Occupational Health

A Comparison of Job Stress Models: Associations With Employee Well-Being, Absenteeism, Presenteeism, and Resulting Costs Objective: This study investigates the associations between Effort–Reward–Imbalance (ERI), Overcommitment (OC), Job–Demand–Control (JDC), and Organizational Injustice (OIJ) with employee well-being, absenteeism, and presenteeism, as well as the costs incurred. Methods: Cross-sectional data from 1440 German pharmaceutical company employees assessing job stress, employee well-being, absenteeism, and presenteeism were used. Linear regression and interval regression analyses assessed separate and independent associations and sample-specific costs were estimated. Results: All four stressors were related to employee well-being, presenteeism, and absenteeism when analyzed separately. OIJ showed the strongest independent association with absenteeism (coef. = 0.89; P < 0.01), whereas OC was most strongly independently associated with lower well-being (coef. = −0.44; P < 0.01) and higher presenteeism (coef. = 0.28; P < 0.01). Absenteeism costs per employee/year were higher than presenteeism costs. Conclusions: Occupational health interventions reducing job stress will have strong potential for productivity raise and lower costs.

A Cluster Randomized Controlled Trial to Evaluate HeadCoach: An Online Mental Health Training Program for Workplace Managers Objective: Mental ill-health is now the leading cause of sickness absence and occupational incapacity in high-income countries. This study evaluated HeadCoach online manager training, designed to improve confidence, and managerial behaviors that create mentally healthy workplaces. Methods: A cluster randomized controlled trial was conducted comparing managers who received HeadCoach (N = 87) to waitlist control (N = 123). Managers' confidence and behavior were investigated at baseline, postintervention, and follow-up. Psychological distress of direct reports was evaluated. Results: Confidence significantly increased postintervention only; however, per-protocol analyses indicated a significant improvement for program completers compared with control at both time points. Responsive and preventive behaviors significantly improved. Psychological distress of direct reports remained unchanged. Conclusions: HeadCoach online mental health training is an effective and scalable way to improve managers' confidence and workplace practices around mental health. The impact on direct reports remains unknown.

Agricultural Exposures and Breast Cancer Among Latina in the San Joaquin Valley of California Objective: The aim of this study was to assess the role of agricultural work, pesticide exposure, and age at first farm labor exposure in breast cancer (BC) risk among Hispanic women in Central California. Methods: A BC case control study was conducted. Latina BC cases were identified through the California Cancer Registry and controls were recruited. Both cases and controls completed a detailed questionnaire. Pesticide exposure data were obtained by linking the crops, work locations, and dates worked in specific farm jobs with the California Department of Pesticide Regulation (DPR) Pesticide Use Reports (PUR). Results: Chemicals associated with BC risk included organophosphates, organochlorines, and a phthalimide, Captan. Age at first work in farm labor was younger in cases than controls (P = 0.03). Conclusions: Agricultural work may be associated with the increased BC risk in female Hispanic farm workers.

Workplace Interventions can Reduce Sickness Absence for Persons With Work-Related Neck and Upper Extremity Disorders: A One-Year Prospective Cohort Study Objective: The objective of this study was to investigate whether workplace interventions are effective in reducing sickness absence in persons with work-related neck and upper extremity disorders and whether disorder improvement after intervention reduces sickness absence. Methods: This study was a prospective cohort study of workers with work-related neck pain or upper extremity disorders. Data were obtained from the Swedish "Work-related disorders" and "Work environment" surveys. Register data on sickness-absence 1 year after the surveys were made and obtained from the Swedish health insurance database. Results: A significant lower number of sickness-absence days were found for workers reporting improvement after intervention. Conclusion: The findings in this study suggest that workplace intervention can reduce sickness absence for workers with neck or upper extremity disorders only if the intervention improves the disorder. The interventions were most effective in reducing medium long sickness absence periods.

Respiratory Health Among Hand Pickers in Primary Coffee-Processing Factories of Ethiopia Objective: The aim of this study was to assess chronic respiratory symptoms and lung function among female hand pickers. Methods: A total of 374 hand pickers exposed to coffee dust and 175 female controls from water bottling factories were included. The symptoms were assessed using a standardized questionnaire. Personal total dust exposure and lung function tests were performed. Results: Hand pickers experienced a higher dust exposure, displayed a higher prevalence ratio for cough [prevalence ratio (PR) = 3.0, 95% confidence interval (95% CI): 1.4 to 6.2] and work-related shortness of breath (PR = 2.5, 95% CI: 1.1 to 5.6), and had a lower FEF25–75 than controls. Hand pickers without tables had a significantly higher prevalence ratio of cough with sputum (PR = 3.9, 95% CI: 1.6 to 9.5) and lower forced vital capacity, forced expiratory volume in 1 second, and mean forced expiratory flow between 25% and 75% of the FVC than hand pickers with tables. Conclusion: Hand pickers show a range of adverse symptoms and lung function impairments that warrant efforts to improve working conditions.

Occupational Violence and PTSD-Symptoms: A Prospective Study on the Indirect Effects of Violence Through Time Pressure and Nontraumatic Strains in the Occupational Context Objective: The aim of this study was to assess whether frequency of occupational violence (OV) affects posttraumatic stress disorder (PTSD) symptoms through nontraumatic strains in the occupational context. Methods: Twelve-month prospective survey data on 1763 Social educators were used. Path-analysis measured direct and indirect pathways of frequency of OV on PTSD through change in time pressure, change in burnout, change in sense of safety at work, and change in coping with regret in patient work. Results: Forty-two pct. of the variance in PTSD symptoms was predicted; F (20, 1541) = 36.8, P < 0.001, R2 = 0.42. Frequency of OV indirectly affected level of PTSD through all the mediators; estimated indirect effects = 0.14, 95% confidence interval 0.07 to 0.22. Conclusion: PTSD resulting from OV is not only a result of the violent acts themselves but is also caused by nontraumatic strains. It is essential to include the broader context of work environment factors in prevention of work-related PTSD.

