Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Alexandra Perea Polak, Elisabeth Gómez Moyano, Angel Vera Casaño, Leandro Martinez Pilar, Sara Simonsen, Beatriz Romero Madrid
Σάββατο 22 Σεπτεμβρίου 2018
Enfermedad de Grover en una paciente con enfermedad renal crónica en hemodiálisis
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Miguel Ángel Flores-Terry, Lucía González-Ruiz, Isabel María de Lara-Simón, Monserrat Franco-Muñóz
Síndrome de DRESS tras la administración intraperitoneal de vancomicina
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Xavier Fustà-Novell, Sebastian Podlipnik, Daniel Morgado-Carrasco, José Manuel Mascaró Jr
Pápulas de coloración de la piel y malformación del tracto urinario. Diagnóstico y comentario
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Víctor Alejandro González-Delgado, Liria Terrádez-Mas, José M. Martín
Un caso de pigmentación oral. Diagnóstico y comentario
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Felipe César Benavente-Villegas, Amparo Fuertes Prosper, Patricia Pose Lapausa
Telangiectasia hemorrágica hereditaria. Revisión a partir de un caso
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Emilio Vargas Ramírez, María Jesús Rojas-Lechuga, Pablo Uribe González
Dermatitis de contacto por acrilatos en kits caseros de esmaltes de uñas permanentes
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): María-Elena Gatica-Ortega, María-Antonia Pastor-Nieto
Dermoscopia del queratoacantoma en fase de regresión
Publication date: October 2018
Source: Piel, Volume 33, Issue 8
Author(s): Carlos Cuenca-Barrales, Jorge Juan Vega-Castillo, Jose Carlos Ruiz-Carrascosa, Ricardo Ruiz-Villaverde
Eficacia y seguridad de los cannabinoides tópicos en dermatología
Publication date: Available online 20 September 2018
Source: Piel
Author(s): Adrián Imbernón-Moya, Ricardo Ruiz-Rodríguez
Micosis fungoide hipopigmentada: la gran simuladora
Publication date: Available online 18 September 2018
Source: Piel
Author(s): Eduardo Garzón, John Jairo Dávila Rodríguez, Karla Aguilar Benavides, Ana Loaiza
Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?
Abstract
Chronic wounds remain a major unmet healthcare challenge, associated with substantial morbidity and economic costs. Therefore, novel treatment strategies and therapeutic approaches need to be urgently developed. Yet, despite the increasingly recognized importance of neurohormonal signaling in skin physiology, the neuroendocrine regulation of cutaneous wound healing has received surprisingly little attention. Human skin, and its appendages, locally express the pleiotropic neurohormone prolactin (PRL), which not only regulates lactation but also hair follicle cycling, angiogenesis, keratinocyte proliferation, and epithelial stem cell functions. Therefore, we examined the effects of PRL in experimentally wounded female human skin organ culture. Overall, this revealed that PRL slightly, but significantly, inhibited epidermal regeneration (reepithelialisation), cytokeratin 6 protein expression and intraepidermal mitochondrial activity (MTCO1 expression), while it promoted keratinocyte terminal differentiation (i.e. involucrin expression) ex vivo. If the current pilot data are confirmed by further studies, PRL may serve as one of the—rarely studied—negative regulators of cutaneous wound healing that control excessive reepithelialisation. This raises the intriguing and clinically relevant question of whether PRL receptor antagonists could actually promote epidermal repair after human skin wounding.
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
| Related Articles |
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Clin Cosmet Investig Dermatol. 2018;11:431-436
Authors: Sant'Anna Addor FA, Donato LC, Melo CSA
Abstract
Purpose: Telogen effluvium (TE) is defined as a diffuse hair loss characterized by shortening of the anagen phase and precipitation of the telogen phase, with a consequent reduction of total hair volume. Nutritional supplementation is indicated under conditions in which TE is related to dietary disorders. The aim of this clinical study was to compare the efficacy of two different supplements in monotherapy for TE.
