Related ArticlesCytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms. J Ethnopharmacol. 2019 Jun 29;:112049 Authors: Abdelfatah S, Lu X, Schmeda-Hirschmann G, Efferth T Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Rhinella schneideri and Rhinella marina are toad venoms distributed in different parts of the world, including Brazil, Columbia and amazon. Venoms extracted from different species have many clinical applications...
Related ArticlesCucurbitacin IIa interferes with EGFR-MAPK signaling pathway leads to proliferation inhibition in A549 cells. Food Chem Toxicol. 2019 Jun 29;:110654 Authors: Zhang J, Song Y, Liang Y, Zou H, Zuo P, Yan M, Jing S, Li T, Wang Y, Li D, Zhang T, Wei Z Abstract Cucurbitacin IIa (CuIIa), a tetracyclic triterpenoid harboring anticancer activity, was investigated in A549 cells to reveal its mechanism of targeting on epidermal growth factor receptor...
Related ArticlesDC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis. Dev Biol. 2019 Jun 29;: Authors: Tang C, van den Bijgaart RJE, Looman MWG, Tel-Karthaus N, de Graaf AMA, Gilfillan S, Colonna M, Ansems M, Adema GJ Abstract Mammary glands are unique organs in which major adaptive changes occur in morphogenesis and development after birth. Breast cancer is the most common cancer and a major cause of mortality in females...
Related ArticlesPreparation of quercetin loaded microparticles and their evaluation for antitumor activity against A549. Curr Pharm Biotechnol. 2019 Jun 28;: Authors: Li C, Gao L, Zhang Y, Simpson BK Abstract Novel quercetin-loaded microparticles (QM) were fabricated using coaxial electrospraying, characterized for surface morphology and release profile, and evaluated for antitumor activity in vitro. QM exhibited an average diameter of 1.69 ±1.13 μm,...
Related ArticlesPalbociclib, a selective CDK4/6 inhibitor, restricts cell survival and epithelial-mesenchymal transition in Panc-1 and MiaPaCa-2 pancreatic cancer cells. J Cell Biochem. 2019 Jul 01;: Authors: Rencuzogulları O, Yerlikaya PO, Gürkan AÇ, Arısan ED, Telci D Abstract The mortality rate of pancreatic cancer has close parallels to its incidence rate because of limited therapeutics and lack of effective prognosis. Despite various novel chemotherapeutics...
Related ArticlesFactors, mechanisms and implications of chromatin condensation and chromosomal structural maintenance through the cell cycle. J Cell Physiol. 2019 Jul 02;: Authors: Ravi M, Ramanathan S, Krishna K Abstract A series of well-orchestrated events help in the chromatin condensation and the formation of chromosomes. Apart from the formation of chromosomes, maintenance of their structure is important, especially for the cell division. The structural...
Related ArticlesC8-Substituted Imidazotetrazine Analogs Overcome Temozolomide Resistance by Inducing DNA Adducts and DNA Damage. Front Oncol. 2019;9:485 Authors: Yang Z, Wei D, Dai X, Stevens MFG, Bradshaw TD, Luo Y, Zhang J Abstract Temozolomide (TMZ) is the standard of care chemotherapeutic agent used in the treatment of glioblastoma multiforme. Cytotoxic O6-methylguaine lesions formed by TMZ are repaired by O6-methyl-guanine DNA methyltransferase...
Related ArticlesInhibition of Prostate Cancer Cells by 4,5-Dicaffeoylquinic Acid through Cell Cycle Arrest. Prostate Cancer. 2019;2019:4520645 Authors: Lodise O, Patil K, Karshenboym I, Prombo S, Chukwueke C, Pai SB Abstract Prostate cancer is a major cause of cancer-related mortality in men. Even though current therapeutic management has contributed to reducing mortality, additional intervention strategies are warranted to further improve the outcomes....
Related ArticlesDevelopment of a novel method for the purification of C-phycocyanin pigment from a local cyanobacterial strain Limnothrix sp. NS01 and evaluation of its anticancer properties. Sci Rep. 2019 Jul 01;9(1):9474 Authors: Safaei M, Maleki H, Soleimanpour H, Norouzy A, Zahiri HS, Vali H, Noghabi KA Abstract C-phycocyanin (C-PC) pigment, as a natural blue dye, has particular applications in various fields. It is a water-soluble protein which...
