Regulation of Foxe1 by Thyrotropin and Transforming Growth Factor Beta Depends on the Interplay Between Thyroid-Specific, CREB and SMAD Transcription Factors

Thyroid, Ahead of Print.


http://bit.ly/2SxbE9D

Duration of Hyperthyroidism and Lack of Sufficient Treatment Are Associated with Increased Cardiovascular Risk

Thyroid, Ahead of Print.


http://bit.ly/2DEdk7a

Risk Haplotypes Uniquely Associated with Radioiodine-Refractory Thyroid Cancer Patients of High African Ancestry

Thyroid, Ahead of Print.


http://bit.ly/2SwJUlK

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland

Thyroid, Volume 29, Issue 2, Page 161-173, February 2019.


http://bit.ly/2DEdbAE

Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study

Thyroid, Volume 29, Issue 2, Page 193-201, February 2019.


http://bit.ly/2SzRuMa

Concomitant Thyroid Cancer in Patients with Multiple Endocrine Neoplasia Type 1 Undergoing Surgery for Primary Hyperparathyroidism

Thyroid, Volume 29, Issue 2, Page 252-257, February 2019.


http://bit.ly/2DEd5cg

Therapeutic Effects of Short Cyclic and Combined Epitope Peptides in a Long-Term Model of Graves' Disease and Orbitopathy

Thyroid, Volume 29, Issue 2, Page 258-267, February 2019.


http://bit.ly/2SzXEfw

Thyroglobulin Is Markedly Elevated in 6- to 24-Month-Old Infants at Both Low and High Iodine Intakes and Suggests a Narrow Optimal Iodine Intake Range

Thyroid, Volume 29, Issue 2, Page 268-277, February 2019.


http://bit.ly/2DDGsv8

Correction to: Longitudinal Characterization of Autoantibodies to the Thyrotropin Receptor (TRAb) During Alemtuzumab Therapy: Evidence that TRAb May Precede Thyroid Dysfunction by Many Years by Muller I, Willis M, Healy S, Nasser T, Loveless S, Butterworth S, Zhang L, Draman MS, Taylor PN, Robertson N, Dayan CM, and Ludgate ME. Thyroid 2018;28:1682–1693. DOI: 10.1089/thy.2018.0232

Thyroid, Volume 29, Issue 2, Page 309-309, February 2019.


http://bit.ly/2SAmyM3

Future Meetings

Thyroid, Volume 29, Issue 2, Page 307-308, February 2019.


http://bit.ly/2DEcUO8

Primary Malignant Thyroid Teratoma: An Institutional Experience

Thyroid, Volume 29, Issue 2, Page 229-236, February 2019.


http://bit.ly/2SvqPQO

Long‐term functional and esthetic outcomes after fibula free flap reconstruction of the mandible

Abstract

Background

The goal of this study is to report functional and esthetic outcomes, after fibula free flap (FFF) reconstruction of the mandible for oral cancer, assessed by physicians, nonclinicians, and patients.

Methods

Twenty‐five long‐term survivors from oral cancer after FFF reconstruction were recalled for head and neck examination by surgeons, for photographs and patient‐reported outcomes, using EORTC, QLQ‐C30, H&N35, and FACE‐Q questionnaires.

Results

Physicians reported 64% restoration of functionality compared to normal. Patients reported high scores on QLQ‐C30 but lower scores on H&N35. Esthetic scores were reported higher by clinicians than nonclinicians. The decline in function and appearance was attributed to loss of lower dentition, trismus, malocclusion, xerostomia, and tissue atrophy.

Conclusion

To minimize the decline in function and appearance, immediate dental implants in FFF, better reconstruction of the temporomandibular joint, newer methods of radiotherapy to minimize xerostomia and oral exercises to prevent trismus should be considered.

http://bit.ly/2UXO7LI

Thermal water delivery in the nose: experimental results describing droplet deposition through computational fluid dynamics.

