Mapping sentinel lymph nodes in cutaneous melanoma: a vast array of perioperative imaging modalities

xlomafota13 shared this article with you from Inoreader Mapping sentinel lymph nodes in cutaneous melanoma: a vast array of perioperative imaging modalities Via Melanoma Research - Current Issue Sentinel lymph node biopsy (SLNB) is a decisive step in the staging process of melanoma, critically impacting patients' oncological outcome and driving the decision-making process. SLNB limits the extent of the dissection in cases where no metastases are found. Conversely, when metastases are detected, SLNB has the potential to improve regional control of the disease when complete lymphadenectomy or early administration of adjuvant treatment are indicated. Thus, accurately identifying sentinel lymph nodes represents an important prognostic factor. Several strategies have been studied, including novel procedur es that are not commonly used in the clinical setting. This review highlights the different tracers, preoperative and intraoperative imaging modalities studied to perform SLNB in cutaneous melanoma. The development of innovative modalities has been fueled by a need to optimize current approaches, offering new alternatives that can overcome some of the limitations of the standard method. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Immunohistochemistry analysis reveals lysyl oxidase-like 3 as a novel prognostic marker for primary melanoma

xlomafota13 shared this article with you from Inoreader Immunohistochemistry analysis reveals lysyl oxidase-like 3 as a novel prognostic marker for primary melanoma Via Melanoma Research - Current Issue Lysyl oxidase-like 3 (LOXL3) is an extracellular enzyme involved in the synthesis of collagen and elastin, and it has been reported to promote melanoma cell proliferation and invasion in vitro. However, the expression level of LOXL3 at different stages of melanocytic lesions and the role of LOXL3 in melanoma pathogenesis remain unknown. Immunohistochemical staining of LOXL3 in a tissue microarray of 373 biopsies at different melanocytic stages was conducted. The correlation between LOXL3 expression and patient survival was examined using Kaplan–Meier survival analysis. Univariate and multivariate Cox regres sion analyses were conducted to study the hazard ratios. The tissue microarray study revealed that stronger expression of LOXL3 protein was found at more advanced melanocytic stages (P  View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Comparitive Study of Endoscopic Skull Base Reconstruction in CSF rhinorrea using Nasoseptal Flap with Septal Cartilage v/s Fascia Lata With Fat

xlomafota13 shared this article with you from Inoreader A Comparitive Study of Endoscopic Skull Base Reconstruction in CSF rhinorrea using Nasoseptal Flap with  Septal Cartilage v/s Fascia Lata With Fat Via Otolaryngology Indian Abstract The objective of the study is to evaluate the surgical outcome between free nasoseptal mucoperichondrial flap using septal cartilage vs fascia lata using fat in terms of morbidity, hospital stay and postoperative complications. It is a retrospective comparitive study of 127 patients, diagnosed with CSF leak and who underwent repair of anterior skull base defect using free nasoseptal mucoperichondrial graft with septal cartilage in 73 cases compared with fascia lata with fat in 54 cases over the time frame of 5 years. The success rate with free nasoseptal flap with septal cartilage was 97.3% and that with fascia lata with fat was 96.3%. There was a significant association between mean hospital stay and the technique of CSF repair (unpaired t test, p −0.02). In our study the complications following the repair with free nasoseptal flap with septal cartilage was significantly less (p < 0.05, chi square test ). The above study concludes that in patients treated with free nasoseptal flap using septal cartilage has less hospital stay, less post-operative morbidity in the form of pain, movement and dependence for cleaning and dressing in comparison to fascia lata using fat. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Providing open-label placebos remotely—A randomized controlled trial in allergic rhinitis

xlomafota13 shared this article with you from Inoreader Providing open-label placebos remotely—A randomized controlled trial in allergic rhinitis Via Rhinitis by Tobias Kube, Verena E. Hofmann, Julia A. Glombiewski, Irving Kirsch Background Placebos can reduce physical symptoms even when provided with full honesty and disclosure. Yet, the precise mechanisms underlying the effects of "open-label placebos" (OLPs) have remained subject of debate. Furthermore, it is unclear whether OLPs are similarly effective when provided remotely, as is sometimes required e.g. in the current COVID-19 pandemic. Methods In a randomized-controlled trial, we examined the effects of OLP plus treatment as usual (TAU) compared to TAU alone on symptom reduction in people with allergic rhinitis (N = 54) over the course of two weeks. Due to the COVID-19 pandemic, OLP was provided remotely (i.e. sent via postal service). To investigate the potential influence of the clinical encounter on the effects of OLP, we manipulated the perception of the virtual clinical encounter, both with respect to verbal and nonverbal factors (augmented vs. limited encounter). Results The results of the manipulation check confirmed that the augmented clinical encounter was evaluated more positively than the limited encounter, in terms of perceived warmth of the provider. Participants from all treatment groups showed significant symptom reduction from baseline to two weeks later, but OLP had no incremental effect over TAU. Participants benefitted more from OLP when they did not take any other medication against allergic symptoms than when taking medication on demand. When controlling for baseline symptoms, a significant treatment by encounter interaction was found, pointing to greater symptom improvement in the OLP group when the encounter was augmented, whereas the control group improved more when the encounter was limited. Discussion The study demonstrates that providing OLP and enhancing the encounter remotely is possible, but their effectiveness might be lower in comparison to previous studies relying on physical patient-provider interaction. The study raises questions for future research about the p otential and challenges of remote placebo studies and virtual clinical encounters. The study has been registered as a clinical trial at ISRCTN (record number: 39018). View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tympanometrie zur Mittelohrdiagnostik

