Nasal polyp fibroblasts (NPFs)-derived exosomes are important for the release of vascular endothelial growth factor from cocultured eosinophils and NPFs

xlomafota13 shared this article with you from Inoreader Nasal polyp fibroblasts (NPFs)-derived exosomes are important for the release of vascular endothelial growth factor from cocultured eosinophils and NPFs Via Auris Nasus Larynx Publication date: Available online 1 November 2021 Source: Auris Nasus Larynx Author(s): Shino Shimizu, Ichiro Tojima, Keigo Nakamura, Hiroyuki Arai, Hideaki Kouzaki, Takeshi Shimizu View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Biomarkers of human papillomavirus (HPV)‐driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16INK4a status

xlomafota13 shared this article with you from Inoreader Biomarkers of human papillomavirus (HPV)‐driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16INK4a status Via Head & Neck Abstract Background Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16INK4a immunohistochemistry. Results HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Anterior cruciate ligament innervation in primary knee osteoarthritis

xlomafota13 shared this article with you from Inoreader Anterior cruciate ligament innervation in primary knee osteoarthritis Via Cellular and Molecular Biology Histol Histopathol. 2021 Nov 2:18389. doi: 10.14670/HH-18-389. Online ahead of print. ABSTRACT OBJECTIVE: To relate the Anterior Cruciate Ligament (ACL) innervation and histologic degeneration status to the knee osteoarthritis radiologic and functional status. DESIGN: Prospective observational study including 30 consecutive patients affected by primary knee osteoarthritis undergoing Total Knee Arthroplasty (TKA). All patients suffering secondary knee osteoarthritis, an antecedent of an infectious process, malignant process, autoimmune disorder, or previous knee surgery were excluded. We recorded biodemographic, clinical, and radiologic variables of all participants previous to the TKA procedure. ACL tissue was harvested during TKA standard procedure and the obtained sample was fixed in 4% formalin and paraffin-embedded. ACL cross-sections were stained by haematoxylin-eosin and Gallego staining for elastic and collagen fibers, and Sevier-Munger silver staining for nervous tissue. RESULTS: ACL samples histologic degeneration classification reported 15.4% normal, 23.1% slight, 26.9% mild, 11.5% moderate and 23.1% marked. We noted 46.2% large nervous fascicles, 15.4% medium fascicles, 3.8% small fascicles, and no nerve fibers were found in 34.6% ACL samples. No significant correlation was found between the histologic degeneration and the nervous fiber quantification (p>0.05, in all cases). We noted a significant histologic degeneration inverse correlation with the VAS scale (p=0.016), and nervous fiber quantification correlation with Lequesne maximum distance walked punctuation (p=0.043). We also noted greater nervous fiber quantification with minor radiological knee osteoarthritis (Kellgren-Lawrence grade II). CONCLUSIONS: ACL degeneration and innervation deficit may play a role in primary knee osteoarthritis onset, but the lack of a defining relationship among the different parameters assessed justifies further research in greater populations. PMID:34725806 | DOI:10.14670/HH-18-389 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of demographic, audiologic, and hearing-aid-related variables on the outcomes of using hearing aids

xlomafota13 shared this article with you from Inoreader Effects of demographic, audiologic, and hearing-aid-related variables on the outcomes of using hearing aids Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Nov 1. doi: 10.1007/s00405-021-07126-4. Online ahead of print. ABSTRACT PURPOSE: To examine the influence of demographic, audiologic, and hearing-aid (HA)-related variables on HA outcomes. METHODS: In total, 235 adults with hearing loss (HL) who used HAs for at least 3 months were included in the study, and completed audiologic tests and the Chinese version of the International Outcome Inventory for Hearing Aids (IOI-HA). Spearman correlation analysis and Wilcoxon test were conducted to identify factors related to IOI-HA overall and subscales scores. Stepwise multiple linear regression analysis was subsequently performed to determine the influence of factors on HA outcomes. RESULTS: Age, daily use time, HA price, pure tone average (PTA) threshold, word recognition score (WRS), fitting (bilateral or unilateral), and HA style were associated with IOI-HA overall and subscales scores. However, on ly WRS, daily HA use time, HA price, and age entered the final regression model and were factors determining HA outcomes. CONCLUSIONS: HA outcome is a multi-dimensional construct. In this study, WRS had the greatest influence on HA outcomes and seemed to be a primary predictor. Thus, HA owners with a higher WRS before HA fitting may indicate better satisfaction. Daily use time, HA price, and patient age also made significant contributions to HA outcomes and should be considered in clinical practice to facilitate auditory rehabilitation. PMID:34725721 | DOI:10.1007/s00405-021-07126-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Evaluation of Size, Laterality, and Location of Unilateral Vocal Fold Lesions on Voice Quality

xlomafota13 shared this article with you from Inoreader Evaluation of Size, Laterality, and Location of Unilateral Vocal Fold Lesions on Voice Quality Via Journal of Voice The presence of a vocal fold mass implies high mechanical stress at the vocal fold base during vibration and an impaired glottic closure. However, evidence about its potential effects on diagnostic tools used in voice evaluation is lacking. We aimed to evaluate the impact of the location, laterality, and size of a unilateral unique vocal fold lesion on patient self-assessment questionnaires, acoustic-aerodynamic voice measures, and perceptual voice evaluation (GRBAS scale). View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predictive Factors Affecting the Outcomes Of angiolytic Laser-Assisted Glottoplasty for Sulcus Vocalis