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Thermal water delivery in the nose: experimental results describing droplet deposition through computational fluid dynamics.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Buijs EFM, Covello V, Pipolo C, Saibene AM, Felisati G, Quadrio M

Abstract
Thermal water therapies have a role in treating various inflammatory disorders dating back to ancient Greece. Several studies have demonstrated beneficial effects of thermal water inhalations for upper respiratory disorders, such as improvement of mucociliary function and reduction of inflammatory cell infiltration. This experimental study describes the numerical investigation and clinical implications of thermal water droplet deposition in the nasal cavity of a single patient. To our knowledge, the numerical flow simulations described are the first investigations specifically designed for thermal water applications. To simulate nasal airflow, a patient-specific 3D computer model was created from a CT scan. The numerical approach is based on the Large Eddy Simulation (LES) technique and builds entirely upon open-source software. Deposition on mucosa was studied for two droplet sizes (5 and 10 µm diameter), corresponding to common thermal therapy applications (aerosol and vapour inhalation). The simulations consider steady inspiration at two different (low and moderate) breathing intensities. The results of this preliminary study show specific deposition patterns that favour droplet deposition in the middle meatus region to the inferior meatus, with particle size- and breathing intensity-related effects. These global data on particle deposition differ from findings related to the single-phase nasal airflow, which is more evenly distributed between the middle and inferior meatus. The potential clinical consequences of deposition data are discussed. The study furthermore provides evidence for the effectiveness of thermal aerosol and vapour inhalation therapies in reaching important areas of nasal mucosa with considerable clinical significance.

PMID: 30745596 [PubMed - as supplied by publisher]

http://bit.ly/2GoiXdm

Free flap head and neck reconstruction in the elderly: what is the impact on quality of life?

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Free flap head and neck reconstruction in the elderly: what is the impact on quality of life?

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Ferri A, Segna E, Varazzani A, Copelli C, Valsecchi S, Orabona GD, Baj A

Abstract
Morphofunctional reconstruction is a pivotal aspect in the surgery of head and neck neoplasms: nowadays, microvascular free flap surgery represents the gold standard. In choosing the surgical technique, the effects on residual quality of life, especially in elderly people, usually considered more fragile and so often excluded from microsurgical procedures, must be taken into account. This multicentre study evaluated the quality of life index in patients more than 75 years of age and who underwent to head and neck microsurgical reconstruction. Data from patients aged > 75 years at the time of major head and neck reconstruction conducted with free flaps between 1 January 2005 and 30 June 2015 were analysed retrospectively. We administered the Italian version of Quality of Life questionnaire SF-36, at least 24 months after surgery. Results were compared to those for the general Italian population of the same age. We enrolled 39 patients with an average age of 80.6 years. The results did not differ significantly from the reference population. The international literature has already shown that chronologic age is not a valid parameter to determine the surgical treatment modality. Even considering the quality of residual life, our study supports the indication for free-flap reconstruction of head and neck defects in the elderly, confirming its effectiveness in this population.

PMID: 30745595 [PubMed - as supplied by publisher]

http://bit.ly/2IaS66k

Barbed suture in oral cavity reconstruction: preliminary results.

Related Articles

Barbed suture in oral cavity reconstruction: preliminary results.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Crosetti E, Caracciolo A, Arrigoni G, Delmastro E, Succo G

Abstract
The purpose of this study is to evaluate the efficacy and safety of unidirectional barbed suture (V-Loc) compared to a standard monofilament stitch (Vicryl) in suturing of a free flap to local tissue after head and neck surgery for squamous cell carcinoma of the oral cavity. Complication rates, operative closure time, length of hospitalisation and costs were evaluated. The study cohort (group A) of 20 consecutive patients reconstructed using barbed stitches for suturing was prospectively compared to a control cohort (group B) of 20 consecutive patients reconstructed using conventional vicryl stitches. All patients were affected by squamous cell carcinoma of the tongue and underwent different types of glossectomy and reconstruction with free flaps. This analysis demonstrates the efficacy of the barbed suture compared with a standard monofilament stitch in terms of lower complication rate (15% group A, 30% group B), intra-operative closure times (486 minutes group A, 517 minutes group B), and length of hospitalisation (average length of hospitalisation 14.60 days group A, 16.85 days group B). These factors coupled with the use of a lower number of stitches compared with the standard stitches may compensate the increased cost of the barbed suture. In conclusion, this study demonstrates that the use of unidirectional barbed stitches for suturing of a free flap to the recipient site reduces the complication rate, principally in terms of dehiscence and fistula incidence, and reduces intra-operative time and length of hospitalisation. Based on these results and on the literature, the use of unidirectional barbed stitches can be considered as a safe and efficient alternative to conventional stitches for suturing of free flaps to local tissue.

