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Πέμπτη 8 Σεπτεμβρίου 2022

SARS‐CoV‐2 IgG “heritage” in newborn: a credit of maternal natural infection

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Abstract

Introduction

Description of transplacental passage of specific SARS-CoV-2 IgG from mothers who contracted natural infection to their newborns.

Methods

Retrospective cohort analysis including pregnant women diagnosed with SARS-CoV-2and their newborns both tested for SARS-CoV2 specific IgG and IgM with antibody titration at delivery. NPS were taken from both mothers and neonates, and tested for SARS-CoV-2 using PCR.

Results

IgM and IgG were analyzed in maternal and neonatal serum of 143 mother-infant dyads. 86% of women with a positive SARS-CoV-2 PCR > 14 days before delivery developed specific IgG and 84% of their infants showed transplacental passage of IgG.

Conclusions

Pregnant women infected with SARS-CoV-2 achieve antibody seroconversion following the kinetics described in the general population, and transplacental transfer of IgG specific antibodies occurs. No conclusion can be drawn on passive immunity efficacy or duration.

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Delayed tracheal rupture following transoral endoscopic thyroidectomy vestibular approach: Case report and review of the literature

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Abstract

Background

Although the transoral endoscopic thyroidectomy vestibular approach (TOETVA) has been proven to be a safe procedure for select patients, as it is a novel approach, all associated complications require adequate attention.

Methods

We presented a 49-year old woman who underwent TOETVA developed delayed tracheal rupture 1 week after surgery. An extensive search of literature was carried out using PubMed, Embase, and Web of Science for studies reporting tracheal injury following endoscopic thyroidectomy.

Results

Thirteen cases of endoscopic thyroidectomy were analyzed, including eight cases of TOETVA. Tracheal injury occurred during various procedures, including accidental dissection, surgical needle puncture, Hegar dilation and trocar placement, and thermal injury by the energy device.

Conclusions

Tracheal injury following TOETVA is an underreported complication that can be induced by various factors. Thermal injury to the trachea is more likely to cause a delayed rupture. Careful blunt dissection and standardized use of energy devices are suggested.

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Correlation between radiologic and pathologic extranodal extension in HPV‐associated oropharyngeal cancer: Systematic review

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Abstract

Pretreatment determination of extranodal extension (ENE) has significant clinical implications in human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). Unfortunately there is no gold-standard imaging modality for radiological assessment of ENE in HPV+ OPSCC, leading to subjective assessments and complex decision making concerning ENE. A systematic review of diagnostic test accuracy was therefore undertaken, with five databases systemically searched to evaluate the diagnostic performance of an imaging modality for detection of ENE in HPV+ OPSCC. A meta-analysis was conducted on four CT studies using a random-effects model. While a narrative synthesis was provided for the studies using PET/CT and "CT and MRI." Out of 1772 hits, six studies were included in the review. Meta-analysis on four CT studies showed CT had an overall sensitivity of 77% and specificity of 60%. PET/CT had a sensitivity of 37.5% and specificity of 97%. "CT and MRI" had a se nsitivity of 62% and specificity of 78%. Further diagnostic studies involving CT, PET/CT and MRI are ultimately required.

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Fully digital versus conventional workflow for horizontal ridge augmentation with intraoral block bone: A randomized controlled clinical trial

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Abstract

Objectives

To compare the outcome and efficiency of the computer-aided intraoral block bone grafting procedure with those of the conventional technique for the augmentation of horizontal ridge defects.

Materials and Methods

A total of 28 patients with single missing tooth in esthetic zone with class IV horizontal alveolar bone defect in need of dental implant restoration were recruited. Computer-aided design of the implant restoration and intraoral block bone grafting was performed for all the participants. The patients were randomly and equally divided into guide and control groups. A fully guided bone harvesting, trimming, and grafting surgery was executed in the guide group. The control group patients underwent surgery without any guide. After 6 months, all the patients underwent implant placement. The primary outcomes were the root mean square estimate (RMSE) values between the outer contours of the actual implanted and planned bone block as well as the RMSE values between the inner surface of the implanted bone block and the original bone surface of the recipient site immediately after surgery. The secondary outcomes were the trimming time of bone block and the surgery-associated complications. The postoperative visual analog scale (VAS) of pain, swelling, and mouth opening difficulty was recorded.

Results

All 28 patients underwent intraoral block bone grafting, followed by the placement of implant after 191.8 ± 19.69 days. The RMSE values between the outer contours of the implanted and planned bone blocks were significantly lower in the guide group (0.37 ± 0.16 mm) as compared to those in the control group (0.72 ± 0.29 mm) (p = 0.0007). The RMSE values between the inner contours of the graft block and original bone at the recipient site were lower in the guide group (0.35 ± 0.15 mm) as compared to those in the control group (0.48 ± 0.17 mm) (p = 0.043). The duration of bone block trimming was shorter in the guide group (401.51 ± 97.60 s) as compared to the control group (602.36 ± 160.57 s) (p = 0.0005). In the control group, two patients received secondary bone grafting, one patient experienced bleeding of donor site and temporary hypoesthesia of the lower lip and chin skin, and one patient developed temporary sensitivity of the adjacent tooth.

Conclusions

As compared to the conventional procedure, the fully digital workflow in the present study seemed to be a more accuracy and effective protocol for horizontal ridge augmentation with intraoral block bone. Trial registration: Chictr.org.cn (ChiCTR2000036390).

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Perioperative Outcomes in Fibula, Osteocutaneous Radial Forearm, and Scapula Free Flaps

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This cohort study assesses whether fibula free flaps, osteocuta neous radial forearm free flaps, and scapula free flaps are associated with differences in perioperative outcomes in patients undergoing osseous head and neck reconstruction.
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Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for COVID-19–Related Olfactory Dysfunction

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This randomized clinical trial evaluates the efficacy and safety of theophylline added to saline nasal irrigation compared with placebo for COVID-19–related olfactory dysfunction.
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Well-Differentiated Hypopharyngeal Liposarcoma–Associated Airway Obstruction

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This case report describes a man in his 70s who presented with a bilobed, cylindrical mucosal mass that had been expelled from his mouth after an episode of nausea and violent vomiting.
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Progressive Hoarseness and Laryngeal Obstruction in an Elderly Man

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An otherwise healthy man in his 60s with no prior history of smoking, head and neck surgeries, or radiation exposure presented with a 1-year medical history of progressively worsening hoarseness and dyspnea. What is your diagnosis?
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Exophytic Laryngeal Mass

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A 29-year-old woman presented with postnasal drip, pharyn gitis, odynophagia, cervicalgia, cervical lymphadenopathy, and right-sided otalgia that had persisted for more than a week; what is your diagnosis?
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Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection

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This retrospective analysis of patients who underwent thy roid surgery at 16 centers in 4 countries examines modes of nodule detection and differences by geographic area.
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Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Pediatric Patients

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This case-control study investigates whether increased ris k of sensorineural hearing loss is associated with macrolide use in a national study population of children, adolescents, and young adults.
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