xlomafota13 shared this article with you from Inoreader Predictive Factors Affecting the Outcomes Of angiolytic Laser-Assisted Glottoplasty for Sulcus Vocalis Via Journal of Voice Glottoplasty using an angiolytic laser is an option for the surgical treatment of sulcus vocalis. In this study, we sought to evaluate the clinical outcomes of using a 532-nm diode laser in sulcus vocalis patients and to identify predictive factors of improved voice outcomes after angiolytic laser-assisted glottoplasty. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A comparison of bronchial blocker under artificial pneumothorax and double-lumen endobronchial tube for lung isolation in thoracoscopic enucleation of oesophageal leiomyoma

xlomafota13 shared this article with you from Inoreader A comparison of bronchial blocker under artificial pneumothorax and double-lumen endobronchial tube for lung isolation in thoracoscopic enucleation of oesophageal leiomyoma Via Traditional dysphagia therapy J Cardiothorac Surg. 2021 Oct 31;16(1):322. doi: 10.1186/s13019-021-01707-4. ABSTRACT BACKGROUND: Oesophageal leiomyomas are one of the most common benign oesophageal tumours. This retrospective, observational study summarized and compared the clinical outcomes of thoracoscopic enucleation of oesophageal leiomyoma between single-lumen endotracheal intubation with a bronchial blocker and double-lumen endotracheal intubation. METHODS: A total of 36 patients who underwent thoracoscopic enucleation of oesophageal leiomyoma at Peking Union Medical College Hospital between 2014 and 2020 were retrospectively analysed. Fifteen patients received single-lumen endotracheal intubation combined with a right bronchial blocker (SLT-B group), and twenty-one patients received double-lumen endotracheal intubation (DLT group). Clinical data, surgical variables, and postoperative complications were analysed and compared. RESULTS: The average tumour s ize in all patients was 4.3 ± 2.0 cm. The average tumour size among symptomatic patients was significantly larger than that among asymptomatic patients (5.1 ± 2.0 cm vs 3.7 ± 1.7 cm, P < 0.05). Patients in the SLT-B group had a significantly larger average tumour size than patients in the DLT group (5.4 ± 2.1 cm vs 3.5 ± 1.4 cm, P < 0.05). The SLT-B group had a significantly shorter operation time and shorter total hospital stay than the DLT group. No mucosal injury, conversion to thoracotomy, or other operative complications occurred in the SLT-B group. In the follow-up, no recurrence, dysphagia, or regurgitation was found in any of the patients. CONCLUSIONS: Compared with traditional double-lumen intubation, artificial pneumothorax-assisted single-lumen endotracheal intubation combined with a bronchial blocker for thoracoscopic oesophageal leiomyoma enucleation can achieve complete removal of larger tumours, with fewer complications and shorter hospital stays. PMID:34719379 | DOI:10.1186/s13019-021-01707-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Adaptation to a High Iodine Intake in Greenland Inuit Suggested by Thyroid Disease Pattern

xlomafota13 shared this article with you from Inoreader Adaptation to a High Iodine Intake in Greenland Inuit Suggested by Thyroid Disease Pattern Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cutoff Age Between Pediatric and Adult Thyroid Differentiated Cancer: Is 18 Years Old Appropriate?

xlomafota13 shared this article with you from Inoreader Cutoff Age Between Pediatric and Adult Thyroid Differentiated Cancer: Is 18 Years Old Appropriate? Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of high-flow CSF leak closure with nasoseptal flap following endoscopic endonasal approach in adult and pediatric populations

xlomafota13 shared this article with you from Inoreader Comparison of high-flow CSF leak closure with nasoseptal flap following endoscopic endonasal approach in adult and pediatric populations Via leak of cerebrospinal fluid Int Forum Allergy Rhinol. 2021 Oct 30. doi: 10.1002/alr.22910. Online ahead of print. NO ABSTRACT PMID:34719119 | DOI:10.1002/alr.22910 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can prestin level be a biomarker for determining sensorineural hearing loss?

xlomafota13 shared this article with you from Inoreader Can prestin level be a biomarker for determining sensorineural hearing loss? Via Auris Nasus Larynx Publication date: Available online 31 October 2021 Source: Auris Nasus Larynx Author(s): Sadettin Emre, Turgut Karlidag, Süleyman Aydın, Irfan Kaygusuz, Erol Keles, Abdulvahap Akyigit, Sinasi Yalcin View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radiation Recall Dermatitis following Radioactive Iodine Therapy: A New Observation

xlomafota13 shared this article with you from Inoreader Radiation Recall Dermatitis following Radioactive Iodine Therapy: A New Observation Via radioactive iodine Case Rep Oncol Med. 2021 Oct 22;2021:8422748. doi: 10.1155/2021/8422748. eCollection 2021. ABSTRACT A 47-year-old female, who had previously received adjuvant right breast radiation for ductal carcinoma in situ, presented with right breast edema, erythema, and pain. This developed about two and a half weeks following radioactive iodine therapy for thyroid carcinoma. A biopsy was performed to rule out malignancy, since inflammatory breast cancer can present with similar symptoms. Th is confirmed radiation recall dermatitis (RRD) as the most likely diagnosis. RRD is an inflammatory reaction occurring in a previously irradiated field and was first described in 1959. Subsequent reports in the literature have associated it with the administration of other drugs, mostly chemotherapy. To our knowledge, this is the first reported case of RRD following radioactive iodine therapy. PMID:34721913 | PMC:PMC8556093 | DOI:10.1155/2021/8422748 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.