Patients and methods: Female adult patients were randomized to receive two oral nutritional supplements (group 1: a supplement composed of zinc, biotin, iron, vitamins A, C, E, and B complex, folic acid, magnesium, and amino acids of keratin and collagen and group 2: calcium pantothenate cystine, thiamine nitrate, medicinal yeast, keratin, and aminobenzoic acid) to treat hair loss for 180 days. They were evaluated clinically and by digital trichoscopy.
Results: Clinical evaluation showed significant clinical improvement (P<0.05) for the evaluated parameters: hair loss, hair volume, density of hair (scalp cover), hair shine, hair strength, in 180 days. At 90 days evaluation, group 1 showed significant improvement for all parameters, while group 2 did not show any significant improvement for hair shine and hair strength. In the digital trichoscopy, there was a significant improvement only in group 1 (11.09%×7.76%) after 180 days.
Conclusion: In idiopathic TE, the nutritional component should be suspected; the supplementation of an association of nutrients in recommended daily intake can lead to significant improvement of the condition from the first trimester of use. The use of an association with proven efficacy and a safety profile and posologic convenience facilitate its indication and patient adherence.
PMID: 30237729 [PubMed]
Mucormycosis outbreak due to Rhizopus microsporus after arthroscopic anterior cruciate ligament reconstruction surgery evaluated by RAPD and MALDI-TOF Mass spectrometry
Publication date: Available online 22 September 2018
Source: Journal de Mycologie Médicale
Author(s): S. Gamarra, M.S. Chaves, M.S. Cabeza, D. Macedo, F. Leonardelli, D. Franco, M. Boleas, G. Garcia-Effron
Abstract
Background
Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. microsporum involving three young immunocompetent patients whom underwent arthroscopic anterior cruciate ligament reconstruction surgery in a seven-month time span.
Procedures
During the outbreak period, a total of 32 surgeries of this type were performed in the clinic (mucormycosis prevalence of 9.375%). The three patients presented healthcare-associated Mucormycosis comprising the bone surrounding one of the fixation screws (femoral or tibial). In addition to these three strains, another three R. microsporus strains isolated in the medical center during the same period of time were included in the study. One of these fungi was isolated from a skin lesion of a kidney transplant patient while the other two strains were isolated from environmental sources. Classical, mass spectrometry-based (MALDI-TOFF) and molecular identification were performed. Genetic relatedness was established by Rep-PCR (RAPD variant) and by single-linkage cluster analysis mass spectra. Cluster analysis was performed by unweighed pair group method with arithmetic mean (UPGMA).
Main findings
All the strains were identified as R. microsporum by the used phenotypic and genetic tools. Clinical strains fell into 2 different clusters separating the renal transplant recipient strain from the three strains isolated post ACLR surgery, which clustered together.
Conclusions
The established genetic/mass spectra relatedness between the three post-surgery isolates suggests that these cases may be considered a healthcare-associated mucormycosis outbreak.
Immune and Inflammatory Reponses to Staphylococcus aureus Skin Infections
Abstract
Purpose of Review
There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, Staphylococcus aureus (S. aureus). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to S. aureus skin infections.
Recent Findings
Antimicrobial peptides, pattern recognition receptors, and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against S. aureus skin infections. In addition, certain mechanisms by which S. aureus contributes to aberrant cutaneous inflammation, such as in flares of the inflammatory skin disease atopic dermatitis, have also been identified.
Summary
These cutaneous immune mechanisms could provide new targets for future vaccines and immune-based therapies to combat skin infections and cutaneous inflammation caused by S. aureus.
Preoperative liver registration for augmented monocular laparoscopy using backward–forward biomechanical simulation
Abstract
Purpose
Augmented reality for monocular laparoscopy from a preoperative volume such as CT is achieved in two steps. The first step is to segment the organ in the preoperative volume and reconstruct its 3D model. The second step is to register the preoperative 3D model to an initial intraoperative laparoscopy image. To date, there does not exist an automatic initial registration method to solve the second step for the liver in the de facto operating room conditions of monocular laparoscopy. Existing methods attempt to solve for both deformation and pose simultaneously, leading to nonconvex problems with no optimal solution algorithms.
