future oncology,

Fibroblasts in cancer: Defining target structures for therapeutic intervention.

Related ArticlesFibroblasts in cancer: Defining target structures for therapeutic intervention. Biochim Biophys Acta Rev Cancer. 2019 Jun 29;: Authors: Boesch M, Baty F, Rumpold H, Sopper S, Wolf D, Brutsche MH Abstract The functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated...

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Combinatorial strategies of radiotherapy in the management of nasopharyngeal carcinoma.

Related ArticlesCombinatorial strategies of radiotherapy in the management of nasopharyngeal carcinoma. Br J Radiol. 2019 Jul 02;:20190209 Authors: Sun XS, Li XY, Chen QY, Tang LQ, Mai HQ Abstract Nasopharyngeal carcinoma (NPC) is a malignancy with unique clinical biological profiles such as associated Epstein-Barr virus infection and high radiosensitivity. Radiotherapy has long been recognized as the mainstay for the treatment of NPC. However, the further...

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Whole-Exome Sequencing Of Ovarian Cancer Families Uncovers Putative Predisposition Genes.

Related ArticlesWhole-Exome Sequencing Of Ovarian Cancer Families Uncovers Putative Predisposition Genes. Int J Cancer. 2019 Jul 02;: Authors: Zhu Q, Zhang J, Chen Y, Hu Q, Shen H, Huang RY, Liu Q, Kaur J, Long M, Battaglia S, Eng KH, Lele SB, Zsiros E, Villella J, Lugade A, Yao S, Liu S, Moysich K, Odunsi KO Abstract Despite the identification of several ovarian cancer (OC) predisposition genes, a large proportion of familial OC risk remain unexplained....

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Health care utilization and mortality associated with heart failure-related admissions among cancer patients.

Related ArticlesHealth care utilization and mortality associated with heart failure-related admissions among cancer patients. ESC Heart Fail. 2019 Jul 02;: Authors: Guha A, Dey AK, Armanious M, Dodd K, Bonsu J, Jneid H, Abraham W, Fradley MG, Addison D Abstract AIMS: Heart failure (HF) outcomes continue to improve with widespread use of new therapies. Concurrently, cancer survival has dramatically improved. Yet whether cancer patients share similar strategies...

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Implementation and Outcomes of a Molecular Tumor Board at Herbert-Herman Cancer Center, Sparrow Hospital.

Related ArticlesImplementation and Outcomes of a Molecular Tumor Board at Herbert-Herman Cancer Center, Sparrow Hospital. Acta Med Acad. 2019 Apr;48(1):105-115 Authors: Trivedi H, Acharya D, Chamarthy U, Meunier J, Ali-Ahmad H, Hamdan M, Herman J, Srkalovic G Abstract OBJECTIVE: This paper describes our experience and outcomes from 54 cases presented to the (Molecular tumor board) MTB. METHODS: 54 Cases presented between July 2017 and April...

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Genomic-Based Therapy of Gynecologic Malignancies.

Related ArticlesGenomic-Based Therapy of Gynecologic Malignancies. Acta Med Acad. 2019 Apr;48(1):84-89 Authors: Markman M Abstract This paper will review the current status of genomic-based therapy of gynecologic malignancies. The routine "standard-of-care" delivery of targeted therapeutics based on the presence of specific molecular biomarkers in the management of the gynecologic malignancies has been delayed compared to the substantial progress made...

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Genomics in Hematology and Oncology Practice.

Related ArticlesGenomics in Hematology and Oncology Practice. Acta Med Acad. 2019 Apr;48(1):1-5 Authors: Srkalovic G PMID: 31264428 [PubMed - in process]

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Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin.

Related ArticlesMultifunctional Pharmaceutical Effects of the Antibiotic Daptomycin. Biomed Res Int. 2019;2019:8609218 Authors: Ye Y, Xia Z, Zhang D, Sheng Z, Zhang P, Zhu H, Xu N, Liang S Abstract Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare...

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Carcinoembryonic Antigen Levels and Survival in Stage III Colon Cancer: Post hoc Analysis of the MOSAIC and PETACC-8 Trials.

Related ArticlesCarcinoembryonic Antigen Levels and Survival in Stage III Colon Cancer: Post hoc Analysis of the MOSAIC and PETACC-8 Trials. Cancer Epidemiol Biomarkers Prev. 2019 Jul;28(7):1153-1161 Authors: Auclin E, Taieb J, Lepage C, Aparicio T, Faroux R, Mini E, Folprecht G, Salazar R, Benetkiewicz M, Banzi M, Louvet C, Van Laethem JL, Tabernero J, Hickish T, de Gramont A, André T, Vernerey D Abstract BACKGROUND: We explored and validated the association...

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Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells.

Related ArticlesBiological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells. Anticancer Res. 2019 Jul;39(7):3615-3620 Authors: Li Petri G, Cascioferro S, El Hassouni B, Carbone D, Parrino B, Cirrincione G, Peters GJ, Diana P, Giovannetti E Abstract Heterocyclic rings are recognized as key components of many natural, semi-synthetic...

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Aspirin Treatment Effect and Association with PIK3CA Mutation in Breast Cancer: A Biomarker Analysis.

Related ArticlesAspirin Treatment Effect and Association with PIK3CA Mutation in Breast Cancer: A Biomarker Analysis. Clin Breast Cancer. 2019 May 18;: Authors: Zhou Y, Simmons J, Jordan CD, Sonbol MB, Maihle N, Tang SC Abstract BACKGROUND: Studies suggest regular aspirin use decreases breast cancer (BRCA) risk, with high doses exerting an "anti-cancer" effect. Despite reports suggesting aspirin's protective role in BRCA, no findings on aspirin dose...

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Application of Biodegradable and Biocompatible Nanocomposites in Electronics: Current Status and Future Directions.

Related ArticlesApplication of Biodegradable and Biocompatible Nanocomposites in Electronics: Current Status and Future Directions. Nanomaterials (Basel). 2019 Jun 29;9(7): Authors: Liu H, Jian R, Chen H, Tian X, Sun C, Zhu J, Yang Z, Sun J, Wang C Abstract With the continuous increase in the production of electronic devices, large amounts of electronic waste (E-waste) are routinely being discarded into the environment. This causes serious environmental...

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Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial.

Related ArticlesSubcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial. Lancet Psychiatry. 2017 11;4(11):839-849 Authors: Holtzheimer PE, Husain MM, Lisanby SH, Taylor SF, Whitworth LA, McClintock S, Slavin KV, Berman J, McKhann GM, Patil PG, Rittberg BR, Abosch A, Pandurangi AK, Holloway KL, Lam RW, Honey CR, Neimat JS, Henderson JM, DeBattista C, Rothschild AJ, Pilitsis JG, Espinoza RT, Petrides...

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