Work Exposures and Musculoskeletal Disorders Among Railroad Maintenance-of-Way Workers Objective: The aim of this study was to measure musculoskeletal disorders and occupational risk factors among railroad maintenance-of-way (MOW) workers. Methods: Four thousand eight hundred sixteen active, retired, and disabled members of the Brotherhood of Maintenance of Way Employes Division (BMWED) completed a survey. Results: Compared with U.S. employed men, adjusting for age, race, and region, active male MOW workers were more likely to report "repeated lifting, pushing, pulling, or bending" at work (74.6% vs 46.9%), not enough staff (88.1% vs 65.2%), and a diagnosis of carpal tunnel syndrome (7.9% vs 3.6%). They were less likely to report management priority on workplace health and safety (59.37% vs 94.8%), ability to make job decisions on their own (68.4% vs 87.7%), and supervisor support (60.3% vs 90.8%) (all comparisons, P < 0.001). Conclusion: Prevention programs should address risk of musculoskeletal disorders and occupational hazards faced by MOW workers.

Health Risk Calculator: An Online, Interactive Tool to Estimate how Health Impacts Workers' Compensation Claim Incidence and Cost Objective: The purpose of this paper is to describe and evaluate a web-based, educational Health Risk Calculator that communicates the value of investing in employee health and well-being for the prevention of work-related injuries, illnesses, and fatalities. Methods: We developed and evaluated the calculator following the RE-AIM framework. We assessed effectiveness via focus groups (n = 15) and a post-use survey (n = 33) and reach via website analytics. Results: We observed evidence for the calculator's usability, educational benefit, and encouragement of action to improve worker health and safety. Website analytics data demonstrated that we reached over 300 users equally in urban and rural areas within 3 months after launch. Conclusion: We urge researchers to consider the ways in which they can communicate their empirical research findings to their key stakeholders and to evaluate their communication efforts.

Assessment of Objective Symptoms of Depression in Occupational Health Examination Objective: The aim of the study was to assess early symptoms of depression in regular occupational health examination using the objective measures based on electroencephalographic (EEG) signal analysis. Methods: The study was performed on 125 volunteer participants. The resting-state EEG signal was recorded for 7 minutes. The spectral asymmetry index (SASI) and Higuchi fractal dimension (HFD) were calculated in EEG channel Pz. Parallel, the participants were subjected to two psychological tests, observer-rated HAM-D and self-rated EST-Q-D. Results: The SASI revealed depressive symptoms for 64.8%, HFD for 55.2%, HAM-D for 44.8%, and EST-Q-D for 28.8% of participants. Combination of two different measures indicated depression symptoms up to 78.4% of participants. Conclusion: The results of this study confirm the feasibility of indication of early symptoms of depression applying EEG-based objective measures.

Sex Differences in Gulf War Illness: A Reanalysis of Data From the CDC Air Force Study Using CDC and Modified Kansas Case Definitions Objective: Estimate and compare the prevalence of Gulf War Illness (GWI) in male and female Gulf War veterans using Centers for Disease Control and Prevention (CDC) and modified Kansas case definitions. Methods: Data from the landmark CDC Air Force Study of GW Air Force veterans is used. Results: Nearly half of the deployed veterans met the GWI CDC case definition compared with 14% of non-deployed veterans. Only 29% met the definition using the modified Kansas criteria compared with 8% of non-deployed veterans. Deployed veterans and female veterans exhibited significantly higher GWI risk. Female GW veterans had higher rates of severe and mild-to-moderate cases of GWI. Conclusion: Results suggest increased GWI rates based on CDC and modified Kansas criteria among deployed and female veterans. Further research is needed to examine the chronic health outcomes of female GW veterans independently.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Occupational and Environmental Medicine

Issue Highlights No abstract available

Answering the question: Is the Doctor of Philosophy or Doctor of Nursing Practice right for me? Over the past decade, leading health care organizations have recommended doubling the number of doctorally prepared nurses to meet the future demands of health care. In 2018, the National Organization of Nurse Practitioner Faculties committed to move all nurse practitioner degree programs to the Doctor of Nursing Practice degree by 2025. As more and more doctorally prepared nurses enter the workforce, other nurses are considering returning to school for a terminal degree. This column will review options for doctoral education in nursing and the strength, focus, and program requirements for PhD and DNP degrees.

Pharmacogenomics in clinical care Health care designed specifically for a person based on their genetic makeup ("personalized" or "precision" medicine) is expanding rapidly, especially in the area of drug selection. Pharmacogenomic (PGx) testing, when drugs and doses are selected based on an individual's genetic profile, is increasingly being used to guide the selection of drugs or therapies to optimize outcomes and minimize side effects. Based on an individual's genetic blueprint, health care providers now have important information about how a drug is likely to behave in that individual's body. Pharmacogenomic information on drug labels is now available for nearly 250 drugs. Health care organizations are also increasingly making this information available to customers to reduce emergency department visits, improve outcomes (selecting the right chemotherapy doses), and reduce cost. This study reviews some of the challenges and benefits on using PGx testing to improve clinical outcomes.

