Αναζήτηση αυτού του ιστολογίου

Πέμπτη 10 Δεκεμβρίου 2020

Surgical management of the fourth ventricular tumors using telovelar approach

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Publication date: Available online 8 December 2020

Source: Clinical Neurology and Neurosurgery

Author(s): Ehsan Nazari Maloumeh, Reza Jalili Khoshnoud, Kaveh Ebrahimzadeh, Hesameddin Hoseini Tavassol, Sepideh Salari, Ali Mousavinejad, Atiye Kargari, Mohammad Samadian, Omidvar Rezaei

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FAM46A expression is elevated in glioblastoma and predicts poor prognosis of patients

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Publication date: Available online 8 December 2020

Source: Clinical Neurology and Neurosurgery

Author(s): Yibiao Wang, Renduan Cai, Pengcheng Wang, Chuixue Huang, Chaocai Zhang, Zhaohui Liu

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Delayed transhemispheric propagation of electrographic seizures following functional hemispherectomy

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Publication date: Available online 8 December 2020

Source: Clinical Neurology and Neurosurgery

Author(s): Oliver Phillips, Petya Radoeva, Luca Bartolini

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Early-Onset Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Diagnosed in Adulthood

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Publication date: Available online 8 December 2020

Source: Clinical Neurology and Neurosurgery

Author(s): Turgut Sahin, Fatma Tugra Karaarslan, Rezzak Yilmaz, Şeyma Tekgül, Ayşe Nazlı Başak, Muhittin Cenk Akbostanci

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Papillary Tumor of the Pineal Region in Pediatric Populations: An Additional Case and Systematic Review of a Rare Tumor Entity

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Publication date: Available online 8 December 2020

Source: Clinical Neurology and Neurosurgery

Author(s): Mansour Mathkour, Joshua Hanna, Naser Ibrahim, Tyler Scullen, Mitchell D. Kilgore, Cassidy Werner, Ian Cormier, Pierce Spencer, Joseph R. Keen, Cuong J. Bui

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Reconstruction of chronic scalp erosion after deep brain stimulation surgery

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To investigate the reconstructive effectiveness for chronic scalp erosion after deep brain stimulation (DBS).
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A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

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Condition:   Urinary Bladder Neoplasms
Interventions:   Drug: Cetrelimab;   Drug: TAR-200;   Drug: Cisplatin;   Drug: Gemcitabine;   Radiation: Conventional radiation therapy;   Radiation: Hypo-fractioned radiation therapy
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting
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Triamcinolone Levels in Cochlear Perilymph, Lateral Canal and CSF

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Condition:   Vestibular Schwannoma
Intervention:   Drug: Triamcinolone Acetonide 40mg/mL
Sponsor:   Medical University of Vienna
Recruiting
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The Effect of Non-resistance Technique for Neck Pain Due to a Whiplash Injury

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Condition:   Whiplash Injury of Cervical Spine
Interventions:   Other: non-resistance therapy;   Other: acupuncture;   Other: chuna;   Other: pharmacoacupuncture;   Drug: Korean herbal medicine
Sponsor:   Jaseng Medical Foundation
Recruiting
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Ramucirumab and Trifluridine/Tipiracil or Paclitaxel for the Treatment of Patients With Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer

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Conditions:   Clinical Stage III Gastric Cancer AJCC v8;   Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IV Gastric Cancer AJCC v8;   Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IVA Gastric Cancer AJCC v8;   Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IVB Gastric Cancer AJCC v8;   Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Locally Advanced Unresectable Gastric Adenocarcinoma;   Locally Advanced Unresectable Gastroesophageal Junction Adenocarcinoma;   Metastatic  Gastric Adenocarcinoma;   Metastatic Gastroesophageal Junction Adenocarcinoma;   Pathologic Stage III Gastric Cancer AJCC v8;   Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IIIA Gastric Cancer AJCC v8;   Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IIIB Gastric Cancer AJCC v8;   Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IIIC Gastric Cancer AJCC v8;   Pathologic Stage IV Gastric Cancer AJCC v8;   Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Postneoadjuvan t Therapy Stage III Gastric Cancer AJCC v8;   Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8;   Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
Interventions:   Drug: Paclitaxel;   Other: Quality-of-Life Assessment;   Biological: Ramucirumab;   Drug: Trifluridine and Tipiracil Hydrochloride
Sponsors:   Academic and Community Cancer Research United;   National Can cer Institute (NCI)
Not yet recruiting
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Study of Pharmacokinetic, Safety, Immunogenicity and Efficacy of CMAB819 and Nivolumab in R/M HNSCC

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Condition:   Squamous Cell Carcinoma of the Head and Neck
Interventions:   Drug: CMAB819;   Drug: Nivolumab
Sponsor:   Taizhou Mabtech Pharmaceutical Co.,Ltd
Recruiting
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Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics

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Recent studies have provided several insights into acute myeloid leukemia. Studies based on molecular biology have identified eight functional mutations involved in leukemogenesis, including driver and passenger mutations. Insight into Leukemia stem cells (LSCs) and assessment of cell surface markers have enabled characterization of LSCs from hematopoietic stem and progenitor cells. Clonal evolution has been described as having an effect similar to that of microenvironment alterations. Such biological findin gs have enabled the development of new targeted drugs, including drug inhibitors and monoclonal antibodies with blockage functions. Some recently approved targeted drugs have resulted in new therapeutic strategies that enhance standard intensive chemotherapy regimens as well as supportive care regimens. Besides the progress made in adoptive immunotherapy, since allogenic hematopoietic stem cell transplantation enabled the development of new T-cell transfer therapies, such as chimeric antigen receptor T-cell and transgenic TCR T-cell engineering, new promising strategies that are investigated.

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MR-Guided Radiotherapy for Prostate Cancer

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External beam radiotherapy remains the primary treatment modality for localized prostate cancer. The radiobiology of prostate carcinoma lends itself to hypofractionation, with recent studies showing good outcomes with shorter treatment schedules. However, the ability to accurately deliver hypofractionated treatment is limited by current image-guided techniques. Magnetic resonance imaging is the main diagnostic tool for localized prostate cancer and its use in the therapeutic setting offers anatomical informat ion to improve organ delineation. MR-guided radiotherapy, with daily re-planning, has shown early promise in the accurate delivery of radiotherapy. In this article, we discuss the shortcomings of current image-guidance strategies and the potential benefits and limitations of MR-guided treatment for prostate cancer. We also recount present experiences of MR-linac workflow and the opportunities afforded by this technology.

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