Related ArticlesIntensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects. Sci Rep. 2019 Jul 01;9(1):9483 Authors: Matsuya Y, McMahon SJ, Ghita M, Yoshii Y, Sato T, Date H, Prise KM Abstract In advanced radiotherapy, intensity modulated radiation fields and complex dose-delivery are utilized to prescribe higher doses to tumours. Here, we investigated the impact of modulated radiation fields on radio-sensitivity...
Related ArticlesIn Vitro Evaluation of Apoptotic Induction of Butyric Acid Derivatives in Colorectal Carcinoma Cells. Anticancer Res. 2019 Jul;39(7):3795-3801 Authors: Pattayil L, Balakrishnan-Saraswathi HT Abstract BACKGROUND/AIM: Butyric acid, a short chain fatty acid, plays an important role in the prevention of colon cancer. The aim of this study was to analyze the growth inhibitory and apoptotic effect of butyric acid derivatives in colorectal cancer...
Related ArticlesThe Ethanol Crude Extraction of Cyperus Rotundus Regulates Apoptosis-associated Gene Expression in HeLa Human Cervical Carcinoma Cells In Vitro. Anticancer Res. 2019 Jul;39(7):3697-3709 Authors: Lin CH, Peng SF, Chueh FS, Cheng ZY, Kuo CL, Chung JG Abstract BACKGROUND/AIM: Cervical cancer is considered poorly chemo-sensitive in women and its treatment remains unsatisfactory. Cyperus rotundus is used in Chinese medicine as a therapeutic...
Related ArticlesSelective Wnt/β-catenin Small-molecule Inhibitor CWP232228 Impairs Tumor Growth of Colon Cancer. Anticancer Res. 2019 Jul;39(7):3661-3667 Authors: Kim JY, Park G, Krishnan M, Ha E, Chun KS Abstract BACKGROUND/AIM: To explore the possibility of a selective small-molecule β-catenin inhibitor, CWP232228, as a potential therapeutic drug in the treatment of colorectal cancer (CRC). MATERIALS AND METHODS: The effect of CWP2228 on HCT116...
Related ArticlesBiochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells In Vitro. Anticancer Res. 2019 Jul;39(7):3433-3442 Authors: Fröbom R, Sellberg F, Xu C, Zhao A, Larsson C, Lui WO, Nilsson IL, Berglund E, Bränström R Abstract BACKGROUND/AIM: DOG1 is a calcium-activated chloride channel that has gained attention as a promising drug target due to its involvement in several processes essential...
Related ArticlesA kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy. Breast Cancer Res. 2019 Jul 01;21(1):77 Authors: McLaughlin RP, He J, van der Noord VE, Redel J, Foekens JA, Martens JWM, Smid M, Zhang Y, van de Water B Abstract BACKGROUND: The effective treatment of triple-negative breast cancer (TNBC) remains a profound clinical challenge. Despite frequent epidermal...
Related ArticlesThe dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens. J Exp Clin Cancer Res. 2019 Jul 01;38(1):282 Authors: Wu YY, Wu HC, Wu JE, Huang KY, Yang SC, Chen SX, Tsao CJ, Hsu KF, Chen YL, Hong TM Abstract BACKGROUND: Lung cancer is the most common cause of cancer-related mortality worldwide despite diagnostic improvements and the development...
Related ArticlesThe Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro. Cancers (Basel). 2019 Jun 30;11(7): Authors: Verhees F, Legemaate D, Demers I, Jacobs R, Haakma WE, Rousch M, Kremer B, Speel EJ Abstract Cidofovir (CDV) is an antiviral agent with antiproliferative properties. The aim of our study was to investigate the efficacy of CDV in HPV-positive...
Related ArticlesA Comparative Study of the Anticancer Activity and PARP-1 Inhibiting Effect of Benzofuran-Pyrazole Scaffold and Its Nano-Sized Particles in Human Breast Cancer Cells. Molecules. 2019 Jun 29;24(13): Authors: Anwar MM, Abd El-Karim SS, Mahmoud AH, Amr AEE, Al-Omar MA Abstract Breast cancer is considered the most common and deadly cancer among women worldwide. Nanomedicine has become extremely attractive in the field of cancer treatment....