Research translation and the evolving PhD and DNP practice roles: A collaborative call for nurse practitioners Doctoral prepared nurse practitioners (NPs) are uniquely positioned for responsible leadership as essential members of the health care system and have a professional responsibility to contribute to research and clinical inquiry initiatives that advance health care delivery and improve outcomes. Academic preparation of the Doctor of Philosophy (PhD) and Doctor of Nursing Practice (DNP), although different in focus, offers opportunities for effective collaborations that transcend and integrate the scientific and practice roles of generating data and translating evidence. As health care organizations evolve in managing complexities of providing high-quality care, roles for the PhD as research scientist and DNP as research translation specialist will also evolve to keep pace. Despite this professional calling and global opportunity for research and evidence-based practice (EBP), future NPs and nurses will be challenged with an imminent lack of experts who have the skills needed for data and research generation and evidence translation. This commentary introduces and discusses emerging roles and organizational models for doctoral prepared NPs in research, EBP, quality assurance, and quality improvement projects, offers suggestions for NPs interested in research and clinical inquiry, and seeks to ignite excitement for scientific discovery in NP-driven initiatives. Nurse practitioners are encouraged to take advantage of the many opportunities to shape and expand their careers by engaging in knowledge generation for improving health care outcomes.

From education to practice: What we can learn about the workforce from a survey of new nurse practitioners Background and purpose: To understand the posttraining plans and job market for new nurse practitioners (NPs), a survey was conducted of new family NPs (FNPs) in 2017. The survey was also designed to test the logistics and feasibility of conducting such a survey on a national scale and the usefulness of data gathered. Methods: A descriptive, cross-sectional study was conducted through an online survey administered to a national sample of 159 FNPs who graduated from an accredited NP program. Conclusions: Many new NPs are not willing or interested in moving out of their local community even if there are limited opportunities locally. There are high numbers of NPs going into private practice compared with community health or federally qualified health centers. Many new NPs have extensive previous work experience as registered nurses in hospitals; the career progression to NP shifts their work setting from inpatient to outpatient settings. Implications for practice: Although the job market for new NPs is generally good, with the rapid increase in NP graduates combined with the unwillingness or inability of many new NPs to move, some areas may have surpluses of NPs and limited job opportunities for new NPs, whereas other areas may have shortages upcoming. The survey of new NP graduates is a useful tool to monitor the experience of new NPs and provides valuable information to NP programs and prospective students. Future research should ensure a representative sample of new graduate NPs to accurately reflect the experience of new NPs.

Tax incentives for preceptors of nurse practitioner students in Massachusetts: A potential solution With a growing population, there is an increasing need for nurse practitioners to improve access to health care. There is currently a shortage of nurse practitioner (NP) preceptors across Massachusetts, making clinical placements difficult and at times unachievable. The lack of NP preceptors has a direct impact on student outcomes, educational programs, and ultimately access to care. The authors explored lessons learned about the national scale of this problem and whether Massachusetts should entertain legislative initiatives similar to other states as a solution. Data were collected from the boards of nursing and the national and state chapters of the American Association of Nurse Practitioners regarding current and pending legislation. State and federal sources and the Massachusetts Association of Colleges of Nursing provided statistical and qualitative data on current and future needs for NP preceptors. States that have successfully passed legislation have awarded tax incentives to NP preceptors, although none of the existing regulations have assessed for their effectiveness in improving preceptor availability. Massachusetts may benefit from legislation to improve NP student access to preceptors; however, incentives related to geographical location may best serve both students and the greater population.

Understanding nurse practitioner scope of practice: Regulatory, practice, and employment perspectives now and for the future The nurse practitioner (NP) role has existed for 50 years. During the past 10 years, a national effort to use NPs to the full extent of their education based on the 2008 Consensus Model for Advanced Practice Registered Nurse Regulation and the 2010 Institute of Medicine Report on the Future of Nursing continues to result in variable scopes of practice (SOP) between states. Subsequently, NPs have a lack of clarity on SOP because it relates to population foci and practice setting. Review and analysis of state-based statutes and rules with the current literature focused on NP SOP, including documents by the National Council of State Boards of Nursing, was conducted. Clarification and understanding of SOP is essential for safe practice and optimum access to care. Inconsistent SOP regulation continues to exist between states, and NPs can be in employment situations that place them in a position to possibly breech their SOP. Although practice is not setting specific, NP licensure is based on NP education and certification that is competency based within population foci, and credentialing by employers should align with these parameters. Continuing to work toward a more common NP SOP between states and achievement of full practice authority means periodic reassessment of NP education and practice models. Practice mobility is essential for continued advancement of the NP profession and increased access to care by the public.

Understanding nurse practitioner scope of practice: Regulatory, practice and employment perspectives now and for the future general No abstract available

Improving outcomes through care coordination: Measuring care coordination of nurse practitioners Background: Gaps in care coordination (CC) between inpatient and outpatient settings for children with medical complexity (CMC) can result in treatment delays, gaps in communication, missed appointments, medication discrepancies, and ultimately impacts the provision of quality care. Local problem: As care for pediatric patients with medical complexity moves into community settings, various ambulatory settings, including infusion settings, are caring for patients who would otherwise often require inpatient hospitalization to receive their care. To better accommodate this growing demand, nurse practitioners (NPs) have been used to support these nurse-led infusion programs. The purpose of this quality improvement (QI) project was to quantify and describe the outcomes of CC by NPs in this ambulatory setting. Methods: A quantitative design was used. Interventions: We captured nonreimbursable CC activities provided by NPs and associated outcome(s) among pediatric patients seen in two ambulatory infusion clinics, at Boston Children's Hospital between January and April 2017, and generated summary statistics for this QI project. Results: There were 259 nonreimbursable CC encounters. Most of the CC activities prevented delays in treatment (38%), adverse reaction to medicine because of medication discrepancies (8%), need for additional subspecialist visits (10%), missed infusion appointments (5%), and emergency department visits (2%). Conclusion: Nonreimbursable CC provided by NPs in a tertiary hospital-based ambulatory program improved outcomes of care for CMC and helped facilitate health care use. This project quantified and described the outcomes of CC provided by NPs, and the value of CC on CMC.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Experimental and Therapeutic Medicine

