06:45
Abstract Aim (s)Ciprofloxacin and fluconazole combination therapy is frequently used as prophylaxis for and treatment of infections in patients with haematological malignancies. However, both drugs are known to prolong the QTc-interval, which is a serious risk factor for Torsade de Pointes (TdP). Therefore,...
04:46
SUMMARY AimsOral systemic corticosteroids have been used to induce remission in patients with active inflammatory bowel disease (IBD) for over 50 years; however, the wide array of adverse events (AEs) associated with these drugs prompted the development of steroid compounds with targeted delivery and...
Sun Oct 22, 2017 22:15
Publication date: Available online 21 October 2017Source:Brachytherapy Author(s): John Weaver, Grant Harmon, Matthew M. Harkenrider, Murat Surucu, Abbie Wood, Fiori Alite, William SmallPurposeTo define the relationship between the Point A prescription dose and the dose delivered to...
Sun Oct 22, 2017 01:30
To perform a systematic review regarding the use of stereotactic ablative radiotherapy (SABR) for the re-irradiation of recurrent malignant disease within the pelvis, to guide the clinical implementation of this technique. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/2zspsVd via IFTTT
Sat Oct 21, 2017 23:26
Summary What is known and objectiveAspirin therapy is the clinical gold standard for the prevention of cardiovascular events. However, cardiovascular events still develop in some patients undergoing aspirin therapy. Many laboratory methods exist for measuring aspirin resistance. Using the platelet...
Sat Oct 21, 2017 22:55
Publication date: November–December 2017Source:Reports of Practical Oncology & Radiotherapy, Volume 22, Issue 6 Author(s): Ravindra Shende, Ganesh PatelAimObjective of present study is to determine optimum value of DLG and its validation prior to being incorporated in TPS for Varian TrueBeam™...
Sat Oct 21, 2017 20:51
[Posted 10/21/2017] AUDIENCE: Pharmacy, Health Professional ISSUE: SCA Pharmaceuticals LLC (“SCA Pharmaceuticals”) is voluntarily recalling various lots of injectable products to the hospital level. The is a potential for the products to… from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2yEQHhr...
Sat Oct 21, 2017 17:16
To determine the areas of potential geographic error in adjuvant radiotherapy (RT) for biliary-tract cancer (BTC) by comparing pathological-surgical data on the pattern of nodal spread with the extent of elective nodal CTV used in published RT studies in this setting. from Therapeutics via xlomafota13...
Sat Oct 21, 2017 17:16
Our aim was to evaluate the feasibility and potential advantages of dose guided patient positioning based on dose recalculation on scatter corrected cone beam computed tomography (CBCT) image data. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2l59u0L via IFTTT
Sat Oct 21, 2017 14:10
. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2yyI09q via IFTTT
Sat Oct 21, 2017 14:10
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Sat Oct 21, 2017 06:22
The Hippo pathway has generated considerable interest in recent years because of its involvement in several key hallmarks of cancer progression and metastasis. Research on the Hippo signaling pathway in cancer has been used to determine the activity of yes-associated protein (YAP) in tumorigenesis and...
Sat Oct 21, 2017 06:22
Polymer prodrugs can considerably improve the treatment of tumors with multidrug resistance, often caused by overexpression of P-glycoprotein (P-gp). Here, we present the effect of the N-(2-hydroxypropyl) methacrylamide-based polymer conjugate with P-gp inhibitor ritonavir (RIT) on the increase of free...
Sat Oct 21, 2017 06:22
This prospective, noninterventional study is the first phase IV trial designed to evaluate trabectedin in patients with advanced soft tissue sarcoma in real-life clinical practice across Europe. To be included in the study, patients must have received more than or equal to one cycle of trabectedin and...
Sat Oct 21, 2017 06:22
Promising clinical efficacy has been observed with receptor tyrosine kinase inhibitors (TKIs) particularly in lung and gastric cancers with mutations or amplifications in the targeted receptor tyrosine kinases (RTKs). However, the efficacy and the duration of the response to these inhibitors are limited...
Sat Oct 21, 2017 06:22
Liposomal irinotecan (irinotecan liposome injection, nal-IRI), a liposomal formulation of irinotecan, is designed for extended circulation relative to irinotecan and for exploiting discontinuous tumor vasculature for enhanced drug delivery to tumors. Following tumor deposition, nal-IRI is taken up by...