Related ArticlesTelmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo. Int J Mol Sci. 2019 Jun 29;20(13): Authors: Matsui T, Chiyo T, Kobara H, Fujihara S, Fujita K, Namima D, Nakahara M, Kobayashi N, Nishiyama N, Yachida T, Morishita A, Iwama H, Masaki T Abstract Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan,...
Related ArticlesThe Antiproliferative and Apoptotic Effects of Capsaicin on an Oral Squamous Cancer Cell Line of Asian Origin, ORL-48. Medicina (Kaunas). 2019 Jun 28;55(7): Authors: Kamaruddin MF, Hossain MZ, Mohamed Alabsi A, Mohd Bakri M Abstract Background and Objectives: The antitumor activities of capsaicin on various types of cancer cell lines have been reported but the effect of capsaicin on oral cancer, which is prevalent among Asians, are very...
Related ArticlesYTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. Cell Cycle. 2017;16(23):2259-2271 Authors: Chen J, Sun Y, Xu X, Wang D, He J, Zhou H, Lu Y, Zeng J, Du F, Gong A, Xu M Abstract Recent studies show that YTH domain family 2 (YTHDF2) preferentially binds to m6A-containing mRNA regulates localization and stability of the bound mRNA. However, the role of YTHDF2 in pancreatic...
Related ArticlesmiR-638 Inhibits immature Sertoli cell growth by indirectly inactivating PI3K/AKT pathway via SPAG1 gene. Cell Cycle. 2017;16(23):2290-2300 Authors: Hu P, Guan K, Feng Y, Ma C, Song H, Li Y, Xia X, Li J, Li F Abstract Numerous studies have demonstrated that microRNAs (miRNAs) play important roles in cell growth, apoptosis and spermatogenesis. Our previous study showed that miR-638 was differentially expressed in sexually immature and...
Related ArticlesTFPI2AS1, a novel lncRNA that inhibits cell proliferation and migration in lung cancer. Cell Cycle. 2017;16(23):2249-2258 Authors: Gao S, Lin Z, Li C, Wang Y, Yang L, Zou B, Chen J, Li J, Song Z, Liu G Abstract Accumulating evidence demonstrates that a series of differentially expressed lncRNAs is important in tumorigenesis. However, the function of many of the lncRNAs in lung cancer remains elusive. In the present study, we used microarray...
Related ArticlesLPS-induced inflammatory response triggers cell cycle reactivation in murine neuronal cells through retinoblastoma proteins induction. Cell Cycle. 2017;16(24):2330-2336 Authors: D'Angelo B, Astarita C, Boffo S, Massaro-Giordano M, Antonella Ianuzzi C, Caporaso A, Macaluso M, Giordano A Abstract Cell cycle reactivation in adult neurons is an early hallmark of neurodegeneration. The lipopolysaccharide (LPS) is a well-known pro-inflammatory...
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Related ArticlesLack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice. Front Neurosci. 2019;13:620 Authors: Kaur T, Clayman AC, Nash AJ, Schrader AD, Warchol ME, Ohlemiller KK Abstract Noise trauma causes loss of synaptic connections between cochlear inner hair cells (IHCs) and the spiral ganglion neurons (SGNs). Such synaptic loss can trigger slow and progressive degeneration...
Related ArticlesMicrostates as Disease and Progression Markers in Patients With Mild Cognitive Impairment. Front Neurosci. 2019;13:563 Authors: Musaeus CS, Nielsen MS, Høgh P Abstract Network dysfunction is well established in patients with Alzheimer's disease (AD) and has been shown to be present early in the disease. This is especially interesting in patients with mild cognitive impairment (MCI) since they are more likely to develop AD. In EEG, one...
Related ArticlesThe Central Autonomic Network and Regulation of Bladder Function. Front Neurosci. 2019;13:535 Authors: Roy HA, Green AL Abstract The autonomic nervous system (ANS) is involved in the regulation of physiologic and homeostatic parameters relating particularly to the visceral organs and the co-ordination of physiological responses to threat. Blood pressure and heart rate, respiration, pupillomotor reactivity, sexual function, gastrointestinal...