Association between CIRP expression and hypoxic‑ischemic brain injury in neonatal rats Lifang Chen, Qiaohuan Tian, Weihua Wang View Abstract ❯
Combined dynamic spectral imaging and routine colposcopy strategy for the diagnosis of pre‑cancerous cervical lesions Dan Liu, Wanliang Hu View Abstract ❯
Danon disease: Two patients with atrial fibrillation in a single family and review of the literature Shaohua Guo, Linghuan Zhou, Renping Wang, Zhixin Lv, Hongzun Xu, Baoli Han, Panagiotis Korantzopoulos, Fuli Hu, Tong Liu View Abstract ❯
Clinical significance of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in acute cerebral hemorrhage with gastrointestinal hemorrhage, and logistic regression analysis of risk factors Yu Zou, Wei Zhang, Chuanjun Huang, Yangqing Zhu View Abstract ❯
Efficacy of continuous intravenous pumping of insulin for patients with diabetes complicated with perianal abscess and the effect on inflammatory cytokines Zhifeng Zhong, Huaying Huang, Yuejun Han, Wuzhen Dong View Abstract ❯
Effects of Achyranthes bidentata alcohol on proliferation capacity of osteoblasts and miRNA in Runx2 Shan Hua, Xuexue Zhang View Abstract ❯
Probiotic effect on Helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells Hanyi Song, Long Zhou, Dongyan Liu, Lihui Ge, Yan Li View Abstract ❯
Methylation‑regulated ZNF545 inhibits growth of the p53‑mutant KYSE150 cell line by inducing p21 and Bax Yu Fan, Yu Wang, Shaozhi Fu, Duan Liu, Sheng Lin View Abstract ❯
Eldecalcitol, an active vitamin D analog, effectively prevents cyclophosphamide‑induced osteoporosis in rats Wei Wang, Yuan Gao, Hongrui Liu, Wei Feng, Xiaoyan Li, Jie Guo, Minqi Li View Abstract ❯
LINK‑A lncRNA participates in the pathogenesis of glioma by interacting with survivin Xia Hua, Guangxing Li, Zhongtao Liu, Zhanfeng Niu View Abstract ❯
Mechanical loading mediates human nucleus pulposus cell viability and extracellular matrix metabolism by activating of NF‑κB Kai Zhang, Chao Xue, Ning Lu, Peng Ren, Haiwen Peng, Yao Wang, Yan Wang View Abstract ❯
Diagnostic value of echocardiography in fetal cardiac malformation and clinical classification Bo Wang, Jianning Li, Juan Yin View Abstract ❯
A seven‑miRNA expression‑based prognostic signature and its corresponding potential competing endogenous RNA network in early pancreatic cancer Xue Bai, Donglan Lu, Yan Lin, Yufeng Lv, Liusheng He View Abstract ❯
Renal impact of high‑loading‑dose statin pre‑cardiac catheterization in patients with chronic kidney disease and long‑term statin use Chang Hou, Bo Zheng, Xin‑Gang Wang, Bin Zhang, Qiu‑Ping Shi, Ming Chen View Abstract ❯
Protective effect of rivaroxaban on arteriosclerosis obliterans in rats through modulation of the toll‑like receptor 4/NF‑κB signaling pathway Xinjiang Lou, Zhi Yu, Xiaoxia Yang, Jie Chen View Abstract ❯
MALAT1 overexpression promotes the proliferation of human periodontal ligament stem cells by upregulating fibroblast growth factor 2 Pei Chen, Yanhong Huang, Yarong Wang, Shaobing Li, Hongxing Chu, Mingdeng Rong View Abstract ❯
Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy Yang Zhang, Rongfang Zhang, Nannan Ding View Abstract ❯
Effects of ivabradine hydrochloride combined with trimetazidine on myocardial fibrosis in rats with chronic heart failure Dongwen Ma, Tong Xu, Guoqiang Cai, Xilin Wu, Zhendong Lei, Xinmei Liu, Junying Li, Ning Yang View Abstract ❯
miR‑125a‑5p inhibits the expression of NLRP3 by targeting CCL4 in human vascular smooth muscle cells treated with ox‑LDL Jiawang Wang, Qiong Wu, Jing Yu, Xufen Cao, Zesheng Xu View Abstract ❯
Downregulation of miR‑3934‑5p enhances A549 cell sensitivity to cisplatin by targeting TP53INP1 Aijun Ren, Zhenzhen Wen, Liangjie Zheng View Abstract ❯
A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis Violeta‑Claudia Bojincă, Claudiu C. Popescu, Raluca‑Daniela Decianu, Andrei Dobrescu, Șerban Mihai Bălănescu, Andra‑Rodica Bălănescu, Mihai Bojincă View Abstract ❯
Enhanced autophagy alleviates injury during hindlimb ischemia/reperfusion in mice Chenshu Liu, Meixiu Peng, Liang Zheng, Yang Zhao, Rui Wang, Qiao Su, Sifan Chen, Zilun Li View Abstract ❯
7,8‑Dihydroxyflavone activates Nrf2/HO‑1 signaling pathways and protects against osteoarthritis Dawei Cai, Wan Feng, Jun Liu, Longhai Jiang, Sichun Chen, Tangbo Yuan, Chen Yu, Hao Xie, Dawei Geng, Jian Qin View Abstract ❯
