β and TNFα, IL‐33 and TSLP are highly relevant markers for acute epidermal barrier impairment. Both SDS‐ and acetone‐mediated epidermal barrier impairment reduce PPARG expression levels, whereas only SDS enhances PPARD expression. In line with findings in IL‐1β and TNFα treated HEEs, abrogation of IL‐1 signaling restores PPARG expression and limits the increase of PPARD expression in SDS‐induced epidermal barrier impairment. Thus, following epidermal barrier perturbation, keratinocyte‐derived IL‐1β and partly TNFα modulate PPARG and PPARD expression. These results emphasize a role for PPARγ and PPARβ/δ in acute epidermal barrier impairment with possible implications for diseases such as AD and psoriasis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Head and neck cancer and non‐steroidal anti‐inflammatory drugs: Systematic review and meta‐analysis

xlomafota13 shared this article with you from Inoreader Head and neck cancer and non‐steroidal anti‐inflammatory drugs: Systematic review and meta‐analysis Via Head & Neck Abstract The objective was to assess the effects of non‐steroidal anti‐inflammatory drugs (NSAIDs) on head and neck cancer (HNC) outcomes. A systematic review was conducted following the PRISMA guidelines. The MEDLINE and the Cochrane Central Register databases were searched. Risk of bias was assessed by the Cochrane Collaboration's tool and by the Newcastle‐Ottawa Scale. Meta‐analyses were performed with the RevMan software. Seventeen articles met the inclusion criteria. Quality scores for observational studies ranged between 5 and 8 stars and the RCT was assessed as high risk of bias. NSAIDs use was associated with a 13% risk reduction of HNC (OR: 0.87 95% CI 0.77–0.99). NSAIDs use was associated with a 30% reduced cancer‐specific mortality and with a 40% decreased risk on disease‐recurrence. NSAIDs may have a modest protective effect on HNC risk and a positive impact on cancer‐specific survival and disease‐recurrence. The findings do not support a protective role of as pirin on HNC outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multi-Detector CT Instillation Dacryocystography and Its Role in the Diagnosis of Lacrimal Drainage System Blocks

xlomafota13 shared this article with you from Inoreader Multi-Detector CT Instillation Dacryocystography and Its Role in the Diagnosis of Lacrimal Drainage System Blocks Via Otolaryngology Indian Abstract To assess the use of Multi-detector computed tomography instillation dacryocystography (MDCT-DCG) and its role in the diagnosis of lacrimal drainage system (LDS) blocks. It is a prospective evaluation of Twenty-five cases presenting with symptoms with NLDO (nasolacrimal duct obstruction) assessed by MDCT-DCG. The study was conducted in LN medical college and JK hospital Bhopal (M.P) territory centre between January 2016 and January 2017. Various levels of LDS obstruction were detected, Lower canaliculus 12% common canaliculus in 20% patients, lacrimal sac in 12% junction between lacrimal sac and NLD in 40% and NLD obstruction in 16% patients. The most common CTDCG findings were dilated opacified lacrimal sac with no opacification of the nasolacrimal duct (NLD) in 40% patients. CTDCG is a non-invasive, quick, patient friendly, indispensable in the assessment of NLDO procedure that adds benefit in documentation and preoperative planning. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.