Sat Oct 21, 2017 06:22
MicroRNAs (miRNAs) have been reported to be associated with cancer progression and carcinogenesis. They are small, highly conserved, noncoding RNA molecules consisting of 19–25 nucleotides. By binding to complementary binding sites within the 3′-untranslated region of target mRNAs, miRNAs inhibit the...
Sat Oct 21, 2017 06:22
N1-guanyl-1,7-diaminoheptane (GC7), a deoxyhypusine synthase inhibitor, has been shown to exert antiproliferation effects in many solid tumors by regulating eukaryotic translation initiation factor 5a2 (eif5a-2). However, little is known about the role of GC7 and eif5a-2 in drug resistance in acute lymphoblastic...
Sat Oct 21, 2017 06:22
Cancer cells have an increased requirement for iron than normal cells, and iron chelators are under active consideration for cancer treatment. The metal-sequestering potential and antiproliferative mechanisms of a novel hydroxyphenyl hydrazone derivate YCL0426 were investigated here. Antiproliferative...
Sat Oct 21, 2017 06:22
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is often overexpressed in rhabdomyosarcoma (RMS). However, its oncogenic and functional role in RMS remains unclear. Therefore, we investigated the antitumor activity of LDK378 (ceritinib), a new second-generation ALK inhibitor approved...
Sat Oct 21, 2017 06:22
Nonmelanoma skin cancer is the most common cancer in humans, comprising mainly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC proliferation is highly dependent on the Hedgehog signaling pathway. We aimed to investigate a panel of anticancer drugs with known activity against skin cancer...
Sat Oct 21, 2017 06:22
Gallic acid (GA) possesses potential antitumoral activity on different types of malignancies. In this study, we aimed to explore the antitumoral effects of GA on triple-negative breast cancer (TNBC) cells, the breast cancer cells showing resistance to hormonal therapy or HER2 receptor targeting therapy....
Sat Oct 21, 2017 06:22
A close correlation between early tumor shrinkage (ETS) and overall survival (OS) has been shown in antiepidermal growth factor receptor antibody-based chemotherapies for metastatic colorectal cancer (mCRC), but the clinical impact of ETS in bevacizumab-based chemotherapy has not been adequately clarified....
Sat Oct 21, 2017 02:17
Preclinical and clinical data suggest that the chemokine pathway governed by SDF-1 and CXCR4 contributes to a resistant phenotype. This retrospective biomarker study aims to explore the specific prognostic value of SDF-1 and CXCR4 expression in locally advanced head and neck squamous cell carcinomas...
Sat Oct 21, 2017 02:17
To prospectively investigate the use of an independent DVH prediction tool to detect outliers in the quality of fully automatically generated treatment plans for prostate cancer patients. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/2xUr48N via IFTTT
Sat Oct 21, 2017 01:47
Publication date: Available online 20 October 2017Source:Journal of Environmental Radioactivity Author(s): M. Villa-Alfageme, E. Chamizo, F.J. Santos-Arévalo, J.M. López-Gutierrez, I. Gómez-Martínez, S. Hurtado-BermúdezThere are very few data available of 236U in marine sediment cores....
Fri Oct 20, 2017 20:38
Abstract Recommendations and guidelines for the collection, generation, source and usage of utility data for health technology assessment (HTA) vary across different countries, with no international consensus. Many international agencies generate their own guidelines providing details...
Fri Oct 20, 2017 20:38
Abstract Systematic literature reviews of health-related quality of life (HRQoL) evidence that are to inform economic models can be challenging due to the volume of hits identified in searches using generic terms for HRQoL. Nevertheless, a robust review of the literature is required...
Fri Oct 20, 2017 20:38
Abstract A comorbidity is defined as the presence of at least one additional health condition co-occurring with a primary health condition. Decision analytic models in healthcare depict the typical clinical pathway of patients in general clinical practice and frequently include health...
Fri Oct 20, 2017 20:38
Abstract A conceptual model framework and an initial literature review are invaluable when considering what health state utility values (HSUVs) are required to populate health states in decision models. They are the recommended starting point early within a research and development...
Fri Oct 20, 2017 20:38
Abstract Mapping functions are estimated using regression analyses and are frequently used to predict health state utility values (HSUVs) in decision analytic models. Mapping functions are used when evidence on the required preference-based measure (PBM) is not available, or where...
Fri Oct 20, 2017 20:38
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Fri Oct 20, 2017 20:38
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Fri Oct 20, 2017 20:38
Abstract Generic preference-based measures (GPBMs) of health are used to obtain the quality adjustment weight required to calculate the quality-adjusted life year in health economic models. GPBMs have been developed to use across different interventions and medical conditions and...
