Photodermatology, Photoimmunology &Photomedicine, Volume 0, Issue ja, -Not available-.
Δευτέρα 24 Σεπτεμβρίου 2018
Comparison of UV protection properties of cotton fabrics treated with aqueous and Methanolic extracts of Solanum Nigrum and Amaranthus Viridis Plants
A Systematic Review of Evidence-Based Treatments for Prurigo Nodularis
This review provides evidence supporting some efficacy of topical agents and phototherapy in treatment of prurigo nodularis, while highlighting emerging therapeutic potential from modulation of neurokinin-1 receptor, interleukin-31 receptor, and κ-opioid receptor signaling. Higher-powered studies for prurigo nodularis treatments are needed.
AIDS‐associated disseminated talaromycosis (penicilliosis) marneffei
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Histological intralesional heterogeneity of actinic keratoses relates to field cancerization
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
The efficacy of ablation‐based combination therapy for vitiligo: A systematic review and meta‐analysis
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Female type of adult acne: Physiological and psychological considerations and management
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Multiple livid‐erythematous macules and plaques with slight scaling in a young man
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Decoupling between sulfate reduction and the anaerobic oxidation of methane in the shallow methane seep of the Black sea.
Abstract
Methane seepages are widespread in the Black Sea. However, microbiological research has been carried out only at the continental shelf seeps. The present work dealt with coastal gas seepages of the Kalamit Bay (Black Sea). High-throughput 16S rRNA gene sequencing and radiotracer analysis (14С and 35S) were used to determine the composition of the microbial community and the rates of microbial sulfate reduction and methane oxidation. The phylum Proteobacteria, represented mainly by sulfate reducers of the class Deltaproteobacteria, was the predominant in sequence dataset. Bacteroidetes and Planctomycetes were other numerous phyla. Among archaea, the phylum Woesearchaeota and Marine Benthic Group B were predominant in the upper horizons. Relative abundance of Euryarchaeota of the families Methanomicrobiacea and Methanosarcinaceae (including ANME-3 archaea) increased in deeper sediment layers. Sulfate reduction rate (up to 2.9 mmol/L×day) was considerably higher than the rate of anaerobic methane oxidation (up to 43.4 μmol/L×day), which indicated insignificant contribution of anaerobic methane oxidation to the total sulfide production.Improving control in microbial cell factories: from single cell to large-scale bioproduction
Abstract
Bioprocess deviations are likely to occur at different operating scales, leading in most of the case to substrate deviation from main metabolic routes and impact product synthesis. Correlating qS and qP is of outmost importance for bioprocess observability and control and can be modeled actually by advanced metabolic flux models. However, if most of these models are able to make prediction about metabolic switches, they still do not incorporate deviation due to biological noise, i.e. phenotypic and genotypic heterogeneity. These limitations impair observability and thus the use of fundamental knowledge about biological network for practical application, i.e. metabolic engineering or bioprocess scale-up.A novel sucrose based expression system for heterologous proteins expression in thermotolerant methylotrophic yeast Ogataea thermomethanolica
Abstract
The thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC656 is a potential host for heterologous protein expression. In this study, a novel expression system was developed for O. thermomethanolica based on the maltase (mal) gene promoter from this organism. The OtMal promoter function was tested for expression of fungal enzymes as reporter genes. Measurement of xylanase reporter enzyme activity showed that the OtMal promoter was repressed during growth on glucose and was activated by sucrose. When sucrose was used as a carbon source, the OtMal promoter was approximately twice as strong as the constitutive OtGAP promoter. Comparison of the OtMal promoter with the methanol-inducible OtAOX promoter showed that OtMal promoter drove 1.2 and 1.7 fold higher expression of xylanase and phytase reporter, respectively than OtAOX promoter under inducing conditions at 24 hr. Our results indicated that this novel expression system could be useful for the production of heterologous proteins from sucrose in yeast O. thermomethanolica.The Escherichia coli bcsB gene is a conditional essential gene in the context of functional cellulose synthesis.
