Syndrome d’Eagle à l’origine d’une sténose grave de la carotide interne

xlomafota13 shared this article with you from Inoreader Syndrome d'Eagle à l'origine d'une sténose grave de la carotide interne Via Laryngologie CMAJ. 2021 Oct 12;193(40):E1580-E1581. doi: 10.1503/cmaj.202803-f. NO ABSTRACT PMID:34642164 | DOI:10.1503/cmaj.202803-f View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Short-term outcomes of cochlear implantation for single-sided deafness compared to bone conduction devices and contralateral routing of sound hearing aids—Results of a Randomised controlled trial (CINGLE-trial)

xlomafota13 shared this article with you from Inoreader Short-term outcomes of cochlear implantation for single-sided deafness compared to bone conduction devices and contralateral routing of sound hearing aids—Results of a Randomised controlled trial (<i>CINGLE-trial</i>) Via Tinnitus by Jeroen P. M. Peters, Jan A. A. van Heteren, Anne W. Wendrich, Gijsbert A. van Zanten, Wilko Grolman, Robert J. Stokroos, Adriana L. Smit Single-sided deafness (SSD) leads to difficulties with speech perception in noise, sound localisation, and sometimes tinnitus. Current treatments (Contralateral Routing of Sound hearing aids (CROS) and Bone Conduction Devices (BCD)) do not sufficiently overcome these problems. Cochlear implants (CIs) may help. Our aim was to evaluate these treatments in a Randomised Controlled Trial (RCT). Adult SSD patients were randomised using a web-based randomisation tool into one of three groups: CI; trial period of 'first BCD, then CROS'; trial period of 'first CROS, then BCD'. After these trial periods, patients opted for BCD, CROS, or No treatment. The primary outcome was speech perception in noise (directed from the front (S0N0)). Secondary outcomes were speech perception in noise with speech directed to the poor ear and noise to the better ear (SpeNbe) and vice versa (SbeNpe), sound localisation, tinnitus burden, and disease-specific quality of life (QoL). We described results at baseline (unaided situation) and 3 and 6 months after device activation. 120 patients were randomised. Seven patients did not receive the allocated intervention. The number of patients per group after allocation was: CI (n = 28), BCD (n = 25), CROS (n = 34), and No treatment (n = 26). In S0N0, the CI group performed significantly better when compared to baseline, and when compared to the other groups. In SpeNbe, there was an advantage for all treatment groups compared to baseline. However, in SbeNpe, BCD and CROS groups performed worse compared to baseline, whereas the CI group improved. Only in the CI group sound localisation improved and tinnitus burden decreased. In general, all treatment groups improved on disease-specific QoL compared to baseline. This RCT demonstrates that cochlear implantation for SSD leads to improved speech perception in noise, sound localisation, tinnitus burden, and QoL after 3 and 6 months of follow-up. For most outcome measures, CI outperformed BCD and CROS. Trial registration: Netherlands Trial Register (www.trialregister.nl): NTR4580, CINGLE-trial. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Architecture of the cancellous bone in human proximal tibia based on P45 sectional plastinated specimens

