Publication date: December 2019Source: Current Opinion in Neurobiology, Volume 59Author(s): Javed M Chitaman, Peter Fraser, Jian FengAberrant gene expression underlies drug addiction. Therefore, studying the regulation of gene expression in drug addiction may provide mechanistic insights into this disease, for which there are still only limited treatments. Recently, the three-dimensional (3D) organization of linear DNA in the nucleus has been recognized as having a major influence on gene transcription....
Mark above section as read
Objective: While it is known that connected speech has different features to single-word speech, there are currently few recommendations regarding connected speech transcription. This research therefore aimed to develop a clinically feasible protocol for connected speech transcription. The protocol was then used to assist with description of the connected speech of children with childhood apraxia of speech (CAS), as little is known about their connected speech characteristics. Participants and Methods:...
Background: Differential diagnosis and treatment planning of developmental speech disorders (DSD) remains a major challenge in paediatric speech-language pathology. Different classification systems exist, in which subtypes are differentiated based on their theoretical cause and in which the definitions generally refer to speech production processes. Accordingly, various intervention methods have been developed aiming at different parts of the speech production process. Diagnostic classification in...
Mark above section as read
Abstract Objectives The aim of this study was to examine whether dyslipidemia is associated with periodontitis according to age, sex, smoking, and harmful alcohol use in a representative sample of Korean adults who participated in the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3). Materials and methods We examined 3987 subjects...
Mark above section as read
Publication date: Available online 2 July 2019Source: Behavioural Brain ResearchAuthor(s): Hernán Delgado, Daniella Agrati, Luna Machado, Laura Reyes, Eduardo Savio, Henry Engler, Annabel FerreiraAbstractCocaine exposure disrupts the maternal behavior of lactating rats, yet it is less known whether it alters the affective changes that accompany motherhood. As the long-term action of cocaine on anxiety varies according to the developmental stage of the individuals, this study aimed to compare the...
Publication date: Available online 2 July 2019Source: Behavioural Brain ResearchAuthor(s): Baiba Svalbe, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Solveiga Grinberga, Eduards Sevostjanovs, Osvalds Pugovics, Maija Dambrova, Liga ZvejnieceAbstractThe N-methyl-D-aspartate receptor antagonist, MK-801, is widely used to induce memory and learning impairments in preclinical studies. MK-801 is mainly injected intraperitoneally (i.p.) at doses that result in cognitive impairment and induction of motor...
Publication date: Available online 2 July 2019Source: Behavioural Brain ResearchAuthor(s): Lucy R. Lewis, Abigail Benn, Dominic M. Dwyer, Emma S.J. RobinsonAbstractMajor depressive disorder (MDD) is one of the leading global causes of disability. Symptoms of MDD can vary person to person, and current treatments often fail to alleviate the poor quality of life that patients experience. One of the two, core diagnostic criteria for MDD is the loss of interest in previously pleasurable activities, which...
Mark above section as read
Publication date: Available online 3 July 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): G.A. Rodrigues, A. Ribeiro-Silva, A.C. F. Motta, L.M. Alencar Ramos Innocentini
Publication date: Available online 2 July 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Jihyun Chung, Yong Won Lee
Mark above section as read
Publication date: August 2019Source: Journal of Human Evolution, Volume 133Author(s): Justin Pargeter, Nada Khreisheh, Dietrich StoutAbstractDespite its theoretical importance, the process of stone tool-making skill acquisition remains understudied and poorly understood. The challenges and costs of skill learning constitute an oft-neglected factor in the evaluation of alternative adaptive strategies and a potential source of bias in cultural transmission. Similarly, theory and data indicate that...
Mark above section as read
Publication date: Available online 2 July 2019Source: Clinical NeurophysiologyAuthor(s): Matthew Woolfe, David Prime, Linda Tjoa, Steven O'Keefe, David Rowlands, Sasha DionisioAbstractObjectiveParoxysmal nocturnal movements in epilepsy are a recognised phenomenon, however, the mechanisms that produce them and the effect of the underlying epilepsy still remains elusive. In this study, 10 patients were studied to define the cerebral networks corresponding to these movements and explore how epileptiform...
Publication date: Available online 2 July 2019Source: Clinical NeurophysiologyAuthor(s): Annika P.C. Lutz, André Schulz, Ulrich Voderholzer, Stefan Koch, Zoé van Dyck, Claus Voegele (Vögele)AbstractObjectiveTo assess cardiac interoception in anorexia nervosa (AN) using a multidimensional approach.MethodsWe assessed the physiological dimensions of cardioception, i.e. the peripheral signal itself (heart rate, HR, and heart rate variability, HRV) and its cortical representation (heartbeat evoked potentials,...
Mark above section as read
Publication date: Available online 3 July 2019Source: Gait & PostureAuthor(s): Mark Boocock, Yanto Naudé, Steve Taylor, Jeff Kilby, Grant Mawston
Publication date: Available online 2 July 2019Source: Gait & PostureAuthor(s): Paul Macadam, John Cronin, Jono Neville, Shelley DiewaldAbstractBackgroundWearable inertial sensors enable sprinting to be biomechanically evaluated in a simple and time efficient manner outside of a laboratory setting.Research Question: Are wearable inertial sensors a valid and reliable method for collecting and measuring sprint performance variables compared to referenced systems?MethodsPubMed, SPORTDiscus, and Web...