Abstract
The understanding of why a gene is essential for a bacterium has implications in different research areas, such as bacterial evolution, synthetic biology, and biotechnology, making the identification of essential genes a very active research field. Bacterial essential genes have been defined, among other criteria, by the inability to obtain viable mutants in such genes. In the case of Escherichia coli this approach led to the construction of the Keio collection of single-gene knockout mutants that contains deletions of all the open reading frames present in the genome with the exception of 303 genes that were found to be essential for the growth of this bacterium. One of the genes that was identified as essential is bcsB, which is involved in synthesis of extracellular cellulose. However, the reason for the essential nature of BcsB for E. coli viability has not been determined. In this work we show that bcsB is essential only in strains that have a functional capacity to synthesize cellulose, presumably due to the activity of BcsB in the translocation of this polymer across the periplasm. Thus we propose that bcsB is a conditionally essential gene in E. coli.Systematic review of mobile phone-based teledermatology
Abstract
Teledermatology is an expanding field within dermatology that has grown and become more clinically accepted by both patients and doctors. With approximately 260 million mobile phone users in the US and 4–6 billion worldwide with access to mobile phones, teledermatology serves as a potentially useful tool for diagnosis and management (Samkange-Zeeb and Blettner in Emerg Health Threats J, https://ift.tt/2QRnU0t, 2009). In this review, we provide a detailed overview of mobile phone technology and the accumulating evidence for its incorporation into dermatology. Key questions addressed include accuracy and concordance between mobile teledermatology and face-to-face dermatology for the diagnosis of skin conditions. Similarly, accuracy and concordance were compared for the management of skin conditions. To track the development of mobile phone technology, we also assessed how data were captured, stored, and displayed in teledermatology studies.
A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta
Journal of Medical Primatology, EarlyView.
Absorbable vs non absorbable sutures for wound closure. Systematic review of systematic reviews
Publication date: Available online 24 September 2018
Source: Wound Medicine
Author(s): Sharaf Sheik-Ali, Wilfried Guets
Abstract
Objective
To provide an overview of evidence on Absorbable and non-absorbable sutures (AS & NAS) for the closure of surgical incisions
Methods
Medline, Embase and Cochrane library were searched for systematic reviews including randomised control trials (RCTs) on AS and NAS. Those that matched the inclusion criterion were analysed for data on surgical site infections, post operative complications and risk of wound dehiscence.
Results
The systematic review of reviews yielded data on 5781 patients in 25 RCTs. There was no significant difference (p < 0.05) noted in surgical site infections, post operative complications or risk of wound dehiscence post use of NAS or AS sutures.
Conclusion
This study demonstrates that absorbable sutures are not superior to non absorbable sutures in the three areas examined: surgical site infections, post operative complications and risk of wound dehiscence. However, there was significant heterogeneity between included RCTs in the systematic reviews. Further RCTs are needed to evaluate the differences between absorbable and non absorbable sutures that are reflected in size of wounds and location.
Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy
Dermatologic Therapy, EarlyView.
Science Through Narrative: Engaging Broad Audiences – An Introduction to the Symposium
Synopsis
Due to the politicization of science and the proliferation of misinformation about science and its significance, it has never been more crucial for scientists to clearly articulate the importance of science to the public. Despite this, many scientists often (1) do not acknowledge the importance of broader scientific communication; (2) are not familiar with tools or resources that can improve their communication of science, both amongst colleagues and to the general public; and (3) do not receive such training through their degree or job training programs. In this symposium, scientists who work across multiple disciplines in entertainment, communication, and narrative are brought together with entertainment and communication industry professionals practiced in interpreting and presenting complex data in thoughtful and cogent ways. Together, they offer lessons learned and provide engagement strategies for integrative and comparative biology and for science in general.The World of Melanoma: Epidemiologic, Genetic, and Anatomic Differences of Melanoma Across the Globe
Abstract
Purpose of Review
As cancer remains an increasing problem in industrial countries, the incidence of melanoma has risen rapidly in many populations during the last decades and still continues to rise. Current strategies aiming to control the disease have largely focused on improving the understanding of the interplay of causal factors for this cancer.
Recent Findings
Cutaneous melanoma shows clear differences in incidence, mortality, genomic profile, and anatomic presentation, depending on the country of residence, ethnicity, and socioeconomic status. Known risk factors are multiple atypical nevi, positive family and/or personal history, immune suppressive diseases or treatments, and fair skin phenotype. Besides new adjuvant therapeutic options, changed attitude toward leisure and sun exposure, primary prevention, and early detection are major contributors to disease control.
Summary
Melanoma is a disease of multifactorial causality and heterogeneous presentation. Its subtypes differ in origin, anatomical site, role of UV radiation, and mutational profile. Better understanding of these differences may improve prevention strategies and therapeutic developments.
Chronic hand eczema in Germany: 5‐year follow‐up data from the CARPE registry
Contact Dermatitis, EarlyView.
Occupational allergic contact dermatitis caused by cobalt in machine oil
Contact Dermatitis, EarlyView.
The use of a custom-made virtual template for corrective surgeries of asymmetric patients: proof of principle and a multi-center end-user survey
Abstract
Aim
To evaluate the utility of an individualized template for corrective surgeries for patients suffering from mandibular asymmetry.
