Allergy,

Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D2 and cysteinyl leukotrienes in allergic rhinitis

Abstract Background Group 2 innate lymphoid cells (ILC2s) play important roles in allergic inflammation. However, their roles in the pathophysiology of allergic rhinitis (AR) are poorly understood. Objective Prevalence of ILC2s in the inferior nasal turbinate (INT) tissues and the activating mechanisms of ILC2s were examined in patients with house dust mites (HDM)‐induced AR. Methods 18 patients with HDM‐induced AR and 13 control subjects were recruited. Fresh INT tissues and peripheral...

Allergy

4h

Oral immunotherapy with antigenicity‐modified casein induces desensitization in cow's milk allergy

Allergy

4h

Different Endotypes and Phenotypes drive the Heterogeneity in Severe Asthma

Abstract The identification of sputum eosinophilia indicating corticosteroid responsiveness in subjects with severe asthma heralded the beginning of phenotyping asthmatic subjects based on airways inflammation. Since then, the heterogeneity of severe asthma has been explored and the importance of immunobiology has come sharply into focus with the identification of the key Type 2 cytokine pathways driving eosinophilic inflammation. The development of molecules targeting these Type 2 pathways has...

Allergy

4h

Toll‐like receptor 2 stimulation augments esophageal barrier integrity

Abstract Background Germline‐encoded innate immune pattern recognition receptors (PRR) are expressed at epithelial surfaces and modulate epithelial defenses. Evidence suggests that stimulation of the Toll‐like receptor (TLR) family of PRR may regulate epithelial barrier integrity by upregulating tight junction (TJ) complex protein expression, but it is not known if this mechanism is utilized in esophageal epithelial cells. TJ complex proteins maintain intact barrier function, and are dysregulated...

Allergy

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 Clinical & Experimental Allergy,

Short‐term high fat diet feeding protects from the development of experimental allergic asthma in mice

Abstract Background A close asssociation between obesity and asthma has been described. The nature of this association remains elusive, especially with respect to allergic asthma. Controversial findings exist regarding the impact short‐term high fat diet (HFD) feeding on the development of allergic asthma. Objective To delineate the impact of short‐term HFD feeding on the development of experimental allergic asthma. Methods Female C57BL/6JRJ mice were fed with a short‐term HFD or...

Clinical & Experimental Allergy

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 ScienceDirect Publication: Annals of Allergy, Asthma & Immunology

Clinically Relevant Contact Allergens in the Modern Era

Publication date: Available online 2 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Emily C. Milam, David E. Cohen

ScienceDirect Publication: Annals of Allergy, Asthma & Immunology

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Asthma and viral infections: an intricate relationship

Publication date: Available online 2 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Irene Mikhail, Mitchell H. Grayson

ScienceDirect Publication: Annals of Allergy, Asthma & Immunology

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Systemic Reactions to Subcutaneous Immunotherapy (SCIT): Effects of Dosing and Aeroallergen Content

Publication date: Available online 2 July 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): S Shahzad Mustafa, Theresa Bingemann, Holly Blue, Kelly Conn, Todd Hanley, Allison Ramsey

ScienceDirect Publication: Annals of Allergy, Asthma & Immunology

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