Publication date: Available online 2 July 2019Source: Gait & PostureAuthor(s): Fernando de Lima, Daniel A. Fernandes, Gilberto Melo, Carlos R. de M. Roesler, Fabrício de S. Neves, Francisco Rosa NetoAbstractBackgroundHip osteoarthritis is one of the major causes of disability worldwide, and although total hip arthroplasty is considered effective in the management of this condition, its effects on postural balance remain unclear.Research QuestionWhat are the effects of total hip arthroplasty for...
Publication date: Available online 2 July 2019Source: Gait & PostureAuthor(s): S. Scharr, F. Salami, D.W.W. Heitzmann, S.I. Wolf
Mark above section as read
Mark above section as read
The middle initial of the author should be “A” instead of “C”. The correct presentation of the author name is Colleen A. Carpenter.
Mark above section as read
Brake oil is an automobile transmission fluid composed of a mixture of toxic alcohols such as ethylene glycols and glycol ethers. Both accidental and intentional ingestion cases have been reported and they can...
Mark above section as read
Related ArticlesATP is stored in lysosomes of greater epithelial ridge supporting cells in newborn rat cochleae. J Cell Biochem. 2019 Jul 02;: Authors: Chen J, Hou S, Yang J Abstract Adenosine triphosphate (ATP), which plays a crucial role in both developing and mature cochleae, is released from greater epithelial ridge (GER) supporting cells of the rat cochlea, but the organelles in which ATP is stored have not yet been identified. Thus, we studied...
Related Articles[Diagnosis and treatment of lymphatic malformations]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun 07;54(6):471-476 Authors: Wang SC, Tai J, Zhang J, Ni X Abstract More than seventy percent of lymphatic malformations (LMs) occur in head and neck region. The management of head and neck LMs is challenging,especially for diffuse and infiltrative cases.It can cause deformity and death in severe patients. Surgical resection is the...
Related ArticlesControlled Drug Delivery Systems for Oral Cancer Treatment-Current Status and Future Perspectives. Pharmaceutics. 2019 Jun 30;11(7): Authors: Ketabat F, Pundir M, Mohabatpour F, Lobanova L, Koutsopoulos S, Hadjiiski L, Chen X, Papagerakis P, Papagerakis S Abstract Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men...
Related ArticlesC1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer. Oncogene. 2018 10;37(43):5780-5793 Authors: Lin MC, Chien PH, Wu HY, Chen ST, Juan HF, Lou PJ, Huang MC Abstract Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies. However, its role in head and neck squamous cell carcinoma (HNSCC) remains...
Mark above section as read
Purpose of review The purpose of this article is to provide an update on the advances made through recent clinical trials regarding the treatment of the signs and symptoms of allergic conjunctivitis and its associated conditions. Recent findings Recent studies have demonstrated significant advancement in the various forms of immunotherapy treatments. Nutritional interventions such as probiotics have surfaced as a viable complementary treatment option. Novel delivery methods such as contact...
Mark above section as read
It is known that small airway disease is present across all asthma severities; however, its prevalence and clinical characteristics in cough variant asthma (CVA) have not been fully illuminated.
Mark above section as read
Gemcitabine is widely utilized in the treatment of pancreatic, ovarian, and non small cell lung cancers. Gemcitabine is associated with a wide spectrum of lung toxicities, ranging from dyspnea 25% of patients to severe pulmonary toxicity in up to 5% of patients. There is a dearth of information specific to pulmonary toxicity in the setting of gemcitabine combination chemotherapy. Given the potential severity, it is important to identify it early by excluding more common etiologies. We share two case...
Mark above section as read
Publication date: August 2019Source: Neoplasia, Volume 21, Issue 8Author(s): Wen-Cheng Chung, Yunyun Zhou, Azeddine Atfi, Keli XuAbstractActivating mutations and amplification of Kras and, more frequently, signatures for Kras activation are noted in stomach cancer. Expression of mutant KrasG12D in the mouse gastric mucosa has been shown to induce hyperplasia and metaplasia. However, the mechanisms by which Kras activation leads to gastric metaplasia are not fully understood. Here we report that KrasLSL-G12D/+;Pdx1-cre,...
Publication date: August 2019Source: Neoplasia, Volume 21, Issue 8Author(s): Jae-Seung Chung, Yugang Wang, James Henderson, Udit Singhal, Yuanyuan Qiao, Alexander B. Zaslavsky, Daniel H. Hovelson, Daniel E. Spratt, Zachery Reichert, Ganesh S. Palapattu, Russell S. Taichman, Scott A. Tomlins, Todd M. MorganAbstractWhile circulating tumor cell (CTC)–based detection of AR-V7 has been demonstrated to predict patient response to second-generation androgen receptor therapies, the rarity of AR-V7 expression...