PMID: 30745594 [PubMed - as supplied by publisher]

http://bit.ly/2E7DAs1

Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds.

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Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Goncalves M, Aubreville M, Mueller SK, Sievert M, Maier A, Iro H, Bohr C

Abstract
Probe-based confocal laser endomicroscopy (CLE) is an innovative technique for real-time, non-invasive analysis of the surface epithelium. While being successfully used for diagnosis by experts, this method has not yet been established in clinical routine, partly due to the lack of standards and criteria for classifying various lesions. Our aim was to determine the diagnostic value and inter-rater reliability of CLE in detecting malignant lesions of the vocal cords. 58 video sequences were extracted from the probe-based CLE (GastroFlex probe with a Cellvizio® laser system) examinations of 3 patients with squamous cell carcinomas and 4 patients with benign alterations of the vocal folds. Two ENT surgeons, who were blinded to the histological result, were asked to identify the sequences representing a carcinoma. We showed an accuracy, sensitivity, specificity, PPV and NPV of 91.38-96.55%, 100%, 87.8-95.2%, 77.27-89.47% and 100%, respectively, with an inter-rater reliability of k = 0.89 ("almost perfect agreement"). Probe-based CLE is a promising method for diagnosis and assessment of vocal fold lesions in vivo. Our results suggest that, with adequate training, the diagnostic value of this technique can be improved and potentially provide important information during oncological surgery.

PMID: 30745593 [PubMed - as supplied by publisher]

http://bit.ly/2V0qT85

Comparison of electroglottographic variability index in euphonic and pathological voice.

Related Articles

Comparison of electroglottographic variability index in euphonic and pathological voice.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Nacci A, Romeo SO, Cavaliere MD, Macerata A, Bastiani L, Paludetti G, Galli J, Marchese MR, Barillari MR, Barillari U, Berrettini S, Laschi C, Cianchetti M, Manti M, Ursino F, Fattori B

Abstract
In a recent study we introduced a new approach for analysis of the electroglottographic (ECG) signal. This method is based on the evaluation of variation of the EGG signal and its first derivative, through new software developed by the Pisan phoniatric school. This software is designed to extract quantitative indices related to the contacting and decontacting phases of the vocal folds during phonation. The software allows us to study the combined variability of vibration amplitude and velocity (i.e. the first derivative of the EGG signal). Pathological voices show a much more variable EGG signal compared to normal voices, since cordal vibration is made irregular due to the presence of glottis plane pathologies. With the aim of demonstrating the differences between normal and pathological voices relevant to combined vibration amplitude and velocity variability, we have introduced a new quantitative parameter named "variability index, VI". We studied 95 subjects (35 normal and 60 with pathological voice); among pathologic subjects, 15 showed functional dysphonia and 45 showed organic dysphonia. Subjects affected by organic dysphonia presented: 15 bilateral vocal nodules, 15 unilateral polyps and 15 unilateral cysts. All subjects were studied with videolaryngostroboscopy; electro-acoustic parameters of the voice were analysed with the KayPENTAX CSL (Model 4500) system. The EGG signal was recorded using KAY Model 6103 connected to the CSL system. The new software for the analysis of the EGG signal allows us to obtain not only a VI total value relevant to variability during all the recording, but also partial VI values relevant to the different glottis cycle phases. In fact, plotting the amplitude variation and its first derivative on a Lissajous graph, it is possible to divide the whole glottis cycle into four phases (each represented by four quadrants on the graph): the initial vocal folds contacting activity (VI-Q1), the last phase of vocal folds contacting (VI-Q2), the first phase of vocal folds decontacting (VI-Q3) and the last phase, up to the complete decontacting of vocal folds (VI-Q4). For each quadrant, it is also possible to work out the percent variability index. By comparing the variability indices in the normal and pathological groups, we obtained the following results: the total VI was significantly higher in the pathological subjects (0.25 vs 0.18; p = 0.01); the absolute value of VI was higher in pathological subjects, although the difference was not significant (VI-Q2, 0.041 vs 0.029; VI-Q3, 0.065 vs 0.058; VI-Q4, 0.054 vs 0.052). The percent variability in the Q2 quadrant (VI-Q2%) was significantly higher in pathological subjects compared to normal subjects (0.22 vs 0.16) (p = 0.01). The results of this study confirm that our new software for analysis of EGG signal can distinguish normal voice from pathological voice based on the new quantitative parameter VI, "variability index". Moreover, this study emphasises that the final contact phase of vocal folds is the most representative of the difference between the normal and pathological voice and shows a wider variability in terms of amplitude and vibration velocity. Further studies on larger groups of subjects will be required to confirm these results and assess differences in the EGG signal among the various vocal fold pathologies.

