Oral exercises significantly improve oral functions in people with mild and moderate dementia: a randomized controlled study

xlomafota13 shared this article with you from Inoreader Oral exercises significantly improve oral functions in people with mild and moderate dementia: a randomized controlled study Via swallowing exercises J Oral Rehabil. 2022 Mar 11. doi: 10.1111/joor.13317. Online ahead of print. ABSTRACT BACKGROUND: There have been no standard protocols of oral exercises for maintaining and improving oral function for people with dementia. OBJECTIVE: This study aimed to determine the effects of home-based oral exercises on the oral function of people with mild to moderate dementia. METHODS: Twenty-two participants at King Chulalongkorn Memorial Hospital were randomly assigned to exercis e group (n = 11) or control group (n = 11). The exercise group was instructed to do three home-based oral exercises, consisting of tongue-strengthening, oral diadochokinesis (ODK), and mouth-opening exercises, for 3 months, while the control group received advice on oral health care. The maximum tongue pressure (MTP) was the primary outcome. MTP, ODK rates of /pa/, /ta/, /ka/, modified water swallowing test (MWST), and oral moisture were measured at baseline, and after 1, 2, and 3 months of training. The generalized estimating equation analysis was used to evaluate the effects of oral exercises on the oral function. RESULTS: The MTP and all ODK rates in the exercise group were significantly increased after 3 months of training. There were significant interaction effects between time and intervention in MTP and all ODK rates. No significant interaction effects between time and intervention in oral moisture were found. The MWST scores in both groups did not change through the en d of study and no adverse effects were reported. CONCLUSION: Home-based oral exercises were found to be effective for improving tongue strength and tongue-lip motor function in people with mild to moderate dementia. PMID:35274344 | DOI:10.1111/joor.13317 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Indications and outcomes for elective dissection of level V in primary parotid cancer

xlomafota13 shared this article with you from Inoreader Indications and outcomes for elective dissection of level V in primary parotid cancer Via Head & Neck Abstract Background The extent of cervical lymphadenectomy required for primary parotid cancer is not well-established. Methods In this retrospective case–control study, 84 patients who underwent primary parotidectomy and neck dissection for primary parotid cancer between 2010 and 2019 were identified and analyzed. Results Of the 84 patients, 37 underwent elective level V neck dissection. All six (16.0%) who had occult level V nodes had clinically evident, preoperative anterior cervical metastases, a statistically significant finding. No other clinical factors are correlated with posterior neck involvement. There was no significant difference in disease-free or overall survival for patients with occult level V disease relative to positive lymph nodes in other levels. Conclusions Patients with clinically evident anterolateral cervical lymphatic metastases from parotid cancer preoperatively have high rates of occult level V nodes. Level V neck dissection can be avoided in cN0 patients and offered no survival advantage. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Experimental model of unpredictable maternal stress and diabetes risk of offspring: An immunohistochemical study

xlomafota13 shared this article with you from Inoreader Experimental model of unpredictable maternal stress and diabetes risk of offspring: An immunohistochemical study Via histochem Acta Histochem. 2022 Mar 15;124(3):151878. doi: 10.1016/j.acthis.2022.151878. Online ahead of print. ABSTRACT The effect of stress on the occurrence of diabetes mellitus (DM) is commonly reported in recent studies. Maternal stress may have a negative effect on the later life of offspring. However, most studies only investigated long-term intrauterine stress on behavioral, emotional, psychological, and immunological disorders of offspring. The relationship between maternal st ress and DM occurrence in the later life period of offspring is not known. This rat model study aimed to evaluate the susceptibility of offspring to DM after exposure to intrauterine stress. The purpose of this study is to examine serum glucose levels of mothers and offspring exposed to maternal stress and to evaluate pancreatic tissues pathologically and immunohistochemically. Twelve, Wistar Albino female rats were equally divided into two groups: controls and maternal stress groups. Normal routine conditions were applied to the control group without any stress. The pregnant rats in the maternal stress group were exposed to chronic unpredictable stressors throughout the 21-day gestation. One female and one male offspring and mothers from each term delivery were randomly selected and euthanatized at the 35th day. During the necropsy, blood and pancreatic tissue samples were collected from both mothers and pups. High serum glucose levels from mothers and offspring in the maternal str ess group and the control group were compared. Additionally, histopathological examinations assessed the increased cell degeneration in mother rats and offspring. Immunohistochemical examinations revealed decreased insulin, amylin, and insulin receptor expressions and slightly increased glucagon expression in Langerhans islet cells in the maternal stress group. These results indicated that maternal stress may be a predisposing factor for DM in both mothers and offspring in their later life periods. PMID:35303510 | DOI:10.1016/j.acthis.2022.151878 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Rodlet cells in kidney of goldfish (Carassius auratus, Linnaeus 1758): A light and confocal microscopy study