Fri Oct 20, 2017 20:38
Abstract A condition-specific preference-based measure (CSPBM) is a measure of health-related quality of life (HRQOL) that is specific to a certain condition or disease and that can be used to obtain the quality adjustment weight of the quality-adjusted life-year (QALY) for use in...
Fri Oct 20, 2017 20:38
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Fri Oct 20, 2017 20:38
Abstract Methodological issues of how to use health state utility values (HSUVs) in decision models arise frequently, including the most appropriate evidence to use as the baseline (e.g. the baseline HSUVs associated with avoiding a particular health condition or event), how to...
Fri Oct 20, 2017 14:26
Abstract Colorectal cancer (CRC) is the third most common solid internal malignancy among cancers. Early detection of cancer is key to increasing the survival rate of colorectal cancer patients. Overexpression of the EGFR protein is associated with CRC. We have designed a series of peptides that are...
Fri Oct 20, 2017 14:26
Abstract Although various delivery systems for nucleic acids have been reported, development of an efficient and non-toxic delivery carrier is still a key subject for gene therapy. In order to find new efficient delivery carriers for nucleic acids, we synthesized amphiphilic peptides composed of a...
Fri Oct 20, 2017 14:26
Abstract Estrogen receptor (ER) has been a therapeutic target to treat ER positive breast cancer, most notably by agents known as selective estrogen receptor modulators (SERMs). However, resistance and severe adverse effects of known drugs gave impetus to the search for newer agents with better therapeutic...
Fri Oct 20, 2017 14:26
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Fri Oct 20, 2017 13:25
Abstract A series of scopoletin derivatives were designed and synthesized by introducing α-aminoacetamide, acrylamide and β-aminopropamide respectively to 3-position of scopoletin and their chemical structures were confirmed by ESI-MS, IR, 1H NMR and 13C NMR spectra. All target compounds were evaluated...
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Kuipers and Pittayanon et al papers. To view these articles visit http://ift.tt/2yUsjK4 and http://ift.tt/2hRCyUE. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2yVuhds via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Costa et al papers. To view these articles visit http://ift.tt/2yVVoET and http://ift.tt/2yVuiOy. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hRCxQA via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Kang et al papers. To view these articles visit http://ift.tt/2yWgBPh and http://ift.tt/2yVsrsR. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hRCvYY via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Le et al papers. To view these articles visit http://ift.tt/2hS2uzF and http://ift.tt/2yWgy63. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hQW5EB via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Kwon and Jeon, and Kwon et al papers. To view these article visit http://ift.tt/2yVugWW and http://ift.tt/2hTo1aO from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hRKPIa via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Tau and Papas, and Le et al papers. To view these articles visit http://ift.tt/2yUQWGt and http://ift.tt/2yWgy63. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hRCeFq via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Dai et al and Swaminath et al papers. To view these articles visit http://ift.tt/2yVBcmC and http://ift.tt/2hQKlSI. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hSC4NZ via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Fock and Ang, and Kwon et al papers. To view these articles visit http://ift.tt/2yWPkMF and http://ift.tt/2hTo1aO. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2yWgx1Z via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Huang and Kang et al papers. To view these articles visit http://ift.tt/2hQ6sJ1 and http://ift.tt/2yVsrsR. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hScMzp via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Strik et al paper. To view this article visit http://ift.tt/2hS2tf5. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2yUQV5n via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Feathers et al and Swaminath et al papers. To view these articles visit http://ift.tt/2yWGGxI and http://ift.tt/2hQKlSI. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2yWGONI via IFTTT
Fri Oct 20, 2017 13:25
Linked Content This article is linked to Uno and Costa et al papers. To view these articles visit http://ift.tt/2hSxsr5 and http://ift.tt/2yVVoET. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2hRLIR3 via IFTTT
Fri Oct 20, 2017 13:25
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Fri Oct 20, 2017 12:24
Summary BackgroundFaecal microbiota transplantation is an experimental approach for the treatment of patients with ulcerative colitis. Although there is growing evidence that faecal microbiota transplantation is effective in this disease, factors affecting its response are unknown. AimsTo establish...
Fri Oct 20, 2017 12:24
Summary BackgroundSmoking is a strong environmental factor leading to adverse outcomes in Crohn’s disease, but a more benign course in ulcerative colitis. Several single nucleotide polymorphisms (SNPs) are associated with smoking quantity and behaviour. AimsTo assess whether smoking-associated SNPs...