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Acute and sub-acute toxicity evaluation of the root extract of Rheum turkestanicum Janisch. Drug Chem Toxicol. 2019 Jul 02;:1-7 Authors: Jahani Yazdi A, Javanshir S, Soukhtanloo M, Jalili-Nik M, Jafarian AH, Iranshahi M, Hasanpour M, Khatami SM, Hosseini A, Amiri MS, Ghorbani A Abstract Despite the widespread use of Rheum turkestanicum in herbal medicine, no study has yet examined its in vivo toxicity. The aim of this study is to evaluate the acute and...
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Related ArticlesHip Arthroscopy as Part of a Salvage Procedure for Avascular Necrosis (AVN) in a 7-Year-Old Child. Am J Case Rep. 2019 Jul 02;20:941-947 Authors: Delniotis I, Leidinger B Abstract BACKGROUND Avascular necrosis of the femoral head (AVN) is one of the most serious complications following developmental dysplasia of the hip (DDH). Treatment options focus mainly on improving the biomechanics and kinematics of the affected hip joint. In the...
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Related ArticlesTraumatic arteriovenous fistula between the extracranial middle meningeal artery and the petrosal vein: a case report. World Neurosurg. 2019 Jun 29;: Authors: Fei X, Ting W, Jianqiang H, Changwei Z, Richard SA, Yanhui L Abstract INTRODUCTION: The incidence of traumatic arteriovenous fistula (TAVF) between the middle meningeal artery (MMA) and the petrosal vein is very rare. Although TAVF has been reported involving the MMA several sinus...
Related ArticlesThe degree of middle and lower clivus invasion by chordoma is linked to patient prognosis via Ki-67 value. World Neurosurg. 2019 Jun 29;: Authors: Jin Z, Li L, Yu P, Bao Y, Wang Y, Li Z, Wang Y Abstract OBJECTIVES: The aim of this study was to discuss the relationship between Ki-67 values and the degree to which chordoma invade the clivus, and to certify that the prognosis of chordoma is worse when it invades the middle and lower clivus...
Related ArticlesBreakage and Retrieval of Aspiration Catheter Coil with a Stent Retriever During Mechanical Thrombectomy-A Case Report. World Neurosurg. 2019 Jun 29;: Authors: Otsuka R, Ikeda H, Tsujimoto Y, Kawauchi T, Torikoshi S, Sano N, Hayase M, Toda H Abstract BACKGROUND: Some mechanical thrombectomy techniques for acute ischemic stroke utilize a combination of an aspiration catheter and stent retriever. We experienced a rare case of aspiration...
Related ArticlesAppropriate flow reduction for unilateral ruptured vertebral artery dissection by proximal clipping to prevent rebleeding and medullary infarction. World Neurosurg. 2019 Jun 29;: Authors: Motoyama Y, Takamura Y, Park HS, Miyasaka T, Wada T, Yamada S, Saito K, Nakagawa I, Park YS, Sugie K, Nakase H Abstract BACKGROUND: Medullary infarction (MI) occasionally occurs after treatment of ruptured vertebral artery dissection (VAD). The aim of...
Related ArticlesThe Extradural Minipterional Approach: "Think Small, Play Wider". World Neurosurg. 2019 May;125:534-535 Authors: Martinez-Perez R, Mura JM PMID: 31262431 [PubMed - in process]
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The prevalence of eustachian tube dysfunction symptoms in temporomandibular joint disorder patients.
Related ArticlesThe prevalence of eustachian tube dysfunction symptoms in temporomandibular joint disorder patients. Laryngoscope. 2019 Jul 02;: Authors: Newman AC, Omrani K, Higgins TS, Ting JY, Walgama ES, Wu AW Abstract OBJECTIVES/HYPOTHESIS: Ear fullness and pressure is a common complaint seen in otolaryngology clinics and frequently is attributed to eustachian tube dysfunction (ETD). In addition to traditional tympanometry and physical examination,...
