This case series assesses the efficacy and tolerability of sirolimus as an adjuvant therapy for endovascular embolization in the management of complicated extracranial head and neck arteriovenous malformations.
Τετάρτη 19 Σεπτεμβρίου 2018
Translating Data on Trends in Disease Management to Decisions
Quantifying health care utilization is an important first step in understanding how to efficiently and effectively deliver health care to patients. Actinic keratoses (AKs) are among the most common clinical diagnoses encountered by dermatologists, and treatment aims to reduce patient discomfort and potential for malignant transformation. Given an aging population, disease burden will likely increase, highlighting the need for understanding trends in AK treatment and reimbursement.
Antiphospholipid Syndrome Following Pembrolizumab Treatment of Stage IIIB Unresectable Melanoma
The case report describes the occurrence of antiphospholipid syndrome following pembrolizumab treatment of stage IIIB unresectable melanoma.
Use of Actinic Keratosis Destruction in the Medicare Part B Fee-for-Service Population
This billing claims analysis uses the Medicare Part B Physician/Supplier Procedure Summary Master Files and National Summary Data to evaluate trends in the use and costs of actinic keratosis destruction.
Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP
The Journal of Dermatology, EarlyView.
“Market withdrawals” of medicines in Germany after AMNOG: a comparison of HTA ratings and clinical guideline recommendations
According to the AMNOG act, the German Federal Joint Committee (G-BA) determines the additional benefit of new medicines as a basis for subsequent price negotiations. Pharmaceutical companies may withdraw thei...
Unusual skin manifestations associated with parvovirus B19 primary infection in children
Pediatric Dermatology, EarlyView.
Screening of candidate gene responses to cadmium stress by RNA sequencing in oilseed rape ( Brassica napus L.)
Abstract
Cadmium (Cd) stress is one of the most serious threats to agriculture in the world. Oilseed rape (Brassica napus L.) is an important oil crop; however, Cd can easily accumulate in rapeseed and thus harm human health through the food chain. In the first experiment, our purpose was to measure the Cd accumulation in mature B. napus plants and its influences on fatty acid composition. The results showed that most Cd was accumulated in the root, and the seed fatty acid content was considerably different at different Cd toxicity levels. In the second experiment, 7-day-old B. napus seedlings stressed by Cd (1 mM) for 0 h (CK-0h), 24 h (T-24h), or 72 h (T-72h) were submitted to physiological and biological analyses, RNA-Seq and qRT-PCR. In total, 5469 and 6769 differentially expressed genes (DEGs) were identified in the comparisons of "CK-0h vs T-24h" and "CK-0h vs T-72h", respectively. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that the photosynthetic and glutathione (GSH) pathways were significantly enriched in response to Cd stress. Key factors in the response to Cd stress included BnPCS1, BnGSTU12, BnGSTU5, and BnHMAs. The transcription factors BnWRKY11 (BnaA03g51590D), BnWRKY28 (BnaA03g43640D), BnWRKY33 (BnaA03g17820D), and BnWRKY75 (BnaA03g04160D) were upregulated after Cd exposure. The present study revealed that upregulation of the genes encoding GST and PCS under Cd stress promoted the formation of low-molecular weight complexes (PC-Cd), and upregulation of heavy metal ATPase genes induced PC-Cd transfer to vacuoles. These findings may provide the basis for the molecular mechanism of the response of B. napus to Cd.
Schmerzhafte Lymphadenopathie nach Insektenstich – ein Fallbericht
Zusammenfassung
Tularämie ist eine bakterielle Zoonose, die meist durch Zecken- und Insektenstiche oder durch Kontakt mit dem Fleisch infizierter Tiere übertragen wird. Wir berichten über einen 36-jährigen Patienten, der nach einem Insektenstich am Abdomen Fieber, Schüttelfrost, Kopfschmerzen und eine einseitige, schmerzhafte, inguinale Lymphadenopathie mit rötlich-livider Verfärbung der umgebenden Haut entwickelte. Die Diagnose einer ulzeroglandulären Tularämie wurde mittels Polymerasekettenreaktion (PCR) und Serologie gestellt. Es wurde eine 21-tägige Therapie mit Doxycyclin durchgeführt, die zur Abheilung führte.