xlomafota13 shared this article with you from Inoreader Tympanometrie zur Mittelohrdiagnostik Via Sprache · Stimme · Gehör Sprache · Stimme · Gehör 2021; 45: 5-5 DOI: 10.1055/a-1256-2331 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Katzenschrei-Syndrom

xlomafota13 shared this article with you from Inoreader Message: Beim Cri-du-chat Syndrom handelt es sich um eine Chromosomenstörung, bei der ein Teil des kurzen Armes des Chromosoms 5 fehlt. Ein Wiederholungsrisiko besteht nur, wenn sich bei einem Elternteil auch eine Störung am Chromosom 5 findet (Translokation). Cri-du-chat Syndrom, Katzenschrei Syndrom - Medizin | UKBB Katzenschrei-Syndrom Via Sprache · Stimme · Gehör Sprache · Stimme · Gehör 2021; 45: 51-52 DOI: 10.1055/a-1256-2275 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Decreased retinal nerve fiber and choroidal thickness in chronic rhinosinusitis

xlomafota13 shared this article with you from Inoreader Decreased retinal nerve fiber and choroidal thickness in chronic rhinosinusitis Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 11. doi: 10.1007/s00405-020-06552-0. Online ahead of print. ABSTRACT PURPOSE: The assessment of the retina and choroid of patients with chronic rhinosinusitis (CRS), via spectral domain-optical coherence tomography (SD-OCT), was aimed in this study. We proposed that chronic upper airway restriction caused by chronic sinusitis could deteriorate the retinal and choroid morphology. METHODS: This prospective controlled study included a total of 90 eyes of 90 patients, 30 of whom were CRS with nasal polyposis (CRSwNP), 30 of whom were CRS without nasal polyposis (CRSsNP) and 30 of whom were healthy controls (HC). Only the right eye of the patients were evaluated. All patients underwent full otorhinolaryngologic and ophthalmologic examinations, including SD-OCT. RESULTS: Average retinal nerve fiber layer (RNFL) and RNFL in superior and inferior quadrants were measured significantly lower in CRS patients compared to HC. Ganglion cell-inner plexiform layer (GCIPL) thickness in all sectors was thinner in patients with CRS than in HC with significantly lower values in all sectors except inferior. Mean average GCIPL thickness and GCIPL thickness in the inferior sector were significantly lower in CRSwNP than CRSsNP patients. CONCLUSION: CRS may lead to thinning in the choroidal thickness, RNFL thickness, especially in the superior and inferior quadrants and GCIPL thickness, presumably related with hypoxia, endothelial dysfunction, inflammation and vascular dysregulation. Ocular manifestations of the CRS should be taken in the consideration during the management of this disease. PMID:33704528 | DOI:10.1007/s00405-020-06552-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tumor volume as a prognostic factor of locally advanced laryngeal cancer

xlomafota13 shared this article with you from Inoreader Tumor volume as a prognostic factor of locally advanced laryngeal cancer Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 11. doi: 10.1007/s00405-021-06734-4. Online ahead of print. NO ABSTRACT PMID:33704527 | DOI:10.1007/s00405-021-06734-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hidden Electrode Failure in a Cochlear Implant User

xlomafota13 shared this article with you from Inoreader Hidden Electrode Failure in a Cochlear Implant User Via The Laryngoscope When the impedance of an electrode contact is highly increased in a cochlear implant, a failure of the appropriate electrode seems obvious. We present a case where impedances of some electrodes were at the lower edge of the normal range and not regarded as suspicious neither by the clinical fitting software nor by in‐vivo tests conducted by the implant manufacturer. However, speech comprehension was substantially degraded and sound perception distorted. Also, on the affected electrodes, loudness perception was compromised and responses of the electrically evoked compound action potential were no longer measureable. After re‐implantation, the subjective sound percept was clear again and speech comprehension scored much better than before. Later, inspection of the explant revealed shorts on the device and the implant was classified as device failure. Our case shows the importance of collecting longitudinal data of cochlear implant patients, i.e. device rel ated technical measurements and hearing performance data, and the consideration of all these data in cases of patient complaints or suspected implant failures. Laryngoscope, 131:E1275–E1278, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tracing the Origins of “Cauliflower Ear” and Its Earlier Names over Two Millenia