xlomafota13 shared this article with you from Inoreader Rodlet cells in kidney of goldfish (Carassius auratus, Linnaeus 1758): A light and confocal microscopy study Via histochem Acta Histochem. 2022 Mar 15;124(3):151876. doi: 10.1016/j.acthis.2022.151876. Online ahead of print. ABSTRACT Rodlet cells (RCs) have always been an enigma for scientists. RCs have been given a variety of activities over the years, including ion transport, osmoregulation, and sensory function. These cells, presumably as members of the granulocyte line, are present only in teleosts and play a role in the innate immune response. RCs are migratory cells found in a variety of or gans, including skin, vascular, digestive, uropoietic, reproductive, and respiratory systems, and present distinct physical properties that make them easily recognizable in tissues and organs. The development of RCs can be divided into four stages: granular, transitional, mature, and ruptured, having different morphological characteristics. Our study aims to characterize the different stages of these cells by histomorphological and histochemical techniques. Furthermore, we characterized these cells at all stages with peroxidase and fluorescence immunohistochemical techniques using different antibodies: S100, tubulin, α-SMA, piscidin, and for the first time TLR-2. From our results, the immunoreactivity of these cells to the antibodies performed may confirm that RCs play a role in fish defense mechanisms, helping to expand the state of the art on immunology and immune cells of teleosts. PMID:35303512 | DOI:10.1016/j.acthis.2022.151876 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

'Internal mammary artery perforator flap for anterior thoracic and upper abdominal wall reconstruction: 16 case series'

xlomafota13 shared this article with you from Inoreader "Internal mammary artery perforator flap for anterior thoracic and upper abdominal wall reconstruction: 16 case series" Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Feb 26:S1748-6815(22)00105-X. doi: 10.1016/j.bjps.2022.02.027. Online ahead of print. NO ABSTRACT PMID:35304858 | DOI:10.1016/j.bjps.2022.02.027 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extensor indicis proprius transfer for the extensor pollicis longus tendon rupture with a two-incision technique

xlomafota13 shared this article with you from Inoreader Extensor indicis proprius transfer for the extensor pollicis longus tendon rupture with a two-incision technique Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Mar 2:S1748-6815(22)00129-2. doi: 10.1016/j.bjps.2022.02.047. Online ahead of print. NO ABSTRACT PMID:35304851 | DOI:10.1016/j.bjps.2022.02.047 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Relationship Between Pitch Discrimination and Acoustic Voice Measures in a Cohort of Female Speakers

xlomafota13 shared this article with you from Inoreader The Relationship Between Pitch Discrimination and Acoustic Voice Measures in a Cohort of Female Speakers Via Journal of Voice Evidence across a range of musically trained, hearing disordered and voice disordered populations present conflicting results regarding the relationship between pitch discrimination (PD) and voice quality. PD characteristics of female speakers with and without a musical training background and no self-reported voice disorder, and the relationship between PD and voice quality in this particular population, have not been investigated. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

xlomafota13 shared this article with you from Inoreader BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 19. doi: 10.1007/s00405-022-07320-y. Online ahead of print. ABSTRACT PURPOSE: Obesity is a growing, global health problem and previous cross-sectional studies have demonstrated an association between obesity and chronic rhinosinusitis (CRS). There is, however, a lack of prospective studies regarding the impact of obesity on developing (new-onset) CRS. METHODS: Questionnaire-based data (n = 5769) relating to new-onset CRS and Body Mass Index (BMI) were collected in 2013 and 2018 from the Telemark population study in Telemark, Norway. Odds ratios for the risk of new-onset CRS in 2018 in relation to BMI in 2013 were calculated, adjusted for smoking habits, asthma, gender and age. RESULTS: When comparing the group with normal weight (18.5 ≤ BMI < 25) with the obese group (BMI ≥ 30), the odds of new-onset CRS was 53% higher [OR 1.53 (1.11, 2.10)] in the obese group. CONCLUSION: CR S is a multifactorial disease with different phenotypes and it is important to consider obesity when assessing patients with CRS in a clinical setting. PMID:35305138 | DOI:10.1007/s00405-022-07320-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Molecular diagnosis and targeted treatment of advanced follicular cell-derived thyroid cancer in the precision medicine era