PMID: 30745592 [PubMed - as supplied by publisher]

http://bit.ly/2E6agSw

Comparative intraindividual ablative tissue effects of diode laser 980 nm versus radiofrequency in tonsillar hypertrophy management.

Related Articles

Comparative intraindividual ablative tissue effects of diode laser 980 nm versus radiofrequency in tonsillar hypertrophy management.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Kassab AN, Ahmed MR, Saber M, Mekawy S

Abstract
Tonsillotomy (tonsillar ablation) using diode laser and radiofrequency has been introduced for management of tonsillar hypertrophy as it is associated with fewer hazards to deep structures. We compared tissue volume and histological changes in the tonsils following radiofrequency tonsillotomy versus diode laser tonsillotomy in tonsillar hypertrophy. 40 tonsils excised from 20 patients were included in this study. Twenty tonsils were subjected to radiofrequency tonsillotomy (RFT) group 1, and the other 20 tonsils were subjected to diode laser 980 nm tonsillotomy (DLT) group 2. Both procedures were followed by cold dissection tonsillectomy for macroscopic and histological examination of tonsils. Tonsillar volume reduction was evident in both groups with a non-significant difference between groups. Histological changes were evident in both groups. In our study, both radiofrequency and diode laser were effective in tonsillar ablation in terms of volume reduction and keeping the histological pattern intact.

PMID: 30745591 [PubMed - as supplied by publisher]

http://bit.ly/2UXGUv9

Systemic inflammatory response after endoscopic surgery of Zenker's diverticulum.

Related Articles

Systemic inflammatory response after endoscopic surgery of Zenker's diverticulum.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Hering S, Wiegand S

Abstract
Zenker's diverticulum can be treated with a carbon dioxide laser or linear stapling device. A retrospective study on patients undergoing elective surgery for Zenker`s diverticulum with carbon dioxide laser or stapler was performed to analyse possible differences in inflammatory responses during the postoperative period. Leucocyte counts and C-reactive protein levels in peripheral blood were measured before and on days 1, 2, 3 and 5 after the operation. Statistical analysis was performed using the Mann-Whitney U-test. Of 34 patients, 16 were treated by laser and 18 by stapler. Age, sex ratio and ASA grade did not differ between the groups. Postoperative leukocytosis was significantly milder in the stapler group compared with patients who were treated by carbon dioxide laser. The mean C-reactive protein (CRP) level on day 1, 2 and 3 after surgery was significantly higher in the CO2 laser group than in the stapler group. Leukocyte counts recovered on day 3 after surgery in both groups while CRP levels did not decline to preoperative levels at day 5 after the operation in either group. No inflammatory complications such as mediastinitis or pneumonia occurred. In conclusion, the inflammatory response in the early period after carbon dioxide laser diverticulotomy of Zenker's diverticulum is higher than after stapler-assisted surgery of Zenker's diverticulum.

PMID: 30745590 [PubMed - as supplied by publisher]

http://bit.ly/2E6a4Ti

A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis.

Related Articles

A case of external auditory canal osteoma complicated with cholesteatoma, mastoiditis, labyrinthitis and internal auditory canal pachymeningitis.

Acta Otorhinolaryngol Ital. 2019 Jan 31;:

Authors: Iaccarino I, Bozzetti F, Piccioni LO, Falcioni M

Abstract
The association between external auditory canal osteoma and external auditory canal cholesteatoma is rare, with only a few reports in the current literature. Intracranial complications are very rare in the external auditory canal cholesteatoma, especially with direct propagation through the internal auditory canal. A case of 27-year-old male presenting with external auditory canal osteoma with secondary external auditory canal cholesteatoma is described. Progression of the disease created in turn a mastoiditis, labyrinthitis and pachymeningitis confined to the internal auditory canal. The patient was treated by a subtotal petrosectomy, without entering the internal auditory canal. A control MRI after 3 months showed reduction of the internal auditory canal enhancement.

PMID: 30745589 [PubMed - as supplied by publisher]

http://bit.ly/2UXiKBe