xlomafota13 shared this article with you from Inoreader Architecture of the cancellous bone in human proximal tibia based on P45 sectional plastinated specimens Via radiol anat Surg Radiol Anat. 2021 Oct 12. doi: 10.1007/s00276-021-02826-2. Online ahead of print. ABSTRACT PURPOSE: To reveal differences in the pattern of trabecular architecture in the epiphysis and metaphysis of the proximal tibia. METHODS: The trabecular architecture of the proximal tibia was observed in 27 P45 plastinated knee specimens. RESULTS: In the medial and lateral condyles, under the articular cartilage surrounded by the medial or lateral meniscus, the cancellous bone is for med by thick and dense trabecular bands, which run longitudinally in the epiphysis and then pass through the epiphyseal line to terminate on the slanted cortex of the metaphysis. In the intercondylar eminence, the trabeculae are arranged basically in a network. In the central portion of the tibial metaphysis, cancellous bone consists of fine arcuate trabeculae, which extend to the anterior and posterior cortices, respectively. These trabeculae are intersected sparsely and form trusses over the medullary cavity. Near the areas of attachment of the iliotibial tract, tibial collateral ligament, anterior and posterior cruciate ligaments, and patellar ligament, the cancellous bone is locally reinforced with patchy trabeculae, dense radiating trabeculae, or two orthotropic trabecular bands. CONCLUSION: This study provides further accurate anatomical information on the trabeculae of the proximal tibia. The soft structures of knee joint, including the articular cartilage, menisci, and ligaments, and the slanted cortices of the metaphysis are important landmarks for the location of different arrangements of the cancellous architecture. The present results are beneficial for clinical diagnosis and treatment of pathologies of the knee joint, or the establishment of a finite element analysis model of the knee joint. PMID:34642771 | DOI:10.1007/s00276-021-02826-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double‐blind Phase Ib study

xlomafota13 shared this article with you from Inoreader Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double‐blind Phase Ib study Via Experimental Dermatology Abstract The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double-blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of the selective SYK inhibitor GSK2646264 in active CLE lesions. Two lesions from each participant (n = 11) were each randomized to topical application of 1% (w/w) GSK2646264 or placebo for 28 days; all participants received GSK2646264 and placebo. The primary endpoint was safety and tolerability of GSK2646264, assessed by adverse event incidence and a skin tolerability test. Secondary endpoints included change from baseline in clinical activity and mRNA expression of interferon-related genes in skin biopsies. Levels of several immune cell markers were evaluated over time. Eight (73%) participants experienced ≥ 1 adverse event (all mild in intensity), and maximal dermal response was similar for GSK2646264 an d placebo. The expression of several interferon-related genes, including CXCL10 and OAS1, showed modest decreases from baseline after 28 days of treatment with GSK2646264 compared with placebo. Similar findings were observed for CD3 + T cell and CD11c + dendritic cell levels; however, overall clinical activity remained unchanged with GSK2646264 vs. placebo. Further studies are warranted to assess SYK inhibitors as potential treatment for CLE. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multiple Dural Arteriovenous Fistulas Presenting as Objective Pulsatile Tinnitus and Evaluated Using Four-Dimensional Contrast-Enhanced MR Angiography

xlomafota13 shared this article with you from Inoreader Multiple Dural Arteriovenous Fistulas Presenting as Objective Pulsatile Tinnitus and Evaluated Using Four-Dimensional Contrast-Enhanced MR Angiography Via ear nose throat Ear Nose Throat J. 2021 Oct 13:1455613211049842. doi: 10.1177/01455613211049842. Online ahead of print. NO ABSTRACT PMID:34643457 | DOI:10.1177/01455613211049842 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A urine and serum metabolomics study of gastroesophageal reflux disease in TCM syndrome differentiation using UPLC-Q-TOF/MS