Methods
We propose in contrast to break the problem down into two parts, solving for (i) deformation and (ii) pose. Part (i) simulates biomechanical deformations from the preoperative to the intraoperative state to predict the liver's unknown intraoperative shape by modeling gravity, the abdominopelvic cavity's pressure and boundary conditions. Part (ii) rigidly registers the simulated shape to the laparoscopy image using contour cues.
Results
Our formulation leads to a well-posed problem, contrary to existing methods. This is because it exploits strong environment priors to complement the weak laparoscopic visual cues.
Conclusion
Quantitative results with in silico and phantom experiments and qualitative results with laparosurgery images for two patients show that our method outperforms the state-of-the-art in accuracy and registration time.
Comparison of the application of B-mode and strain elastography ultrasound in the estimation of lymph node metastasis of papillary thyroid carcinoma based on a radiomics approach
Abstract
Purpose
B-mode ultrasound (B-US) and strain elastography ultrasound (SE-US) images have a potential to distinguish thyroid tumor with different lymph node (LN) status. The purpose of our study is to investigate whether the application of multi-modality images including B-US and SE-US can improve the discriminability of thyroid tumor with LN metastasis based on a radiomics approach.
Methods
Ultrasound (US) images including B-US and SE-US images of 75 papillary thyroid carcinoma (PTC) cases were retrospectively collected. A radiomics approach was developed in this study to estimate LNs status of PTC patients. The approach included image segmentation, quantitative feature extraction, feature selection and classification. Three feature sets were extracted from B-US, SE-US, and multi-modality containing B-US and SE-US. They were used to evaluate the contribution of different modalities. A total of 684 radiomics features have been extracted in our study. We used sparse representation coefficient-based feature selection method with 10-bootstrap to reduce the dimension of feature sets. Support vector machine with leave-one-out cross-validation was used to build the model for estimating LN status.
Results
Using features extracted from both B-US and SE-US, the radiomics-based model produced an area under the receiver operating characteristic curve (AUC) \(=\) 0.90, accuracy (ACC) \(=\) 0.85, sensitivity (SENS) \(=\) 0.77 and specificity (SPEC) \(=\) 0.88, which was better than using features extracted from B-US or SE-US separately.
Conclusions
Multi-modality images provided more information in radiomics study. Combining use of B-US and SE-US could improve the LN metastasis estimation accuracy for PTC patients.
Correction to: Tomosynthesis implementation with adaptive online calibration on clinical C-arm systems
The original version of this article unfortunately contained a mistake in table 2.
Eye tracker accuracy: quantitative evaluation of the invisible eye center location
Abstract
Purpose
We present a new method to evaluate the accuracy of an eye tracker-based eye localization system. Measuring the accuracy of an eye tracker's primary intention, the estimated point of gaze, is usually done with volunteers and a set of fixation points used as ground truth. However, verifying the accuracy of the location estimate of a volunteer's eye center in 3D space is not easily possible. This is because the eye center, the center of corneal curvature, is an intangible point.
Methods
We evaluate the eye location accuracy by using an eye phantom instead of eyes of volunteers. For this, we developed a testing stage with a realistic artificial eye and a corresponding kinematic model, which we trained with \(\mu \text {CT}\) data. This enables us to precisely evaluate the eye location estimate of an eye tracker.
Results
We show that the proposed testing stage with the corresponding kinematic model is suitable for such a validation. Further, we evaluate a particular eye tracker-based navigation system and show that this system is able to successfully determine the eye center with a mean accuracy of 0.68 mm.
Conclusion
We show the suitability of the evaluated eye tracker for eye interventions, using the proposed testing stage and the corresponding kinematic model. The results further enable specific enhancements of the navigation system to potentially get even better results.
Correction to: Radiation exposure for intraoperative 3D scans in a hybrid operating room: how to reduce radiation exposure for the surgical team
The original version of this article unfortunately contained a mistake. In abstract, results section should read.
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