Pseudoxanthoma elasticum: Dermoscopy and mutation analysis
Australasian Journal of Dermatology, EarlyView.
A revisit of the environmental Kuznets curve hypothesis for Turkey: new evidence from bootstrap rolling window causality
Abstract
This study aims at analyzing the Environmental Kuznets Curve (EKC) hypothesis for Turkey, spanning the period of 1961–2013. Unlike previous studies, instead of carbon emissions, the ecological footprint is used as a proxy for environmental degradation. Moreover, a bootstrap time-varying causality approach is used to detect the possible changes in causal relations and to obtain the parameters across subsample periods. The results clearly indicate that there are feedback relationships between economic growth and the ecological footprint in some subsample periods. In addition, the impact of economic growth on environmental degradation is positive and has a slowly increasing trend in all subsample periods. Therefore, the EKC hypothesis is not confirmed for the Turkish economy. Based on these results, some crucial policy implications are suggested.
Disease Burden and Treatment Patterns of Psoriasis in Russia: A Real-World Patient and Dermatologist Survey
Abstract
Introduction
Data regarding disease burden and quality of life (QoL) for patients with psoriasis from Russia are limited. The objective of this study was to describe the demographic and clinical characteristics, comorbidities, and treatment patterns of systemic therapy eligible psoriasis patients in Russia in order to assess the impact of psoriasis on the QoL and work productivity of the patients and to evaluate patient/dermatologist concordance on disease severity, signs/symptoms, and satisfaction with psoriasis treatment.
Methods
Data were collected by the Growth from Knowledge Disease Atlas global real-world evidence programme from nine countries. The data from the Russian population are presented here. Adult patients who had a current or prior history of moderate-to-severe psoriasis and were receiving prescription treatment at the time of the survey were included. Dermatologist-reported data on disease severity, symptoms, comorbidities, and treatment as well as patient-reported data on QoL and work productivity were collected. Descriptive analysis of the data was conducted. Patient/dermatologist concordance was assessed using Cohen's κ.
Results
A total of 300 patients from Russia were included. The mean Psoriasis Area and Severity Index score was 9.0 and the mean disease duration was 9.9 years. The proportion of patients with itch, skin pain, and comorbidities increased as current psoriasis severity increased. The disease had a negative impact on patients' QoL (mean Dermatology Life Quality Index score: 7.1) and work productivity (33.2% drop in work productivity), which further deteriorated as disease severity increased. A large proportion of the enrolled patients (60%) were treated with topical agents only. Overall, the level of concordance between patients and their dermatologists regarding psoriasis severity and satisfaction with overall disease control achieved was low.
Conclusion
Results demonstrate a substantial disease burden on psoriasis patients in Russia, despite receiving treatment for their psoriasis, as well as low patient/dermatologist concordance of views on treatment outcomes. These findings also highlight a need to further incorporate the patient's views into treatment decision-making in Russia.
Funding
Novartis Pharma AG, Basel, Switzerland.
Acral Melanoma: A Patient’s Experience and Physician’s Commentary
Abstract
This article, co-authored by a patient diagnosed with acral melanoma, discusses the patient's experience of being diagnosed with and treated with surgery for this disease. The physician discusses the epidemiology, genetics, diagnosis, treatment, and prognosis of acral melanoma. Follow-up care plans are also discussed.
The physical and chemical disruption of human hair after bleaching – studies by transmission electron microscopy and redox proteomics
International Journal of Cosmetic Science, Volume 0, Issue ja, -Not available-.
Tolerability of isavuconazole after posaconazole toxicity in leukemia patients
Mycoses, Volume 0, Issue ja, -Not available-.
46th Annual Meeting of the Japanese Society for Wound Healing: Tokyo, Japan, December 9–10, 2016: Congress President: Hiromi Sanada PhD, RN, CWOCN, Professor of Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo
Wound Repair and Regeneration, EarlyView.
Εγγραφή σε:
Αναρτήσεις (Atom)
-
A Case of Diprosopus Tetraophthalmos: Ocular Findings and Surgical Treatment of Exposure KeratopathyDiprosopus is a rare variation of conjoined twinning. In this report, ophthalmic findings in an infant with diprosopus tetraophthalmos are p...