Materials and method
Twenty patients with history of favorable clinical outcome of the correction of their mandibular asymmetry were chosen. CBCTs were taken before and 6 weeks postoperative using NewTom 3G. Each volume is mirrored and registered on the cranial base. Surface models for the mandible and its registered mirror were used to compute a template using deformable fluid registration. Surgery was simulated based of the resulting template. A multi-center survey using "Qualtrics" was conducted to gain clinical feedback of 20 surgeons/orthodontists comparing treatment outcomes.
Results
Twenty-three clinicians participated. More clinicians rated simulated outcome to be "Good," whereas the actual surgical outcomes were rated as "fair" and "poor." This was true for regional appraisal for the chin, Rami, and body of the mandible as well as the overall assessment of the outcome of surgeries. The gains of computer-assisted simulation tend to be greater for difficult cases especially for the body of the mandible, then the chin, and then the Ramus correction.
Conclusions
This approach has the potential to optimize and increase the predictability of the outcome of craniofacial corrective surgeries for asymmetric patients.
Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study
Clinical and Experimental Dermatology, EarlyView.
Topical dapsone gel is a new treatment option for acne agminata
Clinical and Experimental Dermatology, EarlyView.
Characterization of eomesodermin and T‐bet expression by allostimulated CD8+ T cells of healthy volunteers and kidney transplant patients in relation to graft outcome
Clinical &Experimental Immunology, EarlyView.
Differences of Mohs micrographic surgery in basal cell carcinoma versus squamous cell carcinoma
International Journal of Dermatology, EarlyView.
Filaggrin gene polymorphisms in Iranian ichthyosis vulgaris and atopic dermatitis patients
International Journal of Dermatology, EarlyView.
Evaluation of structural damage and pH of nail plates of hands after applying different methods of decorating
International Journal of Dermatology, EarlyView.
Letter to the Editor regarding “Ertapenem – a potent treatment for clinical and quality of life improvement in patients with hidradenitis suppurativa”
International Journal of Dermatology, EarlyView.
Transient symptomatic zinc deficiency in a breast‐fed African infant: case report and literature review
International Journal of Dermatology, EarlyView.
Allogeneic skin donors from a tissue bank in Southern Brazil: clinical and epidemiological profiles and microbial colonization of skin
International Journal of Dermatology, EarlyView.
Diagnostic values of KOH examination, histological examination, and culture for onychomycosis: a latent class analysis
International Journal of Dermatology, EarlyView.
An extremely rare association of multiple familial trichoepitheliomas and hereditary multiple osteochondromas
International Journal of Dermatology, EarlyView.
Ankle‐brachial index in psoriasis: a population‐based study
International Journal of Dermatology, EarlyView.
Review of safety and efficacy of approved systemic psoriasis therapies
International Journal of Dermatology, EarlyView.
Amelanotic melanoma arising in an area of SLURP‐1 mutated Mal de Meleda
International Journal of Dermatology, EarlyView.
Measurement properties of three assessments of burden used in atopic dermatitis in adults
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Niedrig dosierte prophylaktische orale Therapie mit Isotretinoin über 18 Jahre bei einer Patientin mit Epidermodysplasia verruciformis und zahlreichen Plattenepithelkarzinomen
Zusammenfassung
Epidermodysplasia verruciformis (auch Lewandowsky-Lutz-Dysplasie) ist eine extrem seltene autosomal-rezessive Genodermatose, bei der eine ungewöhnlich hohe Empfindlichkeit der Haut gegenüber humanen Papillomviren vorliegt. Die Erkrankung ist mit einem hohen Risiko für die Entwicklung von nichtmelanozytären Hauttumoren verbunden. Eine Behandlung mittels keratolytischen Retinoiden gilt derzeit als die effektivste Therapie. Retinoide haben ein breites Wirkungsspektrum und hemmen das Wachstum von Plattenepithelkarzinomen und anderen bösartigen Tumoren. Wir berichten über eine 81-jährige Patientin, die aufgrund einer Epidermodysplasia verruciformis (Nachweis von HPV 9 und HPV 57) mit der raschen Entwicklung zahlreicher kutaner Karzinome seit ca. 18 Jahren eine prophylaktische orale Therapie mit Isotretinoin in einer Dosis von 1,0–0,33 mg/kg Körpergewicht täglich erhält. Im Verlauf zeigte sich eine starke Reduktion der Inzidenz, des Größenwachstums und der Invasionsneigung von weiteren Karzinomen der Haut, sodass wir im vorliegenden Fall einen protektiven Effekt der Retinoidgabe auf die Aktivität der Hautkrebserkrankung postulieren.
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Publication date: Available online 28 September 2017 Source: Actas Dermo-Sifiliográficas Author(s): F.J. Navarro-Triviño