Fri Oct 20, 2017 03:43
Irradiating glioblastoma preoperative edema (PE) remains controversial. We investigated the associations between tumors’ PE extent with invasion into synchronous subventricular zone and corpus callosum (sSVZCC) and treatment outcomes to provide the clinical evidence for radiotherapy decision-making....
Fri Oct 20, 2017 03:43
Publication date: Available online 19 October 2017Source:Journal of Bodywork and Movement Therapies Author(s): Jerin Mathew, Kavitha Raja, Febin P. Baby, B. BasimaBackgroundIn most developing countries, accessibility for people using walking aids is limited due to architectural and environmental...
Fri Oct 20, 2017 02:12
Abstract Background Pazopanib is an angiogenesis inhibitor approved for the treatment of renal cell carcinoma and soft tissue sarcoma. Post hoc analysis of a clinical trial demonstrated a relationship between pazopanib trough concentrations...
Fri Oct 20, 2017 01:11
Publication date: Available online 19 October 2017Source:Journal of Environmental Radioactivity Author(s): T. Wilflinger, H. Lettner, A. Hubmer, P. Bossew, B. Sattler, H. SlupetzkyCryoconites (“cold dust”, derived from the Greek) are aeolian sediments accumulated on glacier surfaces....
Fri Oct 20, 2017 00:11
Multiple myeloma (MM) is a hematological malignancy that is characterized by the clonal expansion of plasma cells in the bone marrow. Histone deacetylases (HDACs) represent a new type of molecular targeted therapy for different types of cancers and promising targets for myeloma therapy. We showed that...
Fri Oct 20, 2017 00:11
Abstract In primary hyperparathyroidism (PHPT), bone loss results from the resorptive effects of excess parathyroid hormone (PTH). Under physiological conditions, PTH has actions that are more targeted to homeostasis and to bone accrual. The predominant action of PTH, either catabolic, anabolic, or...
Fri Oct 20, 2017 00:11
Abstract Objective The aim of this study was to investigate the safety, maximum tolerated dose and pharmacokinetics (PK) of iguratimod and the effect of food on PK parameters in healthy adult volunteers. ...
Fri Oct 20, 2017 00:11
Abstract Introduction Few studies have reported the physical complications among Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. Objective ...
Fri Oct 20, 2017 00:11
Abstract Attention-deficit/hyperactivity disorder (ADHD) is defined as a disorder of impaired attention and/or behavioral control. Studies suggest that the condition can dispose individuals to a higher risk of automobile accidents. ADHD symptoms respond to pharmacotherapy in a majority...
Thu Oct 19, 2017 22:37
Abstract Introduction Metastatic neuroendocrine tumors (NETs) are associated with carcinoid syndrome that is typically characterized by diarrhea, cutaneous flushing and bronchospasm. Treatment with somatostatin analogues (SSA) improves...
Thu Oct 19, 2017 22:37
Abstract Purpose Sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease, has been described following treatment of acute lymphoblastic leukemia (ALL) with the anti-metabolite 6-thioguanine (6-TG). Previous studies incorporating...
Thu Oct 19, 2017 22:37
Abstract Background Medication reviews intended to identify drug-related problems (DRPs) have been researched in primary care, acute care and nursing homes rather than in long-term care hospitals (LTCHs). Objectives To assess the clinical impact of an...
Thu Oct 19, 2017 22:37
Abstract Background Studies have highlighted the benefits of having community pharmacists to deliver cardiovascular screening to patients. However, only few of such trainings are provided in Malaysia. Objective To describe the implementation and evaluation...
Thu Oct 19, 2017 22:37
Abstract Background A key element for an effective and safe oral anticoagulant treatment (OAT) is to have the relevant information delivered to patients in an easy-to-understand way and thus have them apply this knowledge in their own therapy. Objective...
Thu Oct 19, 2017 19:32
Publication date: Available online 18 October 2017Source:Advanced Drug Delivery Reviews Author(s): Gustav Steinhoff, Julia Nesteruk, Markus Wolfien, Jana Große, Ulrike Ruch, Praveen Vasudevan, Paula MüllerAfter two decades of intensive research and attempts of clinical translation,...
Thu Oct 19, 2017 09:16
Summary Background Both MET and c-SRC are important mediators of cancer progression and there is cross talk between the two molecules. Preclinical studies have demonstrated combination of MET and c-SRC inhibitors is effective in multiple cancer types....