xlomafota13 shared this article with you from Inoreader Tracing the Origins of "Cauliflower Ear" and Its Earlier Names over Two Millenia Via The Laryngoscope Objectives The post‐traumatic ear deformity, known today as cauliflower ear, has been described since antiquity. It has long been associated with pugilistic sports (wrestling, boxing) as well as among the mentally ill. The aim of this study is to present the various terms used since antiquity to describe these traumatic deformations of the auricle and to trace the origin of the modern moniker "cauliflower ear." Methods Historical study, only based on original documentation accessed through personal libraries and universities repositories, completed with online sources and etymological dictionaries. Results We were able to identify no fewer than 39 names for the deformity. The term cauliflower ear is of relatively recent origin. It was coined in the first decade of the 20th century, initially in the popular press and subsequently adopted by the medical profession. Conclusion Ironically, the deformity has only superficial resemblance to a cauliflower. The vegetable, which is part of the cabbage family, has a symmetrical and highly ordered fractal geometry with well‐circumscribed excrescences. Cauliflower ear, by contrast, notably lacks symmetry and its rounded protuberances flow into one another. Although somewhat a misnomer, the term is deeply rooted in both popular and medical culture. Level of Evidence N/A Laryngoscope, 131:E1315–E1321, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population‐Based Study

xlomafota13 shared this article with you from Inoreader Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population‐Based Study Via The Laryngoscope Objective The progression and asymmetry of age‐related hearing loss has not been well characterized in those 80 years of age and older because public datasets mask upper extremes of age to protect anonymity. We aim to characterize the progression, severity, and asymmetry of hearing loss in those 80 years of age and older using a representative, national database. Methods Cross‐sectional, multicentered U.S. epidemiologic analysis using the National Health and Nutrition Examination Survey (NHANES) 2005 to 2006, 2009 to 2010, and 2011 to 2012 cycles. Subjects included noninstitutionalized, civilian adults aged 80 years and older (n = 621). Federal security clearance was granted to access publicly restricted age data. Outcome measures included pure‐tone average (PTA) air conduction thresholds and the 4‐frequency PTA. Results Six hundred and twenty‐one subjects were 80 years old or older (mean = 84.2 years, range = 80–104 years), representing 10,600,197 Americans. The average PTA was 38.9 dB (95% confidence interval [CI] = 37.8, 40.0). Hearing loss exhibited constant acceleration across the adult lifespan at a rate of 0.0052 dB/year2 (95% CI = 0.0049, 0.0055). This model predicted mean PTA within 2 dB of accuracy for most ages between 20 and 100 years. From age 80 years to approximately 100 years, the average PTA difference between the better and worse ear was 6.75 dB (95% CI = 5.8, 7.1). This asymmetry was relatively constant (i.e., nonsignificant linear regression coefficient of asymmetry over age = 0.07 [95% CI = −0.01, 0.2]). Conclusion Hearing loss steadily and predictably accelerates across the adult lifespan to at least age 100 years, becoming near universal. These population‐level statistics will guide treatment and policy recommendations for hearing health in the older old. Level of Evidence 3 Laryngoscope, 131:879–884, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Management of the Disrupted Airway in Children

xlomafota13 shared this article with you from Inoreader Management of the Disrupted Airway in Children Via The Laryngoscope Objective Our objective was to gather data that would enable us to suggest more specific guidelines for the management of children with airway disruption. Study Design Retrospective case series with data from five tertiary medical centers. Methods Children younger than 18 years of age with a disrupted airway were enrolled in this series. Data pertaining to age, sex, etiology and location of the disruption, type of injury, previous surgery, presence of air extravasation, management, and outcome were obtained and summarized. Results Twenty children with a mean age of 4.4 years (range 1 day–14.75 years) were included in the study. All were evaluated by flexible endoscopy and/or microlaryngoscopy in the operating room. Twelve (60%) children had tracheal involvement; seven had bronchial involvement; and one had involvement of the cricoid cartilage. Nine children had air extravasation, and all these children required surgical repair. Of the 11 who did not have air extravasation, only one underwent surgical repair. Complete healing of the disrupted airway was seen in all cases. Conclusion This series suggests that if there is no continuous air extravasation demonstrated on imaging studies or clinical examination, nonoperative management may allow for spontaneous healing without sequelae. However, surgical repair may be considered in those patients with continuous air extravasation unless a cuffed tube can be placed distal to the site of injury. For children in whom airway injury occurs in a previously operated area, the risk of extravasation is reduced. This risk is also diminished if positive pressure ventilation can be avoided or minimized. Level of Evidence 4 Laryngoscope, 131:921–924, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.