xlomafota13 shared this article with you from Inoreader Molecular diagnosis and targeted treatment of advanced follicular cell-derived thyroid cancer in the precision medicine era Via radioactive iodine Cancer Treat Rev. 2022 Mar 15;106:102380. doi: 10.1016/j.ctrv.2022.102380. Online ahead of print. ABSTRACT Most malignant thyroid tumours are initially treated with surgery or a combination of surgery and radioactive iodine (RAI) therapy. However, in patients with metastatic disease, many tumours become refractory to RAI, and these patients require alternative treatments, such as locoregional therapies and/or systemic treatment with multikinase inhibitors. Improvements in our under standing of the genetic alterations that occur in thyroid cancer have led to the discovery of several targeted therapies with clinical efficacy. These alterations include NTRK (neurotrophic tyrosine receptor kinase) gene fusions, with the tropomyosin receptor kinase inhibitors larotrectinib and entrectinib both approved by the European Medicines Agency and in other markets worldwide. Inhibitors of aberrant proteins resulting from alterations in RET (rearranged during transfection) and BRAF (B-Raf proto-oncogene) have also shown promising efficacy, and so far have received approval by the US Food and Drug Administration. Selpercatinib, a RET kinase inhibitor, was approved for use in Europe in early 2021. With the discovery of multiple actionable targets, it is imperative that effective testing strategies for these genetic alterations are integrated into the diagnostic armamentarium to ensure that patients who could potentially benefit from targeted treatments are identified. In this review, we offer our recommendations on the optimal testing strategies for detecting genetic alterations in thyroid cancer that have the potential to be targeted by molecular therapy. We also discuss the future of treatments for thyroid cancers, including the use of immune checkpoint inhibitors, and new generations of targeted treatments that are being developed to counter acquired tumour resistance. PMID:35305441 | DOI:10.1016/j.ctrv.2022.102380 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effects of Cricothyroid Visor Maneuver (CVM) therapy on the voice characteristics of patients with muscular tension dysphonia: A Case Series Study

xlomafota13 shared this article with you from Inoreader The effects of Cricothyroid Visor Maneuver (CVM) therapy on the voice characteristics of patients with muscular tension dysphonia: A Case Series Study Via Journal of Voice The purpose of this study was to assess the effects of a novel manual therapy, the Cricothyroid visor maneuver (CVM) therapy, on acoustic, auditory perceptual and self-assessment ratings in Muscle tension dysphonia (MTD) patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Manual Therapy for Patients With Radiation-Associated Trismus After Head and Neck Cancer

xlomafota13 shared this article with you from Inoreader Manual Therapy for Patients With Radiation-Associated Trismus After Head and Neck Cancer Via JAMA Otolaryngology–Head & Neck Surgery Online First This case series study examines the effect size and associations of response to manual therapy to increase oral opening in the setting of radiation-associated trismus. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acute anterior thigh compartment syndrome in Premiership rugby

xlomafota13 shared this article with you from Inoreader Acute anterior thigh compartment syndrome in Premiership rugby Via swallowing exercises BMJ Case Rep. 2022 Mar 15;15(3):e247307. doi: 10.1136/bcr-2021-247307. ABSTRACT A case study of acute compartment syndrome in the anterior lateral thigh of a professional Rugby Union Flanker with no history of trauma is presented. The report covers all details from initial occurrence; medical history; investigations and surgical treatment; manual stimulus and rehabilitation; return to play; challenges and considerations-resulting in a positive outcome. Resultant observations/recomm endations are that investigations should be swift and carefully considered to facilitate surgical intervention via decompressive fasciotomy as required. PMID:35292543 | DOI:10.1136/bcr-2021-247307 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.