Thu Oct 19, 2017 05:41
Résumé Le syndrome de l’intestin irritable (SII) est une affection fréquente dont la prévalence moyenne est estimée à 10 %. C’est une affection chronique récurrente qui échappe souvent aux traitements conventionnels en raison de sa physiopathologie complexe et multifactorielle. Dans...
Thu Oct 19, 2017 01:06
Abstract Purpose The study aimed to fill existing knowledge gaps on the safety of antidepressant drugs (ADs) by estimating the risk of hospitalization for arrhythmia associated with use of selective serotonin reuptake inhibitors (SSRIs)...
Wed Oct 18, 2017 19:59
Publication date: Available online 18 October 2017Source:Advanced Drug Delivery Reviews Author(s): Brigitte Städler, Alexander N. Zelikin from Therapeutics via xlomafota13 on Inoreader http://ift.tt/2zygzKo via IFTTT
Wed Oct 18, 2017 19:59
Abstract The aim of this study was to develop a population pharmacodynamic (PPD) model to describe uric acid (UA)–lowering effects in patients treated with febuxostat based on electronic medical records in 2 independent hospitals (university and city hospitals). Interhospital differences in the PPD...
Wed Oct 18, 2017 15:24
Abstract Backgroundthere are no specific criteria for a step-down or withdrawal dose of omalizumab. Our purpose was to evaluate the viability of a protocol for OMAlizumab DOse REduction (the OMADORE study) in severe allergic asthma (SAA). Methodsthe study population included 35 SAA patients treated...
Wed Oct 18, 2017 15:24
Aims: To evaluate the effectiveness of nivolumab as second-line treatment compared to standard therapy with docetaxel in adult patients with non-small cell lung cancer (NSCLC) in clinical practice. Methods: This is an observational, retrospective cohort study of adult patients diagnosed with NSCLC, stage...
Wed Oct 18, 2017 09:48
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Wed Oct 18, 2017 09:48
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Wed Oct 18, 2017 09:48
Summary BackgroundThe economic impact of extrahepatic manifestations of hepatitis C virus (HCV) infection remains unknown for France. AimTo estimate the prevalence of extrahepatic manifestations of HCV and the direct medical costs associated with them. MethodsEstimates of 13 extrahepatic manifestations...
Wed Oct 18, 2017 09:18
Summary AIMThe present study evaluates the effect of antenatal lamotrigine exposure, on short and long term pediatric outcome. METHODSThe study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical center between 2004-2014. All newborns were...
Wed Oct 18, 2017 02:41
Abstract Purpose We aimed to determine whether polymorphisms in CYP3A genes may affect the risk of acute rejection episodes (ARE) in renal transplant recipients treated with calcineurin inhibitors (CNIs). ...
Wed Oct 18, 2017 02:11
Dose distributions delivered at Gantry 2 at the Paul Scherrer Institut (PSI) can be reconstructed on the patient anatomy based on machine log files. With the present work, the dependency of the log file calculation on the planning optimization technique and on other planning parameters, such as field...
Wed Oct 18, 2017 02:11
The role of concurrent chemoradiotherapy (CRT) for anaplastic gliomas is undefined and patterns of care are under-reported. To address the knowledge gap, we examined use of CRT for grade III gliomas compared to radiotherapy (RT) alone. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/2x3VQfM...
Wed Oct 18, 2017 02:11
The purpose of this study was to evaluate the safety and efficacy of PET and MRI guided re-irradiation of recurrent high-grade glioma (HGG) and to assess the impact of radiotherapy dose, fractionation and irradiated volume. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/2yttcGC via IFTTT
Wed Oct 18, 2017 02:11
We hypothesized that a plan’s robustness to anatomical changes can be improved by optimizing with multiple CT scans of a patient. The purpose of this study was to determine whether an intensity modulated proton therapy (IMPT) plan could be developed to meet dose criteria on both planning and adaptive...
Wed Oct 18, 2017 02:11
The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of cells with damaged or incompletely replicated DNA into mitosis when the cells are challenged by DNA damaging agents, such as...
Wed Oct 18, 2017 02:11
To examine the relationship between radiation dose and tumor control in limited stage non-small cell lung cancer (NSCLC). from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/2ytsF7x via IFTTT
Wed Oct 18, 2017 02:11
Publication date: Available online 17 October 2017Source:Journal of Environmental Radioactivity Author(s): Weihua Zhang, Baki Sadi, Christopher Rinaldo, Jing Chen, Norman Spencer, Kurt UngarIn this study, the activity concentrations of 210Pb and 210Po on the 22 daily air filter samples,...