xlomafota13 shared this article with you from Inoreader A urine and serum metabolomics study of gastroesophageal reflux disease in TCM syndrome differentiation using UPLC-Q-TOF/MS Via Traditional dysphagia therapy J Pharm Biomed Anal. 2021 Nov 30;206:114369. doi: 10.1016/j.jpba.2021.114369. Epub 2021 Sep 15. ABSTRACT Gastroesophageal reflux disease (GERD) is a common, chronic and complex upper gastrointestinal disease. In Traditional Chinese medicine (TCM) theory, GERD is classified into two main types: stagnant heat of liver and stomach (SHLS) and deficient cold of spleen and stomach (DCSS). The discovery and evaluation of potential biomarkers for different syndrome types of GERD may contribute to comprehend specific molecular mechanism and identify new targets for diagnosis and appropriate management. In our study, 60 subjects including 40 GERD patients (20 SHLS and 20 DCSS) and 20 healthy controls were recruited, and the serum and urine metabolic profiles from untargeted liquid chromatography coupled to mass spectrometry (LC-MS) metabolomics approach were obtained. Finally 38 biomarkers associated with disease were identified and 9 metabolic pathway s were enriched. The most enriched pathways were amino acid metabolism, steroid hormone biosynthesis, glycerophospholipid metabolism, sphingolipid metabolism and TCA cycle. According to the area under curve (AUC) value, we propose a cohort of three metabolites from urine and serum samples as promising biomarkers for TCM syndrome differentiation of GERD, which are prolylhydroxyproline, glycitein-4'-O-glucuronide, capsianoside I in urine and neuAcalpha2-3Galbeta-Cer (d18:1/16:0), sphinganine, arachidonic acid in serum. The cumulative AUC value of merged biomarkers in urine and serum was 0.979 (95%CI 0.927-1) and 0.842 (95%CI 0.704-0.980), respectively. The results indicated that LC-MS based metabolomic profiling method might be an effective and promising tool on further pathogenesis discovering of GERD. The findings provided new strategy for the diagnosis of GERD TCM syndrome differentiation in clinic. PMID:34551376 | DOI:10.1016/j.jpba.2021.114369 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A New Anatomical Variation and Course of RLN Described: A Rare Case Report of a Lateral and Superiorly Placed Bilateral RLN Over the Thyrohyoid Muscle

xlomafota13 shared this article with you from Inoreader A New Anatomical Variation and Course of RLN Described: A Rare Case Report of a Lateral and Superiorly Placed Bilateral RLN Over the Thyrohyoid Muscle Via Otolaryngology Indian Abstract Ling XY described 3 variations of RLN in relation to Inferior thyroid artery (ITA), with the RLN either being anterior to ITA, in between the branches of ITA or posterior to ITA. We add to these variations and present a new anatomical variation and course of RLN in which it lies in a lateral position and descends from a superior position on the thyrohyoid muscle to enter the larynx medially. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Management of Allergic Fungal Rhinosinusitis Associated with Vision Loss During COVID-19 Era

xlomafota13 shared this article with you from Inoreader Management of Allergic Fungal Rhinosinusitis Associated with Vision Loss During COVID-19 Era Via Otolaryngology Indian Abstract The ongoing COVID-19 pandemic has given rise to unique challenges related to healthcare management. The problems have arisen due to the direct effect of COVID 19 infection and treatment or as repercussions of administrative efforts being undertaken to check the rapid spread of the epidemic. The management of some of the diseases has been hampered with the implementation of the policies like lockdown and transportation difficulties. This paper presents a series of four patients (6 eyes with vision loss) of an otherwise benign entity, Allergic Fungal Rhinosinusitis (AFRS), causing visual deterioration, managed amid the pandemic. AFRS has been known to cause vision loss by pressure over the optic nerve or its blood supply; however, a timely surgical intervention in the form of functional endoscopic sinus surgery to remove the disease and decompress the optic nerve, results in favourable outcomes in most patients. A delay in diagnosis and treatment may result in irre parable damage with the resulting inability to salvage the vision. In our series, we observed that vision recovery could be achieved in 66.7% of the affected eyes (four out of six eyes), while a poor visual outcome was observed in two (33%). The poor visual outcome was observed for the eyes with a prolonged visual impairment (4–6 months) at the time of presentation. We would appeal to the physicians to be cognizant of the adverse outcomes associated with the delayed surgical intervention of AFRS in the current pandemic scenario. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effect of Tinnitus in Distortion Products Otoacoustic Emissions (DPOAEs) in Normal Hearing Patients