Expression of apolipoprotein M and its association with adiponectin in an obese mouse model Liu Yang, Tie Li, Shuiping Zhao, Saidan Zhang View Abstract ❯
Peripheral immune cell markers in children with recurrent respiratory infections in the absence of primary immunodeficiency Adriana Narcisa Munteanu, Mihaela Surcel, Radu‑Ionuț Huică, Gheorghița Isvoranu, Carolina Constantin, Ioana Ruxandra Pîrvu, Carmen Chifiriuc, Coriolan Ulmeanu, Cornel Ursaciuc, Monica Neagu View Abstract ❯
Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non‑obese type 2 diabetic Goto‑Kakizaki rats Jantira Sanit, Eakkapote Prompunt, Punyanuch Adulyaritthikul, Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Kantapich Kongpol, Anusak Kijtawornrat, Soontaree Petchdee, Stephanie Barrère‑Lemaire, Sarawut Kumphune View Abstract ❯
Causes of and treatment options for dislocation following total hip arthroplasty (Review) Yian Lu, Haijun Xiao, Feng Xue View Abstract ❯
Gestational weight management and pregnancy outcomes among women of advanced maternal age Juan Lin, Yuelin Fu, Qing Han, Jianying Yan, Rongxin Chen, Huale Zhang View Abstract ❯
Reduction of miR-29a-3p induced cardiac ischemia reperfusion injury in mice via targeting Bax Liang Zhang, Jian Zhang, Qiguang Tong, Guannan Wang, Hongling Dong, Zhonglu Wang, Qi Sun, Hangyu Wu View Abstract ❯
Metachromatic leukodystrophy: Characterization of two (p.Leu433Val, p.Gly449Arg) arylsulfatase A mutations Yangyang Wang, Xiang Chen, Chan Liu, Shamin Wu, Qingfeng Xie, Quan Hu, Shan Chen, Yiwei Liu View Abstract ❯
Anti‑inflammatory and anti‑apoptosis activity of taraxasterol in ulcerative colitis in vitro and in vivo Lu Che, Ya Li, Ruifeng Song, Cuihong Qin, Weiwei Hao, Bingxue Wang, Lei Yang, Puji Peng, Feng Xu View Abstract ❯
Effect of heme oxygenase 1 and renin/prorenin receptor on oxidized low‑density lipoprotein‑induced human umbilical vein endothelial cells Xin Gong, Congyang Liu, Hongling Wang, Jinying Fan, Cuihong Jiang, Yong Zou View Abstract ❯
Association of pregnancy‑associated plasma protein A and vascular endothelial growth factor with pregnancy‑induced hypertension Zhengzheng Zhang, Hao Xu, Xiao Liu, Pan Li, Wensheng Du, Qiuyu Han View Abstract ❯
Function and mechanism of pyrin and IL‑10 in the regulation of the inflammasome in pulmonary vascular endothelial cells following hemorrhagic shock Xin Jin, Yongxing Yao, Xing Lu, Peng Xu, Yanfei Xia, Shengmei Zhu View Abstract ❯
Comparison of dexmedetomidine with propofol as sedatives for pediatric patients undergoing magnetic resonance imaging: A meta‑analysis of randomized controlled trials with trial sequential analysis Yong Tang, Juan Meng, Xinxian Zhang, Jiong Li, Qiang Zhou View Abstract ❯
Population pharmacokinetic analysis of linezolid in patients with different types of shock: Effect of platelet count Dongdong Wang, Xiaofei Zheng, Yang Yang, Xiao Chen View Abstract ❯
Cadmium induces A549 cell migration and invasion by activating ERK Huijuan Zhai, Teng Pan, Haiyan Yang, Haiyu Wang, Yadong Wang View Abstract ❯
Effect of pidotimod combined with azithromycin on children with mycoplasma pneumonia and the expression levels of IL-10 and G-CSF in serum Hongxing Shi, Limin Lan, Xianghong Lv, Lizhi Sun View Abstract ❯
Effects of thyroid diseases on pregnancy outcomes Min Zhou, Min Wang, Juming Li, Xiaohui Luo, Minxiang Lei View Abstract ❯
Investigation into the expression levels of MAGEA6 in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues Jun Hao, Shuying Li, Jintao Li, Zhu Jiang, Maliha Ghaffar, Minglian Wang, Runqing Jia, Su Chen, Yangjunqi Wang, Yi Zeng View Abstract ❯
Gefitinib suppresses cervical cancer progression by inhibiting cell cycle progression and epithelial‑mesenchymal transition Jianyun Zheng, Jianxin Yu, Min Yang, Li Tang View Abstract ❯
lncRNA SCAL1 inhibits inducible nitric oxide synthase in lung cells under high‑glucose conditions Ping Li, Ning Zhang, Fen Ping, Yanfeng Gao, Lei Cao View Abstract ❯
Bioinformatics identification of potential genes and pathways in preeclampsia based on functional gene set enrichment analyses Xue Li, Yanning Fang View Abstract ❯
Effect of saphenous vein diameter and reflux time on stump length after cyanoacrylate closure Jeongin Kim, Jin Hyun Joh, Ho‑Chul Park View Abstract ❯
Immune promotive effect of bioactive peptides may be mediated by regulating the expression of SOCS1/miR‑155 Caixia Chen, Xiulan Su, Zhiwei Hu View Abstract ❯
Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway Xiaoyu Li, Qinghuai Li, Xiao Jin, Hao Guo, Yong Li View Abstract ❯
Smartphone‑assisted endoscopic surgery via Kocher's point for intraventricular hemorrhage caused by thalamic hemorrhage: A comparison with external ventricular drainage Xin Ge, Xinhua Xu, Xinguang Yu, Xiaolei Chen, Duo Li, Yanhua Xu, Yue Zhang View Abstract ❯
MicroRNA‑6852 suppresses glioma A172 cell proliferation and invasion by targeting LEF1 Jialiang Wang, Haipeng Liu, Kebin Zheng, Shuai Zhang, Wei Dong View Abstract ❯
Notch‑1 inhibition reduces proliferation and promotes osteogenic differentiation of bone marrow mesenchymal stem cells Ying He, Lijin Zou View Abstract ❯
Association between abdominal obesity and liver steatosis and fibrosis among patients with chronic hepatitis B measured by Fibroscan Jing Sun, Yanfang Li, Xuying Sun, Youde Liu, Danxia Zheng, Lijuan Fan View Abstract ❯
Isopsoralen ameliorates H2O2‑induced damage in osteoblasts via activating the Wnt/β‑catenin pathway Yu‑Peng Li, Bin Wu, Jie Liang, Fei Li View Abstract ❯
miR‑448 promotes progression of non‑small‑cell lung cancer via targeting SIRT1 Hongfeng Qi, Haifeng Wang, Dabin Pang View Abstract ❯
Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells Jae Young Shin, Denis Nchang Che, Byoung Ok Cho, Hyun Ju Kang, Jisu Kim, Seon Il Jang View Abstract ❯
Wnt3a downregulates thyroid hormone‑induced osteocalcin expression in osteoblasts Kazuhiko Fujita, Takanobu Otsuka, Tetsu Kawabata, Go Sakai, Woo Kim, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda View Abstract ❯
Role and effective therapeutic target of gut microbiota in NAFLD/NASH (Review) Qun Liu, Shousheng Liu, Lizhen Chen, Zhenzhen Zhao, Shuixian Du, Quanjiang Dong, Yongning Xin, Shiying Xuan View Abstract ❯
Clinical characteristics and phenotype distribution in 10 Chinese patients with X‑linked adrenoleukodystrophy Ming‑Rui Jia, Wen‑Zhen Wu, Chuan‑Ming Li, Xiao‑Hui Cai, Lin Zhang, Fang Yan, Chan Zhu, Ming‑Hong Gu View Abstract ❯
Acute remote ischemic preconditioning alleviates free radical injury and inflammatory response in cerebral ischemia/reperfusion rats Xian‑Liang Meng, Dong‑Lin Zhang, Shi‑Hua Sui View Abstract ❯
TLR4 gene in the regulation of periodontitis and its molecular mechanism Weijuan Qi, Xi Yang, Ning Ye, Shujun Li, Qianqian Han, Jinyu Huang, Buling Wu View Abstract ❯
Aberrant expression of long non‑coding RNAs in peripheral blood mononuclear cells isolated from patients with gouty arthritis Xiaowu Zhong, Yuanhong Peng, Hebin Liao, Chengjiao Yao, Jiulong Li, Qibin Yang, Yonglong He, Yufeng Qing, Xiaolan Guo, Jingguo Zhou View Abstract ❯
COL6A1 knockdown suppresses cell proliferation and migration in human aortic vascular smooth muscle cells Zongxiang Chen, Qingjian Wu, Chengjun Yan, Juan Du View Abstract ❯
Protective role of thymoquinone in sepsis‑induced liver injury in BALB/c mice Fei Wang, Xiong Lei, Yue Zhao, Qinggong Yu, Qianwei Li, Hui Zhao, Zuowei Pei View Abstract ❯
Blue laser magnifying endoscopy in the diagnosis of chronic gastritis Ying Zhu, Fang Wang, Yan Zhou, Gui‑Li Xia, Ling Dong, Wen‑Hua He, Bing Xiao View Abstract ❯
Identification of potential agents for thymoma by integrated analyses of differentially expressed tumour‑associated genes and molecular docking experiments Xiao‑Dong Wang, Peng Lin, Yu‑Xin Li, Gang Chen, Hong Yang, Yun He, Qing Li, Ruo‑Chuan Liu View Abstract ❯
Sodium ferulate attenuates high‑glucose‑induced oxidative injury in HT22 hippocampal cells Jiangpei Zhao, Lerong Liu, Lingxiao Zhang, Jing Lv, Xueli Guo, Xia Li, Tongfeng Zhao View Abstract ❯
The effect of bone marrow mesenchymal stem cell and nano‑hydroxyapatite/collagen I/poly‑L‑lactic acid scaffold implantation on the treatment of avascular necrosis of the femoral head in rabbits Le Wang, Leixin Xu, Changliang Peng, Guoxin Teng, Yu Wang, Xiaoshuai Xie, Dongjin Wu View Abstract ❯
PC‑1 NF suppresses high glucose‑stimulated inflammation and extracellular matrix accumulation in glomerular mesangial cells via the Wnt/β‑catenin signaling Liangxiang Xiao, Yingying Chen, Yang Yuan, Bo Xu, Qing Gao, Ping Chen, Tianying Zhang, Tianjun Guan View Abstract ❯
Oxygen‑induced circRNA profiles and coregulatory networks in a retinopathy of prematurity mouse model Huiting Zhou, Huihui Song, Yi Wu, Xiang Liu, Jing Li, He Zhao, Miaomiao Tang, Xiaoyuan Ji, Lu Zhang, Yuanyuan Su, Yao He, Kehong Feng, Yang Jiao, Hua Xu View Abstract ❯