Publication date: August 2019Source: Neoplasia, Volume 21, Issue 8Author(s): Hidetsugu Kawai, Hiromichi Matsushita, Rikio Suzuki, Yuka Kitamura, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi AndoAbstractHematological malignancies harboring various ABL1 fusions are expected to be sensitive to tyrosine kinase inhibitors (TKIs), similar to those with BCR-ABL1. However, SEPT9-ABL1 exhibits TKI resistance both in vitro and in vivo. SEPT9-ABL1 has the same ABL1 region as seen in BCR-ABL1 but no point mutation...
Mark above section as read
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00494G, PaperPADMANABHAN EANGOOR, Jennifer Knaack, Amruta Sanjay Indapurkar, Mani Deepika VakkalankaParalytic shellfish poisoning is a lethal syndrome that can develop in humans who consume shellfish contaminated with paralytic shellfish toxins. These toxins have a short half-life in the human body,...The content of this RSS Feed (c) The Royal Society of Chemistry
2h
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00773C, PaperYi Liu, Bin Feng, XiaoZheng Cao, Gao Tang, Honglu Liu, Fang Chen, MeiHui Liu, Qian Chen, Kai Yuan, YongHong Gu, XuePing Feng, Wenbin Zengγ-Glutamyl transpeptidase (GGT) was reported as a biomarker of Hepatocellular carcinoma (HCC), and its imaging is of great benefit for the early detection in precise medicine as well as intraoperative...The content of this RSS Feed (c) The Royal Society of Chemistry
2h
Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN00981G, PaperYao Xie, Guiqin Ye, Suping Peng, Shiyuan Jiang, Yang Wang, Xiaoya HuThiol functionalized water stable zirconium MOFs were synthesized and used for copper adsorption with enhanced adsorption capacity and stability.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
2h
Subcutaneous and transcutaneous monitoring of murine hindlimb ischemia by in vivo Raman spectroscopy
Analyst, 2019, Advance ArticleDOI: 10.1039/C8AN02449A, PaperRida Al-Rifai, Claire Tournois, Samar Kheirallah, Nicole Bouland, Gaël Poitevin, Philippe Nguyen, Abdelilah BeljebbarWe have investigated the development of murine hindlimb ischemia from day 1 to day 55 after femoral artery ligation (FAL) using blood flow analysis, functional tests, histopathological staining, and in vivo Raman spectroscopy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content...
2h
Mark above section as read
Mark above section as read
Abstract Female genitalia have been largely neglected in studies of genital evolution, perhaps due to the long standing belief that they are relatively invariable and therefore taxonomically and evolutionarily uninformative in comparison to male genitalia. Contemporary studies of genital evolution have begun to dispute this view, and to demonstrate that female genitalia can be highly diverse and covary with the genitalia of males. Here we examine evidence for three mechanisms of genital evolution...
Mark above section as read
Paediatric critical care practitioners often make use of pressure support (PS) to overcome the perceived imposed work of breathing (WOBimp) during an extubation readiness test (ERT). However, no paediatric dat...
In the past, the only treatment of acute exacerbations of obstructive diseases with hypercapnic respiratory failure refractory to medical treatment was invasive mechanical ventilation (IMV). Considerable techn...
Mark above section as read
Abstract This commentary discusses the need to move on from the adoption of cut‐off points for the definition of the presence/absence of bruxism and justifies the need to embrace an evaluation based on the continuum of jaw motor behaviours. Currently, the number of events per hour, as identified by polysomnography (PSG), is used to define the presence of sleep bruxism (SB). Whilst PSG still remains the indispensable equipment to study the neurophysiological correlates of SB, the scoring criteria...
Mark above section as read
Abstract Sex chromosome trisomies (SCT) are among the most common chromosomal duplications in humans. Due to recent technological advances in non‐invasive screening, SCT can already be detected during pregnancy. This calls for more knowledge about the development of (young) children with SCT. This review focused on neurocognitive functioning of children with SCT between 0‐18 years, on domains of global intellectual functioning, language, executive functioning, and social cognition, in...
Mark above section as read
Abstract Introduction Although pre‐Hispanic hunter‐gatherer and horticulturalist (known as Guaraní) societies from the lower Paraná River Delta (Argentina) presented differences in diet, pottery decoration, mortuary practices, and places of origin, differences in skeletal morphology between such groups have never been systematically explored. This work focuses on variations in humeral and femoral external linear measurements and derived structural properties of adult individuals from both societies...
Abstract Objectives Wild Sapajus libidinosus exploit underground storage organs (USOs) that require extraction and extensive processing before consumption. Since capuchin monkeys are small‐sized extractive foragers that cannot perform forceful precision grips, we expected that: (a) they would use other body parts together with their hands, (b) older (and larger) capuchins would be more efficient than younger (and smaller) ones, and (c) capuchins would invest greater effort/time to exploit USOs...
Mark above section as read
Abstract Purpose of Review Back pain is a growing problem worldwide, incurring enormous economic costs and disability. Current treatment modalities often provide adequate relief but fail to address underlying conditions. Regenerative cellular modalities aim to restore anatomical function in degenerative conditions which may cause low back pain. Platelet-rich plasma (PRP) consists of an increased concentration of autologous platelets...
Mark above section as read
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.