Related ArticlesImpact of Respiratory Compromise in Inpatient Interventional Radiology Procedures with Moderate Sedation in the United States. Radiology. 2019 Jul 02;:182455 Authors: Urman RD, Moucharite M, Flynn C, Nuryyeva E, Ray CE Abstract Background Despite increased use of moderate sedation in interventional radiology (IR), patient reactions to moderate sedation are difficult to predict. The rate, risk factors, and burden of respiratory compromise...
Related ArticlesFertility treatments and the risk of pediatric obstructive sleep apnea in the offspring-Results from a population-based cohort study. Pediatr Pulmonol. 2019 Jul 01;: Authors: Imterat M, Wainstock T, Sheiner E, Landau D, Walfisch A, Harlev A Abstract OBJECTIVE: While the impact of fertility treatments on the perinatal outcome is well established, the long-term effects on offspring are yet to be determined. The current study aimed to investigate...
Related ArticlesCorrelation of sleep microstructure with daytime sleepiness and cognitive function in young and middle-aged adults with obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2019 Jul 01;: Authors: Li N, Wang J, Wang D, Wang Q, Han F, Jyothi K, Chen R Abstract PURPOSE: To compare microstructural features of sleep in young and middle-aged adults with differing severities of obstructive sleep apnea syndrome (OSAS), and to investigate...
Related ArticlesAssessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2019 Jul 01;: Authors: Savaş Ö, Süslü AE, Lay I, Özer S Abstract PURPOSE: The relationship of plasma malondialdehyde (MDA) with major parameters of PSG was investigated to find out if there was a correlation between these variables. METHODS: Polysomnograms were...
Related ArticlesThe effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study. BMC Pulm Med. 2019 Jul 01;19(1):118 Authors: Tickoo M, Ruthazer R, Bardia A, Doron S, Andujar-Vazquez GM, Gardiner BJ, Snydman DR, Kurz SG Abstract BACKGROUND: Despite well-defined criteria for use of antibiotics in patients presenting with...
Related Articles[Clinical application of portable monitoring device in the diagnosis of obstructive sleep apnea hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):477-480 Authors: Lu M, Fang F, Wei YX PMID: 31262117 [PubMed - in process]
Related Articles[The role of body fat rate in the evaluation of obstructive sleep apnea]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):427-431 Authors: Li T, Yao ZM, Wang L, Tao LY, Yu XN, Sun SL, Hu WN, Du YL, Yan Y Abstract Objective: To investigate the role of body fat ratio in the evaluation of obstructive sleep apnea(OSA). Methods: A retrospective analysis was made on 174 cases (between November, 2017 and April, 2018 showed that)...
Related Articles[The effect of genioglossus activity to velopharyngeal surgery in patient with obstructive sleep apnea hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):421-426 Authors: Zhao D, Li YR, Qu Y, Xian JF, Cao X, Zhang JB, Ye JY Abstract Objective: To investigate the effect of genioglossus (GG) activation at sleep onset on the outcome of velopharyngeal surgery in obstructive sleep apnea hypopnea syndrome (OSAHS)...
Related Articles[Effect of oral appliance treatment on age-related changes of sleep respiratory function in patients with obstructive sleep apnea hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):410-415 Authors: Gong X, Yu M, Li WR, Gao XM Abstract Objective: The severity of obstructive sleep apnea hypopnea syndrome (OSAHS) has a tendency to increase with age. The purpose of this study was to explore whether oral appliance...
Related Articles[Polysomnographic comparation between dexmedetomidine-induced sleep and natural sleep]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):405-409 Authors: Xu JK, Ye JY, Cao X, Zhang YH, Yuan XM, Zhao CM Abstract Objective: To compare the parameters of polysomnography (PSG) in sleep structure and respiratory events between dexmedetomidine-induced sleep and natural sleep. Methods: From April 2016 to September 2018, a total...
Related Articles[Appropriate understanding of obstructive sleep apnea and sleep disordered breathing]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):401-404 Authors: Ye JY PMID: 31262102 [PubMed - in process]
Related ArticlesPredicting sleep-related oxygen desaturation. Minerva Anestesiol. 2017 05;83(5):431-433 Authors: Calero K, Rumbak M PMID: 28326755 [PubMed - indexed for MEDLINE]
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