Rapid progression and recovery of massive gastric mucosal damage complicated by Henoch‑Schönlein purpura in a patient with liver cirrhosis: A case report Tae‑Geun Gweon, Jung Hyun Kwon View Abstract ❯
Retrospective follow-up analysis of the transcriptomic patterns of cytokines, cytokine receptors and chemokines at preconception and during pregnancy, in women with post-partum depression Maria Cristina Petralia, Emanuela Mazzon, Paolo Fagone, Luca Falzone, Placido Bramanti, Ferdinando Nicoletti, Maria Sofia Basile View Abstract ❯
Altered spontaneous brain activity patterns in patients with retinal vein occlusion indicated by the amplitude of low‑frequency fluctuation: A functional magnetic resonance imaging study Yuan‑Yuan Wu, Qing Yuan, Biao Li, Qi Lin, Pei‑Wen Zhu, You‑Lan Min, Wen‑Qing Shi, Yong‑Qiang Shu, Qiong Zhou, Yi Shao View Abstract ❯
Comparison of endovascular treatment for middle cerebral artery aneurysm with a low‑profile visualized intraluminal support stent or pipeline embolization device Peng Lu, Ye Zhang, Huanjiang Niu, Yirong Wang View Abstract ❯
Calcitonin protects rat chondrocytes from IL‑1β injury via the Wnt/β‑catenin pathway Mingxiao Bai, Lei Ge, Hui Chen, Qunhua Jin View Abstract ❯
Effect of metformin on the proliferation, apoptosis, invasion and autophagy of ovarian cancer cells Ge Zou, Jie Bai, Dandan Li, Yan Chen View Abstract ❯
The effect of an alternative chromosome 17 probe on fluorescence in situ hybridization for the assessment of HER2 amplification in invasive breast cancer Zhigao Xu, Peipei Xu, Wei Fan, Ben Huang, Qingyuan Cheng, Zheng Zhang, Ping Wang, Mingxia Yu View Abstract ❯
Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits Kefei Chen, Feihu Dai, Guangxu Li, Jirong Dong, Yuhai Wang View Abstract ❯
Eldecalcitol effects on osteoblastic differentiation and function in the presence or absence of osteoclastic bone resorption Jie Bu, Juan Du, Lina Shi, Wei Feng, Wei Wang, Jie Guo, Tomoka Hasegawa, Hongrui Liu, Xuxia Wang, Minqi Li View Abstract ❯
Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis Xiuzhen Ma, Junfeng Deng, Xinmu Cui, Qi Chen, Weihua Wang View Abstract ❯
Expression of β‑catenin and MMP‑8 in gingival crevicular fluid and gingival tissue indicates the disease severity of patients with chronic periodontitis Lilei Zhu, Yao Yao, Jian Liu, Jingyu Wang, Hui Xie View Abstract ❯
Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival Miao Zhang, Xintong Lv, Yuanjun Jiang, Guang Li, Qiao Qiao View Abstract ❯
Expression and role of CaMKII and Cx43 in a rat model of post‑stroke depression Shuiliang Tao, Mengmeng Jia, Tao Qiu View Abstract ❯
Isoimperatorin enhances 3T3‑L1 preadipocyte differentiation by regulating PPARγ and C/EBPα through the Akt signaling pathway Tiantuan Jiang, Xiaochen Shi, Zunqiang Yan, Xin Wang, Shuangbao Gun View Abstract ❯
Characterization and identification of human immortalized granulosa cells derived from ovarian follicular fluid Ai Ai, Zhengya Tang, Yali Liu, Sha Yu, Bin Li, He Huang, Xiangsheng Wang, Yilin Cao, Wenjie Zhang View Abstract ❯
Oral administration of Urtica macrorrhiza Hand.‑Mazz. polysaccharides to protect against cyclophosphamide‑induced intestinal immunosuppression Zhongjuan Wang, Yanhua Li, Chongjing Wang, Hongying Xia, Yueqin Liang, Zhongkun Li View Abstract ❯
Analysis of Treg/Th17 cells in patients with tongue squamous cell carcinoma Changfu Liu, Zhou Tong, Jingyu Tan, Zengxi Xin View Abstract ❯
Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy Hongwei Wu, Gang Liu, Xia Yang, Qing Liu, Zhenguang Li View Abstract ❯
Long non‑coding RNA NEAT1 modulates hypoxia/reoxygenation‑induced cardiomyocyte injury via targeting microRNA‑520a Hua‑Jun Wu, Guan‑Min Tang, Ping‑Yang Shao, Hong‑Xing Zou, Wei‑Feng Shen, Ming‑De Huang, Hang‑Hai Pan, Chang‑Lin Zhai, Gang Qian View Abstract ❯
Effect of sepsis on the action potential and cardiac serotonin response in rats Zheng-Jiang Liu, Hua Liu, Changdong Wu, Kedong Xue View Abstract ❯
Cardiac resynchronization therapy coronary venous left ventricular lead removal and reimplantation: Experience from a single center in China Wencheng Zheng, Ding Li, Xuebin Li, Feng Ze, Long Wang, Jiangbo Duan, Cuizhen Yuan View Abstract ❯
Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer Xiangyu Meng, Yan Zhao, Jingwei Liu, Lu Wang, Zhe Dong, Tao Zhang, Xiaohu Gu, Zhichao Zheng View Abstract ❯
