Pediatric Dermatology, EarlyView.
Κυριακή 24 Ιουνίου 2018
Atypical maculopapular cutaneous mastocytosis showing a nevus spilus‐like lesion
Divided or kissing nevus of the penis: A new case with dermoscopic findings
Pediatric Dermatology, EarlyView.
Impact of naevus association on survival for nodular and superficial spreading melanomas
British Journal of Dermatology, EarlyView.
Issue Information
Clinical and Experimental Dermatology, Volume 43, Issue 5, Page i,511-512, July 2018.
Exploring Bioluminescence Function of the Ca2+‐regulated Photoproteins with Site‐directed Mutagenesis
Photochemistry and Photobiology, EarlyView.
NDRG1 and FOXO1 regulate endothelial cell proliferation in infantile haemangioma
Experimental Dermatology, Volume 27, Issue 6, Page 690-693, June 2018.
No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles
Experimental Dermatology, Volume 27, Issue 6, Page 668-671, June 2018.
A guide to studying human dermal adipocytes in situ
Experimental Dermatology, Volume 27, Issue 6, Page 589-602, June 2018.
Methadone—Not a magic bullet in melanoma therapy
Experimental Dermatology, Volume 27, Issue 6, Page 694-696, June 2018.
Digital analysis yields more reliable and accurate measures of dermal and epidermal thickness in histologically processed specimens compared to traditional methods
Experimental Dermatology, Volume 27, Issue 6, Page 687-690, June 2018.
Generalized morphea in the setting of pembrolizumab
International Journal of Dermatology, EarlyView.
A giant mass on the scalp: an unusual presentation of lupus vulgaris
International Journal of Dermatology, EarlyView.
Synthesis and characterization of carboxymethyl chitosan/Fe3O4 and MnFe2O4 nanocomposites hydrogels for loading and release of curcumin
Publication date: Available online 23 June 2018
Source:Journal of Photochemistry and Photobiology B: Biology
Author(s): Zahra Naderi, Javad Azizian
This paper presents the preparation of hydrogel with magnetic properties derived from carboxymethyl chitosan for controlled drug release performance. The magnetic Fe3O4 and MnFe2O4 nanoparticles with crosslinked Carboxymethyl Chitosan hydrogel were prepared by using epichlorohydrin as the cross-linker. The structure characterization performed by FT-IR. The XRD analysis was applied for evaluation of crystalline phase of MnFe2O4 and Fe3O4 in the hydrogels. The crystallite size of Fe3O4/CMCS and MnFe2O4/CMCS was calculated to be 30.12, and 44.51 nm, respectively. The presence of MnFe2O4 and Fe3O4 in the hydrogels can reason a rough surface morphology which that confirmed by SEM images. The Max. Saturation magnetization value as obtained from hysteresis loop is 105 and 75 Am2/kg for Fe3O4/CMCS and MnFe2O4/CMCS hydrogel, respectively. The Fe3O4 and MnFe2O4 on Carboxymethyl Chitosan hydrogels indicated a pH-sensitive for swelling behavior process. The equal amount of Fe3O4 and MnFe2O4 on hydrogels have high swelling at pH 6.4. The swelling capacity decreased from 214 to 172% and 144–114% at pH 6.4 with attendance of high amount of MnFe2O4 and Fe3O4 on hydrogels compared to other samples, respectively. Drug loading and release performances were investigated by curcumin as a model drug. The maximum curcumin release was obtained 25.1–51.52% at pH = 6.4. The drug releases system demonstrates the high ratio of Fe3O4 and MnFe2O4 containing Carboxymethyl Chitosan sample has a great efficiency in curcumin release. The effect of applied magnetic field on drug release for Fe3O4/CMCS was highest compared to MnFe2O4/CMCS. The results demonstrated that the Fe3O4 and MnFe2O4 nanocomposites hydrogel can be applied for novel drug delivery systems.
Topical Application of Photofrin® for Photodynamic Diagnosis of Malignant Cutaneous Neoplasms
Publication date: Available online 23 June 2018
Source:Journal of Plastic, Reconstructive & Aesthetic Surgery
Author(s): Yu-Te Lin, Yen-Chang Hsiao, Yu-Fan Chiang, Cheng-Jen Chang
ObjectivesThe prognosis of patients suffering from malignant cutaneous neoplasms can be improved by early diagnosis. Exact demarcation of tumor margins could contribute to optimum results in surgical excision and reconstruction. The purpose of our study is to evaluate Photofrin® with a new diagnostic procedure, photodynamic diagnosis (PDD), for the detection of Bowen's disease (squamous cell carcinoma in situ), squamous cell carcinoma (SCC), and basal cell carcinoma (BCC).Materials and methodsSixty patients with cutaneous neoplasms received 2.5mg/mL Photofrin® solution topically. After a period of three hours, the patients underwent fluorescence illumination (λex = 370-450 nm). Guided by their visible fluorescence, lesions were biopsied at four suspicious sites on each patient. All specimens were analyzed and measured by a pathologist. A quantitative analysis of the fluorescence contrast between the neoplasms and healthy tissue was performed using the RGB Mode (Red, Blue, Green) and GS (Gray Scale). Statistical analysis was performed by means of the ANOVA test for multiple comparisons.ResultsOf the 60 patients (20 Bowen's disease, 20 squamous cell carcinoma, and 20 basal cell carcinoma), malignant neoplasms could be clearly distinguished from adjacent healthy tissue under fluorescence illumination (P<0.0001). The sensitivity of the malignant neoplasms could be evaluated using the RGB and GS modes combined and shown in image results of 92.74%. The specificity of the malignant neoplasms evaluated using the RGB and GS modes combined showed 95.77%.ConclusionLight-induced fluorescence detection using topical Photofrin® provides a sensitive, non-invasive technique for the early identification of malignant cutaneous neoplasms.
Potentially toxic elements in fly ash dependently of applied technology of hard coal combustion
Abstract
Coal combustion is one of the most significant anthropogenic sources of thallium in the environment. This study presents the results of determination of thallium and some toxic elements (Pb, Cd, As, Ni, Zn, and Cu) concentration in fly ash produced in the coal combustion in conventional furnaces (pulverized coal furnace and grate furnace), in a fluidized-bed furnace with circulation bed, and in a home furnace. The high content of thallium was determined in ash produced in the grate furnace (on average 10.7 mg/kg) and fluidized-bed furnace with circulation bed (6.6 mg/kg). The average content of Tl in the fly ash of the pulverized coal furnace and in the home furnace is 1.7 and 2.4 mg/kg, respectively. There was a strong relationship between the occurrence of Tl and As, Cd, Pb, Cu, and Zn in ash from grate and pulverized coal furnace.
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A Case of Diprosopus Tetraophthalmos: Ocular Findings and Surgical Treatment of Exposure KeratopathyDiprosopus is a rare variation of conjoined twinning. In this report, ophthalmic findings in an infant with diprosopus tetraophthalmos are p...