xlomafota13 shared this article with you from Inoreader Effect of Tinnitus in Distortion Products Otoacoustic Emissions (DPOAEs) in Normal Hearing Patients Via Otolaryngology Indian Abstract Tinnitus is a symptom whose pathophysiology remains still unclear. Its diagnosis and treatment is complicated, due to its subjectivity. The generation of tinnitus is commonly linked with the impaired functioning of the outer hair cells (OHC) inside the cochlea. Distortion product otoacoustic emissions (DPOAEs) are the objective test used to assess their activity. This study investigates the cochlear outer hair cell function in patients with tinnitus and normal hearing using DPOAEs. We performed a prospective study of the cochlear function in normal hearing patients complaining of tinnitus by analysing DPOAEs amplitude and signal/noise (S/N) ratio. We gathered a sample of 21 ears from adults that attended to the ENT Department complaining of tinnitus with normal hearing. We compared their results with a control group of 21 ears, with the same demographic characteristics, presenting normal hearing but without tinnitus in order to exclude the influence of age in DPO AEs results. A decreased mean of S/N levels in DPOAEs was found in tinnitus and normal hearing group comparing with control group, although these differences were not statistically significant (p > 0.05). Based on the results, OHC dysfunction is not necessary to experience tinnitus. The majority of the patients that present OHC dysfunction do not present a tinnitus at the moment. Other mechanisms in auditory pathway may be evaluated in the tinnitus development. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acute Vocal Fold Paresis and Paralysis After COVID-19 Infection: A Case Series

xlomafota13 shared this article with you from Inoreader Acute Vocal Fold Paresis and Paralysis After COVID-19 Infection: A Case Series Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Oct 13:34894211047829. doi: 10.1177/00034894211047829. Online ahead of print. ABSTRACT OBJECTIVE: Evidence demonstrates neurotropism is a common feature of coronaviruses. In our laryngology clinics we have noted an increase in cases of "idiopathic" vocal fold paralysis and paresis in patients with no history of intubation who are recovering from the novel SARS-Cov-2 coronavirus (COVID-19). This finding is concerning for a post-viral vagal neuropathy (PVVN) a s a result of infection with COVID-19. Our objective is to raise the possibility that vocal fold paresis may be an additional neuropathic sequela of infection with COVID-19. METHODS: Retrospective review of patients who tested positive for COVID-19, had no history of intubation as a result of their infection, and subsequently presented with vocal fold paresis between May 2020 and January 2021. Charts were reviewed for demographic information, confirmation of COVID-19 infection, presenting symptoms, laryngoscopy and stroboscopy exam findings, and laryngeal electromyography (LEMG) results. RESULTS: Sixteen patients presented with new-onset dysphonia during and after recovering from a COVID-19 infection and were found to have unilateral or bilateral vocal fold paresis or paralysis. LEMG was performed in 25% of patients and confirmed the diagnosis of neuropathy in these cases. CONCLUSIONS: We believe that COVID-19 can cause a PVVN resulting in abnormal vocal fold mobil ity. This diagnosis should be included in the constellation of morbidities that can result from COVID-19 as the otolaryngologist can identify this entity through careful history and examination. PMID:34643462 | DOI:10.1177/00034894211047829 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Epistaxis-overview and current aspects

xlomafota13 shared this article with you from Inoreader Epistaxis-overview and current aspects Via hno HNO. 2021 Oct 13. doi: 10.1007/s00106-021-01110-4. Online ahead of print. ABSTRACT Nosebleeds (epistaxis) are usually minor. Medical intervention is only necessary in about 6% of cases. The source of bleeding is frequently located in the anterior region of the nose (Kiesselbach's plexus). The estimated lifetime prevalence of epistaxis is 60%. Diffuse epistaxis is often a manifestation of systemic disease. Epistaxis is the leading symptom of Rendu-Osler-Weber disease (hereditary hemorrhagi c telangiectasia, HHT). If intervention is required, the first-choice of treatment is bidigital compression for several minutes. Common therapeutic measures include local hemostasis using electrocoagulation or chemical agents, e.g., silver nitrate. Resorbable anterior nasal tampons or tampons with a smooth surface are also frequently employed. In case of failed surgical closure of the sphenopalatine artery, angiographic embolization is the method of choice. PMID:34643746 | DOI:10.1007/s00106-021-01110-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.