Upregulation of suppressor of cytokine signaling 3 ameliorates spinal degenerative disease in adolescents by mediating leptin and tumor necrosis factor‑α levels Xiao‑Ming Tang, Jian Dai, Hai‑Lang Sun View Abstract ❯
Ventricular tachycardia and heart failure in a patient of mid‑ventricular obstructive hypertrophic cardiomyopathy with apical aneurysm: A case report Xin Zhang, Xingbin Liu View Abstract ❯
Irreversible electroporation ablation of end‑stage metastatic retroperitoneal lesions: Report on three cases and literature review Tian'an Jiang, Qiyu Zhao, Guo Tian, Xinhua Chen, Liming Wu View Abstract ❯
Correlation between the tuberculin skin test and T‑SPOT.TB in patients with suspected tuberculosis infection: A pilot study Jing Yang, Weiliang Kong, Ning Xv, Xiaoping Huang, Xueqing Chen View Abstract ❯
A novel mutation of FOXC1 in a Chinese family with Axenfeld‑Rieger syndrome Xing Wu, Hai‑Nan Xie, Tong Wu, Wei Liu, Lan‑Lam Chen, Zhao‑Hui Li, Da‑Jiang Wang, Yi Wang, Hou‑Bin Huang View Abstract ❯
Supplementation of triple viable probiotics combined with dietary intervention is associated with gut microbial improvement in humans on a high‑fat diet Leimin Qian, Renyuan Gao, Jianming Huang, Huanlong Qin View Abstract ❯
Acute cytomegalovirus infection in an immunocompetent patient with ulcerative colitis: A case report Toshihide Maeda, Hiroyasu Sakai, Noritaka Ozawa, Tomohiko Sugiyama, Jun Takada, Masaya Kubota, Takashi Ibuka, Yohei Shirakami, Hiroshi Araki, Masahito Shimizu View Abstract ❯
Clinicopathological and biological analysis of PIK3CA mutation and amplification in cervical carcinomas Sultana Razia, Kentaro Nakayama, Kohei Nakamura, Tomoka Ishibashi, Masako Ishikawa, Toshiko Minamoto, Kouji Iida, Yoshiro Otsuki, Satoru Nakayama, Noriyoshi Ishikawa, Satoru Kyo View Abstract ❯
MicroRNA‑503 serves an oncogenic role in retinoblastoma progression by directly targeting PTPN12 Yang Cheng, Wei Liu View Abstract ❯
Efficacy of short‑term intensive treatment with insulin pump to improve islet β‑cell function in newly diagnosed type 2 diabetes via inhibition of oxidative stress Hai‑Tong Liu, Yan Gao View Abstract ❯
Incidence of fatalities of road traffic accidents associated with alcohol consumption and the use of psychoactive drugs: A 7-year survey (2011-2017) Athanasia H. Papalimperi, Sotirios A. Athanaselis, Areti D. Mina, Ioannis I. Papoutsis, Chara A. Spiliopoulou, Stavroula A. Papadodima View Abstract ❯
Ropivacaine vs. levobupivacaine: Analgesic effect of combined spinal‑epidural anesthesia during childbirth and effects on neonatal Apgar scores, as well as maternal vital signs Qiuju Cheng, Weiqiang Zhang, Yanling Lu, Jinhai Chen, Hang Tian View Abstract ❯
Silencing of long non‑coding RNA NCK1‑AS1 inhibits cell proliferation and migration via inhibition of microRNA‑134 in cervical cancer Lu Huang, Xiaoqin Gan, Li He, Luying Wang, Jie Yu View Abstract ❯
Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes Mengyao Ding, Ying Chen, Hengfei Luan, Xiaobao Zhang, Zhibin Zhao, Yong Wu View Abstract ❯
MicroRNA‑548b inhibits proliferation and invasion of hepatocellular carcinoma cells by directly targeting specificity protein 1 Haile Qiu, Gehong Zhang, Bin Song, Junmei Jia View Abstract ❯
SIRT1 is dispensable for maturation of hematopoietic stem cell in the bone marrow niche Su Min Park, Jayoung Kim, Chae Mi Hong, Dong Hoon Shin, Jee Yeon Kim, Do Youn Park, Dong Hyun Sohn, Yun Hak Kim, Sang‑Mo Kwon, Jae Ho Kim, Sun Sik Bae, Koanhoi Kim, Chi Dae Kim, Chi‑Dug Kang, Dongjun Lee View Abstract ❯
Correlation between coronary stenosis and Toll‑like receptors 2 and 4 levels in Chinese Zhuang patients with coronary heart disease Zhaohe Huang, Yan Liu, Limei Liang, Wenjing Liu, Suren R. Sooranna, Jianjiao Mo, Li Liu, Zhile Li, Kela Li, Jun Guo View Abstract ❯
[Retracted] Microarray profiling of long non­coding RNAs associated with idiopathic pulmonary arterial hypertension Bing Han, Peili Bu, Xiao Meng, Xiaoyang Hou View Abstract ❯

10-12 October, 2019, Mystras Grand Palace Resort, Sparta, Greece 24nd World Congress on Advances in Oncology & 24th International Symposium on Molecular Medicine 8-9 October 2019, Pre-Congress Workshop: 'SNP genotyping and rare mutation detection in cancer with molecular methods'

7-9 May, 2019, Grand Hotel, Duca D'Este, Rome, Italy 26 th International Symposium on Molecular Medicine

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com